Results 51 to 60 of about 1,231 (164)

Mycobacterium tuberculosis antigen 85B and ESAT-6 expressed as a recombinant fusion protein in Mycobacterium smegmatis elicits cell-mediated immune response in a murine vaccination model [PDF]

, 2013
This is the post-print version of the final paper published in Molecular Immunology. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting ...
Aagaard, Agger, Andersen, Andersen, Anthony G. Tsolaki, Bennekov, Blokpoel, Brian D. Robertson, Carroll, Crowe, Curcic, Delogu, Delogu, DeMaio, Dietrich, Dye, Dziadek, Ehrt, Fine, Garbe, Gupta, Hanekom, Ida Rosenkrands, Judit Nagy, Laemmli, Langermans, Maher, Masungi, Menozzi, Menozzi, Okkels, Olsen, O’Donnell, Parish, Pethe, Roche, Russell, Sambrook, Sergio Leiva, Temmerman, Triccas, Triccas, Tsolaki, Uday Kishore, van Dissel, van Dissel, Weinrich Olsen, Wiles, Williams   +48 more
core   +1 more source

Simultaneous Subcutaneous and Intranasal Administration of a CAF01-Adjuvanted Chlamydia Vaccine Elicits Elevated IgA and Protective Th1/Th17 Responses in the Genital Tract [PDF]

Frontiers in Immunology, 2017
The selection of any specific immunization route is critical when defining future vaccine strategies against a genital infection like Chlamydia trachomatis (C.t.). An optimal Chlamydia vaccine needs to elicit mucosal immunity comprising both neutralizing IgA/IgG antibodies and strong Th1/Th17 responses.
Wern, Jeanette Erbo, Sorensen, Maria Rathmann, Olsen, Anja Weinreich, Andersen, Peter, Follmann, Frank   +4 more
openaire   +3 more sources

Transcriptomics of the Vaccine Immune Response: Priming With Adjuvant Modulates Recall Innate Responses After Boosting

Frontiers in Immunology, 2018
Transcriptomic profiling of the immune response induced by vaccine adjuvants is of critical importance for the rational design of vaccination strategies.
Francesco Santoro, Elena Pettini, Dmitri Kazmin, Annalisa Ciabattini, Fabio Fiorino, Gregor D. Gilfillan, Ida M. Evenroed, Peter Andersen, Gianni Pozzi, Donata Medaglini   +9 more
doaj   +1 more source

Beyond antigens and adjuvants: formulating future vaccines [PDF]

, 2016
The need to optimize vaccine potency while minimizing toxicity in healthy recipients has motivated studies of the formulation of vaccines to control how, when, and where antigens and adjuvants encounter immune cells and other cells/tissues following ...
Ali, Andrew C. Zmolek, Benson, Boato, Darrell J. Irvine, Desch, Dhodapkar, Dupuis, Garaude, Hanson, Kool, Li, Malyala, Mancini, Pulendran, Ross, Tyson J. Moyer   +16 more
core   +1 more source

Protection against Chlamydia promoted by a subunit vaccine (CTH1) compared with a primary intranasal infection in a mouse genital challenge model. [PDF]

PLoS ONE, 2010
BACKGROUND: The chlamydial proteins CT443 (OmcB) and CT521 (rl16) have previously been identified as human B and/or T cell targets during a chlamydial infection in humans.
Anja Weinreich Olsen, Michael Theisen, Dennis Christensen, Frank Follmann, Peter Andersen   +4 more
doaj   +1 more source

Safety and immunogenicity of H1/IC31®, an adjuvanted TB subunit vaccine, in HIV-infected adults with CD4+ lymphocyte counts greater than 350 cells/mm3: a phase II, multi-centre, double-blind, randomized, placebo-controlled trial. [PDF]

, 2014
BACKGROUND: Novel tuberculosis vaccines should be safe, immunogenic, and effective in various population groups, including HIV-infected individuals. In this phase II multi-centre, double-blind, placebo-controlled trial, the safety and immunogenicity of ...
Andersen, Peter, Bang, Peter, Beattie, Trevor, Churchyard, Gavin J., Daubenberger, Claudia, Fielding, Katherine L., Gardiner, Nicolene, Hanekom, Willem A., Hoff, Søren T., Hughes, Elisabeth J., Jeffery, Hannah, Kagina, Benjamin M., Katsoulis, Lynn, Kromann, Ingrid, Landay, Alan, Lenz, Nicole, Mfinanga, Elirehema, Pohl, Christian, Reither, Klaus, Said, Khadija, Scriba, Thomas J.   +20 more
core   +5 more sources

Dynamics of Mycobacterium tuberculosis Ag85B Revealed by a Sensitive Enzyme-Linked Immunosorbent Assay. [PDF]

, 2019
Secretion of specific proteins contributes to pathogenesis and immune responses in tuberculosis and other bacterial infections, yet the kinetics of protein secretion and fate of secreted proteins in vivo are poorly understood. We generated new monoclonal
Bolz, Miriam, Cornelius, Amber, Ernst, Joel D   +2 more
core   +2 more sources

Selected HIV-1 Env trimeric formulations act as potent immunogens in a rabbit vaccination model. [PDF]

PLoS ONE, 2013
BACKGROUND: Ten to 30% of HIV-1 infected subjects develop broadly neutralizing antibodies (bNAbs) during chronic infection. We hypothesized that immunizing rabbits with viral envelope glycoproteins (Envs) from these patients may induce bNAbs, when ...
Leo Heyndrickx, Guillaume Stewart-Jones, Marianne Jansson, Hanneke Schuitemaker, Emma Bowles, Luigi Buonaguro, Berit Grevstad, Lasse Vinner, Katleen Vereecken, Joe Parker, Meghna Ramaswamy, Priscilla Biswas, Guido Vanham, Gabriella Scarlatti, Anders Fomsgaard, NGIN Consortium   +15 more
doaj   +1 more source

Th1 immune responses can be modulated by varying dimethyldioctadecylammonium and distearoyl-sn-glycero-3-phosphocholine content in liposomal adjuvants [PDF]

, 2014
OBJECTIVES: Cationic liposomes of dimethyldioctadecylammonium bromide (DDA) combined with trehalose 6,6'-dibehenate (TDB) elicit strong cell-mediated and antibody immune responses; DDA facilitates antigen adsorption and presentation while TDB potentiates
Bramwell, Vincent W., Christensen, Dennis, Hussain, Mohammed Jubair, Perrie, Yvonne, Wilkinson, Alexander   +4 more
core   +1 more source

Stimulation of Dectin‐1 and Dectin‐2 during Parenteral Immunization, but Not Mincle, Induces Secretory IgA in Intestinal Mucosa

Journal of Immunology Research, Volume 2018, Issue 1, 2018., 2018
Induction of a robust and long‐lived mucosal immune response during vaccination is critical to achieve protection against numerous pathogens. However, traditional injected vaccines are generally poor inducers of mucosal immunity. One of the effective strategies to improve vaccine efficacy is incorporation of adjuvant molecules that enhance and polarize
Alina S. Dzharullaeva, Amir I. Tukhvatulin, Alina S. Erokhova, Alina S. Bandelyuk, Nikita B. Polyakov, Andrey I. Solovyev, Natalia A. Nikitenko, Dmitry V. Shcheblyakov, Boris S. Naroditsky, Denis Y. Logunov, Alexander L. Gintsburg, Manoj K. Mishra   +11 more
wiley   +1 more source