Results 71 to 80 of about 1,231 (164)
Angewandte Chemie International Edition, Volume 65, Issue 11, 9 March 2026.The self‐adjuvanting vaccine—comprising a covalent conjugate of antigen and adjuvant—was formulated into cationic lipid nanoparticles smaller than 100 nm to facilitate uptake by immune cells, with supplemental adjuvants incorporated to modulate immune responses.
Keita Ito +9 more
wiley +1 more source
Tuberculosis Research and Treatment, Volume 2011, Issue 1, 2011., 2011 Mycobacterium bovis bacille Calmette‐Guérin (BCG) is the only available vaccine for tuberculosis (TB). Although this vaccine is effective in controlling infantile TB, BCG‐induced protective effects against pulmonary diseases in adults have not been clearly demonstrated.
Kazuhiro Matsuo +2 more
wiley +1 more source
Principales sistemas de entrega de antígenos en Medicina Veterinaria y Humana [PDF]
, 2014 Las vacunas modernas se basan generalmente en proteínas recombinantes altamente purificadas. Esta alta pureza representa uno de los mayores avances en términos de seguridad, en comparación a las estrategias de vacunación tradicionales basadas en ...
Siel, Daniela +2 more
core +2 more sources
PLoS ONE, 2018 There is a need for the rational design of safe and effective vaccines to protect against chronic bacterial pathogens such as Mycobacterium tuberculosis and Mycobacterium avium subsp. paratuberculosis in a number of species.
Aneesh Thakur +6 more
doaj +1 more source
Intranasal vaccination with killed Leishmania amazonensis promastigotes antigen (LaAg) associated with CAF01 adjuvant induces partial protection in BALB/c mice challenged with Leishmania (infantum) chagasi. [PDF]
Parasitology, 2015 SUMMARY The CAF01 adjuvant has previously been shown to be safe for human use and to be a potent adjuvant for several vaccine antigens. In the present work, we sought to optimize the Leishmania amazonensis antigens (LaAg) intranasal vaccine in an attempt to enhance the ...
JANINE MIRANDA LEAL +8 more
openaire +1 more source
Frontiers in Immunology, 2022 Successful subunit vaccination with recombinant proteins requires adjuvants. The glycolipid trehalose-dibehenate (TDB), a synthetic analog of the mycobacterial cord factor, potently induces Th1 and Th17 immune responses and is a candidate adjuvant for ...
Christiane Desel +9 more
doaj +1 more source
Immunology &Cell Biology, Volume 103, Issue 9, Page 825-843, October 2025.Therapeutic cancer vaccines require CD8+ T‐cell activation for efficacy. This response can be enhanced by rationally designing polymeric nanoparticle adjuvants. The importance of antigen location for the adjuvanticity of polymeric nanoparticles has not been fully resolved.
Jorge Huete‐Carrasco +6 more
wiley +1 more source
Genital Chlamydia trachomatis: understanding the roles of innate and adaptive immunity in vaccine research. [PDF]
, 2014 Chlamydia trachomatis is the leading cause of bacterial sexually transmitted disease worldwide, and despite significant advances in chlamydial research, a prophylactic vaccine has yet to be developed.
Baud, D. +3 more
core +1 more source
European Journal of Immunology, Volume 54, Issue 6, June 2024.Intranasal administration of spike protein antigen alone following an intramuscular prime with spike protein antigen adjuvanted with sulfated lactosylarchaeol (SLA) archaeosomes boosts systemic and mucosal immune responses, leading to protection from SARS‐CoV‐2 infection.
Gerard Agbayani +13 more
wiley +1 more source
Correlating liposomal adjuvant characteristics to in-vivo cell-mediated immunity using a novel Mycobacterium tuberculosis fusion protein : a multivariate analysis study [PDF]
, 2015 OBJECTIVE: In this study, we have used a chemometrics-based method to correlate key liposomal adjuvant attributes with in-vivo immune responses based on multivariate analysis.
Bramwell, Vincent W. +4 more
core +1 more source