The cationic liposomal adjuvants CAF01 and CAF09 formulated with the major outer membrane protein elicit robust protection in mice against a Chlamydia muridarum respiratory challenge [PDF]
, 2017 Two cationic liposomal adjuvants CAF01 and CAF09 were formulated with the native or the recombinant Chlamydia muridarum major outer membrane protein (nMOMP and rMOMP).
Andersen, Peter +9 more
core +1 more source
Modulation of primary immune response by different vaccine adjuvants
Frontiers in Immunology, 2016 Adjuvants contribute to enhancing and shaping the vaccine immune response through different modes of action. Since the primary immune response can influence the overall quality of the response generated, here we investigate early biomarkers of ...
Annalisa Ciabattini +6 more
doaj +1 more source
Frontiers in Immunology, 2017 There is an unmet need for a vaccine to control Chlamydia trachomatis (C.t.) infections. We have recently designed a multivalent heterologous immuno-repeat 1 (Hirep1) vaccine construct based on major outer membrane protein variable domain (VD) 4 regions ...
Anja Weinreich Olsen +4 more
doaj +1 more source
PLoS ONE, 2010 Bioneedles are small hollow sugar based needles administered with a simple compressed air device. In the present study we investigate how incorporation of a subunit vaccine based on TB vaccine hybrid Ag85B-ESAT-6 adjuvated with CAF01 into Bioneedles ...
Dennis Christensen +4 more
doaj +1 more source
Ag85B-ESAT-6/CAF01 protects neonates and adults from mycobacterial infection.
, 2013 Immunized neonatal and adult mice were challenged with Mycobacterium bovis BCG i.v. The CFU in spleen (A) and lung (B) (mean and SD, 6–8/group) were determined four weeks later, and is representative of 2 independent experiments ...
Dennis Christensen (104693) +6 more
core +1 more source
CAF01-induced responses in TLR2, 3, 4, 7 and MyD88-deficient mice.
, 2013 A) MyD88-/- and B) TLR2, 3, 4, 7-/- mice as well as WT controls mice (n = 3) were vaccinated twice with 2 µg of Ag85B-ESAT-6 in CAF01 by footpad immunization.
Kerstin Werninghaus (104676) +12 more
core +1 more source
Peptide-specific T helper cells identified by MHC class II tetramers differentiate into several subtypes upon immunization with CAF01 adjuvanted H56 tuberculosis vaccine formulation [PDF]
, 2015 CD4(+) T-cell priming is an essential step in vaccination due to the key role of T helper cells in driving both effector and memory immune responses. Here we have characterized in C57BL/6 mice the T helper subtype differentiation among tetramer-specific ...
Andersen, Peter +4 more
core +1 more source
High Antigen Dose Is Detrimental to Post-Exposure Vaccine Protection against Tuberculosis
Frontiers in Immunology, 2018 Mycobacterium tuberculosis (Mtb), the etiologic agent of tuberculosis (TB), causes 1.8M deaths annually. The current vaccine, BCG, has failed to eradicate TB leaving 25% of the world’s population with latent Mtb infection (LTBI), and 5–10% of these ...
Rolf Billeskov +8 more
doaj +1 more source
CAF05 enhances Gag p24 specific antibodies to the same level as CAF01.
, 2013 Mice were immunized three times i.p. with 20 µg Gag p24 protein alone (open triangles) or adjuvanted in either CAF01 (black circles) or CAF05 (open circles). Naïve mice were used as a negative control (black triangles).
Karen S. Korsholm (582490) +7 more
core +1 more source
Scientific Reports, 2017 In an effort to reduce the frequency and severity of adverse reactions seen from the use of mineral oil adjuvants in salmonid fish, the effects of two alternative adjuvants were assessed, focusing on the induction of adverse effects as well as protection.
Kasper Rømer Villumsen +3 more
doaj +1 more source