Results 31 to 40 of about 584 (117)
Journal of Immunology Research, Volume 2020, Issue 1, 2020., 2020 Tuberculosis (TB) remains a major and global problem of public health. An effective TB subunit vaccine is urgently needed. Proper selection of the delivery system for the vaccine is crucial for inducing an appropriate immune response tailored to control the target pathogen.
Nadeem Ullah +8 more
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 11, 9 March 2026.The self‐adjuvanting vaccine—comprising a covalent conjugate of antigen and adjuvant—was formulated into cationic lipid nanoparticles smaller than 100 nm to facilitate uptake by immune cells, with supplemental adjuvants incorporated to modulate immune responses.
Keita Ito +9 more
wiley +2 more sources
Frontiers in Immunology, 2018 Transcriptomic profiling of the immune response induced by vaccine adjuvants is of critical importance for the rational design of vaccination strategies.
Francesco Santoro +9 more
doaj +1 more source
Protection against Chlamydia promoted by a subunit vaccine (CTH1) compared with a primary intranasal infection in a mouse genital challenge model. [PDF]
PLoS ONE, 2010 BACKGROUND: The chlamydial proteins CT443 (OmcB) and CT521 (rl16) have previously been identified as human B and/or T cell targets during a chlamydial infection in humans.
Anja Weinreich Olsen +4 more
doaj +1 more source
Selected HIV-1 Env trimeric formulations act as potent immunogens in a rabbit vaccination model. [PDF]
PLoS ONE, 2013 BACKGROUND: Ten to 30% of HIV-1 infected subjects develop broadly neutralizing antibodies (bNAbs) during chronic infection. We hypothesized that immunizing rabbits with viral envelope glycoproteins (Envs) from these patients may induce bNAbs, when ...
Leo Heyndrickx +15 more
doaj +1 more source
Frontiers in Immunology, 2019 Most microbes invading through mucosal surfaces cause disease and therefore strategies to induce mucosal immune responses are strongly needed. Vitamin A metabolites, such as retinoic acid (RA), play crucial roles in programming T and B cells to home to ...
Antonella Riccomi +5 more
doaj +1 more source
CD4 and CD8 T cell responses to the M. tuberculosis Ag85B-TB10.4 promoted by adjuvanted subunit, adenovector or heterologous prime boost vaccination. [PDF]
PLoS ONE, 2009 BackgroundAlthough CD4 T cells are crucial for defense against M.tb, it is still not clear whether the optimal response against M.tb in fact involves both CD4 and CD8 T cells.
Tara Elvang +7 more
doaj +1 more source
Journal of Immunology Research, Volume 2018, Issue 1, 2018., 2018 Induction of a robust and long‐lived mucosal immune response during vaccination is critical to achieve protection against numerous pathogens. However, traditional injected vaccines are generally poor inducers of mucosal immunity. One of the effective strategies to improve vaccine efficacy is incorporation of adjuvant molecules that enhance and polarize
Alina S. Dzharullaeva +11 more
wiley +1 more source
The Immunoregulation of Th17 in Host against Intracellular Bacterial Infection
Mediators of Inflammation, Volume 2018, Issue 1, 2018., 2018 T helper 17 cells (Th17) constitute a distinct subset of helper T cells with a unique transcriptional profile (STAT3, RORγ, and RORα), cytokine production pattern (IL17 family), and requirement of specific cytokines for their differentiation (TGF‐β, IL6, IL21, and IL23). Recent studies involving experimental animals and humans have shown that Th17/IL17
Yonghong Li +12 more
wiley +1 more source
Frontiers in Immunology, 2018 Neonates and infants are more vulnerable to infections and show reduced responses to vaccination. Consequently, repeated immunizations are required to induce protection and early life vaccines against major pathogens such as influenza are yet unavailable.
Maria Vono +13 more
doaj +1 more source