Results 31 to 40 of about 818 (145)

A liposome-based mycobacterial vaccine induces potent adult and neonatal multifunctional T cells through the exquisite targeting of dendritic cells. [PDF]

PLoS ONE, 2009
BACKGROUND: In the search for more potent and safer tuberculosis vaccines, CAF01 was identified as a remarkable formulation. Based on cationic liposomes and including a synthetic mycobacterial glycolipid as TLR-independent immunomodulator, it induces ...
Arun T Kamath, Anne-Françoise Rochat, Dennis Christensen, Else Marie Agger, Peter Andersen, Paul-Henri Lambert, Claire-Anne Siegrist   +6 more
doaj   +1 more source

Heterologous Prime-Boost Combinations Highlight the Crucial Role of Adjuvant in Priming the Immune System

Frontiers in Immunology, 2018
The induction and modulation of the immune response to vaccination can be rationally designed by combining different vaccine formulations for priming and boosting.
Annalisa Ciabattini, Elena Pettini, Fabio Fiorino, Simone Lucchesi, Gabiria Pastore, Jlenia Brunetti, Francesco Santoro, Peter Andersen, Luisa Bracci, Gianni Pozzi, Donata Medaglini   +10 more
doaj   +1 more source

Computational Analysis of Multiparametric Flow Cytometric Data to Dissect B Cell Subsets in Vaccine Studies

Cytometry Part A, Volume 97, Issue 3, Page 259-267, March 2020., 2020
The generation of the B cell response upon vaccination is characterized by the induction of different functional and phenotypic subpopulations and is strongly dependent on the vaccine formulation, including the adjuvant used. Here, we have profiled the different B cell subsets elicited upon vaccination, using machine learning methods for interpreting ...
Simone Lucchesi, Emanuele Nolfi, Elena Pettini, Gabiria Pastore, Fabio Fiorino, Gianni Pozzi, Donata Medaglini, Annalisa Ciabattini   +7 more
wiley   +1 more source

Differential Immunogenicity and Protective Efficacy Elicited by MTO‐ and DMT‐Adjuvanted CMFO Subunit Vaccines against Mycobacterium tuberculosis Infection

Journal of Immunology Research, Volume 2020, Issue 1, 2020., 2020
Tuberculosis (TB) remains a major and global problem of public health. An effective TB subunit vaccine is urgently needed. Proper selection of the delivery system for the vaccine is crucial for inducing an appropriate immune response tailored to control the target pathogen.
Nadeem Ullah, Ling Hao, Yaqi Wu, Yandi Zhang, Qing Lei, Jo-Lewis Banga Ndzouboukou, Xiaosong Lin, Xionglin Fan, Massimo Ralli   +8 more
wiley   +1 more source

The subunit vaccine H65 + CAF01 increased the BCG- protection against Mycobacterium bovis infection in a mouse model of bovine tuberculosis

, 2021
H65, a fusion protein of three pairs of ESX-secreted antigens of Mycobacterium tuberculosis and Mycobacterium bovis, formulated with the liposomal adjuvant CAF01 has been shown to confer protection against M. tuberculosis infection in mice. In this study,
Aagaard, Claus, Blanco, Federico Carlos, Bigi, Fabiana, Garcia, Elizabeth Andrea   +3 more
core   +1 more source

Programmable Antigen‐Specific Immunity via Self‐Adjuvanting Nanovaccines Co‐Delivering Immune Modulators

Angewandte Chemie, Volume 138, Issue 11, 9 March 2026.
The self‐adjuvanting vaccine—comprising a covalent conjugate of antigen and adjuvant—was formulated into cationic lipid nanoparticles smaller than 100 nm to facilitate uptake by immune cells, with supplemental adjuvants incorporated to modulate immune responses.
Keita Ito, Yoshiyuki Manabe, Shino Ohshima, Masatoshi Maeki, Manabu Tokeshi, Hiroshi Inaba, Kazunori Matsuura, Kazuya Kabayama, Yoshie Kametani, Koichi Fukase   +9 more
wiley   +2 more sources

Transcriptomics of the Vaccine Immune Response: Priming With Adjuvant Modulates Recall Innate Responses After Boosting

Frontiers in Immunology, 2018
Transcriptomic profiling of the immune response induced by vaccine adjuvants is of critical importance for the rational design of vaccination strategies.
Francesco Santoro, Elena Pettini, Dmitri Kazmin, Annalisa Ciabattini, Fabio Fiorino, Gregor D. Gilfillan, Ida M. Evenroed, Peter Andersen, Gianni Pozzi, Donata Medaglini   +9 more
doaj   +1 more source

Selected HIV-1 Env trimeric formulations act as potent immunogens in a rabbit vaccination model. [PDF]

PLoS ONE, 2013
BACKGROUND: Ten to 30% of HIV-1 infected subjects develop broadly neutralizing antibodies (bNAbs) during chronic infection. We hypothesized that immunizing rabbits with viral envelope glycoproteins (Envs) from these patients may induce bNAbs, when ...
Leo Heyndrickx, Guillaume Stewart-Jones, Marianne Jansson, Hanneke Schuitemaker, Emma Bowles, Luigi Buonaguro, Berit Grevstad, Lasse Vinner, Katleen Vereecken, Joe Parker, Meghna Ramaswamy, Priscilla Biswas, Guido Vanham, Gabriella Scarlatti, Anders Fomsgaard, NGIN Consortium   +15 more
doaj   +1 more source

Protection against Chlamydia promoted by a subunit vaccine (CTH1) compared with a primary intranasal infection in a mouse genital challenge model. [PDF]

PLoS ONE, 2010
BACKGROUND: The chlamydial proteins CT443 (OmcB) and CT521 (rl16) have previously been identified as human B and/or T cell targets during a chlamydial infection in humans.
Anja Weinreich Olsen, Michael Theisen, Dennis Christensen, Frank Follmann, Peter Andersen   +4 more
doaj   +1 more source

The IPV-CAF01 formulation.

, 2014
A. The Zavg hydrodynamic diameter of IPV3 (2237 DU/ml), IPV TP (400∶80∶320 DU), CAF01 (2500DDA/500TDB) and IPV (8DU)-CAF01 (2500DDA/500TDB). All data show the average of 3 measurements. B.
Else Marie Agger (104700), Peter Andersen (88335), Lars Vibe Andreasen (582339), Jes Dietrich (154335)   +3 more
core   +1 more source