Results 31 to 40 of about 1,231 (164)

A novel liposomal adjuvant system, CAF01, promotes long-lived Mycobacterium tuberculosis-specific T-cell responses in human

Vaccine, 2014
Here, we report on a first-in-man trial where the tuberculosis (TB) vaccine Ag85B-ESAT-6 (H1) was adjuvanted with escalating doses of a novel liposome adjuvant CAF01. On their own, protein antigens cannot sufficiently induce immune responses in humans, and require the addition of an adjuvant system to ensure appropriate delivery and concomitant immune ...
Simone A Joosten, Søren T Hoff, Morten Ruhwald   +2 more
exaly   +4 more sources

Protection against experimental cryptococcosis elicited by Cationic Adjuvant Formulation 01-adjuvanted subunit vaccines. [PDF]

PLoS Pathogens
The fungal infection, cryptococcosis, is responsible for >100,000 deaths annually. No licensed vaccines are available. We explored the efficacy and immune responses of subunit cryptococcal vaccines adjuvanted with Cationic Adjuvant Formulation 01 (CAF01).
Ruiying Wang, Lorena V N Oliveira, Maureen M Hester, Diana Carlson, Dennis Christensen, Charles A Specht, Stuart M Levitz   +6 more
doaj   +2 more sources

Next-generation Candida albicans vaccine VXV-01 containing recombinant Als3p and Hyr1p antigens for invasive Candida infections [PDF]

Scientific Reports
Candida species, including Candida albicans and Candida auris, represent a growing public health concern due to their increasing prevalence and resistance to antifungal agents. C.
Shakti Singh, Eman G. Youssef, Ashley Barbarino, Haley Hautau, Sunna Nabeela, Teclegiorgis Gebremariam, Sondus Alkhazraji, Gary Ostroff, Dennis Christensen, Terrence Cochrane, Ashraf S. Ibrahim   +10 more
doaj   +2 more sources

Syringe free vaccination with CAF01 Adjuvated Ag85B-ESAT-6 in Bioneedles provides strong and prolonged protection against tuberculosis.

PLoS ONE, 2010
Bioneedles are small hollow sugar based needles administered with a simple compressed air device. In the present study we investigate how incorporation of a subunit vaccine based on TB vaccine hybrid Ag85B-ESAT-6 adjuvated with CAF01 into Bioneedles ...
Dennis Christensen, Thomas Lindenstrøm, Gijsbert van de Wijdeven, Peter Andersen, Else Marie Agger   +4 more
doaj   +3 more sources

Cross-Protective Potential and Protection-Relevant Immune Mechanisms of Whole Inactivated Influenza Virus Vaccines Are Determined by Adjuvants and Route of Immunization [PDF]

Frontiers in Immunology, 2019
Adjuvanted whole inactivated virus (WIV) influenza vaccines show promise as broadly protective influenza vaccine candidates. Using WIV as basis we assessed the relative efficacy of different adjuvants by carrying out a head-to-head comparison of the ...
Yoshita Bhide, Wei Dong, Inta Gribonika, Daniëlle Voshart, Tjarko Meijerhof, Jacqueline de Vries-Idema, Stephen Norley, Kate Guilfoyle, Sarah Skeldon, Othmar G. Engelhardt, Louis Boon, Dennis Christensen, Nils Lycke, Anke Huckriede   +13 more
doaj   +6 more sources

Alternatives to mineral oil adjuvants in vaccines against Aeromonas salmonicida subsp. salmonicida in rainbow trout offer reductions in adverse effects [PDF]

Scientific Reports, 2017
In an effort to reduce the frequency and severity of adverse reactions seen from the use of mineral oil adjuvants in salmonid fish, the effects of two alternative adjuvants were assessed, focusing on the induction of adverse effects as well as protection.
Kasper Rømer Villumsen, Erling Olaf Koppang, Dennis Christensen, Anders Miki Bojesen   +3 more
doaj   +3 more sources

Investigating Prime-Pull Vaccination through a Combination of Parenteral Vaccination and Intranasal Boosting [PDF]

Vaccines, 2019
Formulation of inhalable delivery systems containing tuberculosis (TB) antigens to target the site of infection (lungs) have been considered for the development of subunit vaccines. Inert delivery systems such as poly (lactic-co-glycolic acid) (PLGA) are
Carla B. Roces, Maryam T. Hussain, Signe T. Schmidt, Dennis Christensen, Yvonne Perrie   +4 more
doaj   +3 more sources

H65 fusion protein fails to improve the protection of a rationally attenuated live vaccine candidate against bovine tuberculosis in a mouse model of tuberculosis

International Journal of Mycobacteriology, 2021
Background: The fusion protein H65, composed of Mycobacterium tuberculosis (TB) ESX-secreted antigens, has improved the bacillus Calmette–Guerin-induced immune protection in a mouse model of bovine TB when formulated in the liposomal adjuvant CAF01.
Elizabeth A García, Federico C Blanco, Fabiana Bigi   +2 more
doaj   +1 more source

International consensus statement on allergy and rhinology: Allergic rhinitis – 2023

International Forum of Allergy &Rhinology, Volume 13, Issue 4, Page 293-859, April 2023., 2023
Abstract Background In the 5 years that have passed since the publication of the 2018 International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR‐Allergic Rhinitis 2018), the literature has expanded substantially. The ICAR‐Allergic Rhinitis 2023 update presents 144 individual topics on allergic rhinitis (AR), expanded by over 40
Sarah K. Wise, Cecelia Damask, Lauren T. Roland, Charles Ebert, Joshua M. Levy, Sandra Lin, Amber Luong, Kenneth Rodriguez, Ahmad R. Sedaghat, Elina Toskala, Jennifer Villwock, Baharudin Abdullah, Cezmi Akdis, Jeremiah A. Alt, Ignacio J. Ansotegui, Antoine Azar, Fuad Baroody, Michael S. Benninger, Jonathan Bernstein, Christopher Brook, Raewyn Campbell, Thomas Casale, Mohamad R. Chaaban, Fook Tim Chew, Jeffrey Chambliss, Antonella Cianferoni, Adnan Custovic, Elizabeth Mahoney Davis, John M. DelGaudio, Anne K. Ellis, Carrie Flanagan, Wytske J. Fokkens, Christine Franzese, Matthew Greenhawt, Amarbir Gill, Ashleigh Halderman, Jens M. Hohlfeld, Cristoforo Incorvaia, Stephanie A. Joe, Shyam Joshi, Merin Elizabeth Kuruvilla, Jean Kim, Adam M. Klein, Helene J. Krouse, Edward C. Kuan, David Lang, Desiree Larenas‐Linnemann, Adrienne M. Laury, Matt Lechner, Stella E. Lee, Victoria S. Lee, Patricia Loftus, Sonya Marcus, Haidy Marzouk, Jose Mattos, Edward McCoul, Erik Melen, James W. Mims, Joaquim Mullol, Jayakar V. Nayak, John Oppenheimer, Richard R. Orlandi, Katie Phillips, Michael Platt, Murugappan Ramanathan Jr, Mallory Raymond, Chae‐Seo Rhee, Sietze Reitsma, Matthew Ryan, Joaquin Sastre, Rodney J. Schlosser, Theodore A. Schuman, Marcus S. Shaker, Aziz Sheikh, Kristine A. Smith, Michael B. Soyka, Masayoshi Takashima, Monica Tang, Pongsakorn Tantilipikorn, Malcolm B. Taw, Jody Tversky, Matthew A. Tyler, Maria C. Veling, Dana Wallace, De Yun Wang, Andrew White, Luo Zhang, Omar G. Ahmed, Khashayar Arianpour, Emily Barrow, Carlo Cavaliere, Juan Carlos Ceballos Cantu, Mark B. Chaskes, Andy Jian Kai Chua, Srihari Daggumati, Luke Daines, Paul Daraei, Thomas Edwards, Deanna Gigliotti, Mitchell Gore, Khodayar Goshtasbi, Doo Hee Han, Lubnaa Hossenbaccus, Megan Jolicoeur, Dichapong Kanjanawasee, Suat Kilic, Sophia Linton, David Liu, Christoper Low, Chengetai Mahomva, Jordan A. Malenke, Amar Miglani, Peter Nagy, Jin‐A Park, Marianella Paz‐Lansberg, Paul Pfeffer, Marisa Ryan, Anirudh Saraswathula, Cameron Sheehan, Nadja Struss, Kevin Tie, Sina Torabi, Esmond F. Tsai, Nathalia Velasquez, Jackson Vuncannon, Duncan Watley, Xinni Xu   +126 more
wiley   +1 more source

Key Considerations for the Development of Safe and Effective SARS‐CoV‐2 Subunit Vaccine: A Peptide‐Based Vaccine Alternative

Advanced Science, Volume 8, Issue 16, August 18, 2021., 2021
Careful antigen selection is essential for development of an effective and safe SARS‐CoV‐2 vaccine. Considering recent advances, peptide vaccines can be ideal substitutes for protein and RNA/DNA‐based vaccines. Peptide vaccines can avoid immunopathological sequences, focus immune responses on neutralizing B‐cell and on T‐cell epitopes, combine antigens
Ahmed O. Shalash, Waleed M. Hussein, Mariusz Skwarczynski, Istvan Toth   +3 more
wiley   +1 more source