Results 81 to 90 of about 818 (145)

Investigating Prime-Pull Vaccination through a Combination of Parenteral Vaccination and Intranasal Boosting

Vaccines, 2019
Formulation of inhalable delivery systems containing tuberculosis (TB) antigens to target the site of infection (lungs) have been considered for the development of subunit vaccines. Inert delivery systems such as poly (lactic-co-glycolic acid) (PLGA) are
Carla B. Roces, Maryam T. Hussain, Signe T. Schmidt, Dennis Christensen, Yvonne Perrie   +4 more
doaj   +1 more source

Cellular immune responses are induced to a similar level after immunization with IFA and CAF01.

, 2013
IFN-γ ELISPOT responses against (A) HLA-A2-restricted CD8 T cell epitope Vif101 and (B) PADRE Th epitope of splenocytes from HLA-A*0201 transgenic HHD mice after 10 days of s.c. immunization with Vif101 and PADRE in either IFA (grey bars, n = 5) or CAF01
Else Marie Agger (104700), Peter Andersen (88335), Ingrid Karlsson (85751), Gregers Jacob Gram (370609), Anders Fomsgaard (24125)   +4 more
core   +1 more source

Proliferative CD8⁺ T cell responses induced after immunization with IFA and CAF01.

, 2013
The percentage of proliferating CD3+CD8+ splenocytes (having reduced CFSE dye) derived from HLA-A*0201 transgenic HHD mice 10 days after s.c. immunization with a peptide mix consisting of 10 peptides adjuvanted with (A) IFA or (B) CAF01.
Else Marie Agger (104700), Peter Andersen (88335), Ingrid Karlsson (85751), Gregers Jacob Gram (370609), Anders Fomsgaard (24125)   +4 more
core   +1 more source

CAF01 adjuvant increases the protection conferred by a commercially available influenza split vaccine in a ferret model

, 2009
The immunogenicity and efficacy of preventive vaccines against influenza are considered suboptimal and the development of novel influenza vaccination strategies is urgently needed.
Jensen, Trine Hammer, Martel, Cyril, Andersen, Peter, Agger, Else-Marie, Blixenkrone-Møller, Merete, Nielsen, Lars Peter, Aasted, Bent   +6 more
core   +1 more source

Lactobacillus plantarum producing a Chlamydia trachomatis antigen induces a specific IgA response after mucosal booster immunization.

PLoS ONE, 2017
Mucosal immunity is important for the protection against a wide variety of pathogens. Traditional vaccines administered via parenteral routes induce strong systemic immunity, but they often fail to generate mucosal IgA.
Katarzyna Kuczkowska, Ine Myrbråten, Lise Øverland, Vincent G H Eijsink, Frank Follmann, Geir Mathiesen, Jes Dietrich   +6 more
doaj   +1 more source

Toll like-receptor agonist Pam3Cys modulates the immunogenicity of liposomes containing the tuberculosis vaccine candidate H56

, 2020
A major roadblock in the development of novel vaccines is the formulation and delivery of the antigen. Liposomes composed of a dimethyldioctadecylammonium (DDA) backbone and the adjuvant trehalose-6-6-dibehenate (TDB, termed 'cationic adjuvant ...
Grieshober, Mark, Kennerknecht, Kathrin, Noschka, Reiner, Stenger, Steffen, Christensen, Dennis, Mayer, Daniel, Wehrstedt, Stephanie, Pedersen, Gabriel Kristian, Löffler, Florian   +8 more
core   +1 more source

Data_Sheet_1_Dual-Isotope SPECT/CT Imaging of the Tuberculosis Subunit Vaccine H56/CAF01: Induction of Strong Systemic and Mucosal IgA and T-Cell Responses in Mice Upon Subcutaneous Prime and Intrapulmonary Boost Immunization.docx

, 2018
Pulmonary tuberculosis (TB), which is caused by Mycobacterium tuberculosis (Mtb), remains a global pandemic, despite the widespread use of the parenteral live attenuated Bacillus Calmette–Guérin (BCG) vaccine during the past decades.
Dennis Christensen (104693), Aneesh Thakur (5575139), Zeynab Nosrati (6031517), Katayoun Saatchi (2100859), Peter Andersen (88335), Fabrice Rose (4054681), Camilla Foged (2101978), Cristina Rodríguez-Rodríguez (6031511), Tullio Esposito (6031514), Urs O. Häfeli (335701)   +9 more
core   +1 more source

Image_1_Dual-Isotope SPECT/CT Imaging of the Tuberculosis Subunit Vaccine H56/CAF01: Induction of Strong Systemic and Mucosal IgA and T-Cell Responses in Mice Upon Subcutaneous Prime and Intrapulmonary Boost Immunization.JPEG

, 2018
Pulmonary tuberculosis (TB), which is caused by Mycobacterium tuberculosis (Mtb), remains a global pandemic, despite the widespread use of the parenteral live attenuated Bacillus Calmette–Guérin (BCG) vaccine during the past decades.
Dennis Christensen (104693), Aneesh Thakur (5575139), Zeynab Nosrati (6031517), Katayoun Saatchi (2100859), Peter Andersen (88335), Fabrice Rose (4054681), Camilla Foged (2101978), Cristina Rodríguez-Rodríguez (6031511), Tullio Esposito (6031514), Urs O. Häfeli (335701)   +9 more
core   +1 more source

Immune responses and protection induced by CAF01 in a malaria blood-stage model.

, 2013
BALB/c mice were immunized three times with 10 µg of MSP1 in CAF01 or Al(OH)3. One week after the last immunization, mice were bled by periorbital puncture and individual sera tested for MSP1-specific A) IgG1 or B) IgG2a by ELISA (n = 5).
Kerstin Werninghaus (104676), Roland Lang (77155), Jon Hansen (16978), Michael Theisen (81720), Claus Aagaard (263500), Dennis Christensen (104693), Else Marie Agger (104700), Brian S. Vandahl (376819), Peter Andersen (88335), Frank Follmann (248464), Ida Rosenkrands (299547), Carsten Kirschning (104698), Karima Brahimi (376818)   +12 more
core   +1 more source

Ag85B-ESAT-6/CAF01 stimulates production of multifunctional CD4⁺ T cells in neonates and adults.

, 2013
The expression of IFN-γ, IL-2 and TNF-α was determined by ICS on splenocytes from neonatal and adult mice, 6 weeks and 6 months post-boost. Cytokine production was only detected in CD4+ T cells from Ag/CAF01-immunized mice stimulated with antigen.
Dennis Christensen (104693), Else Marie Agger (104700), Anne-Françoise Rochat (372435), Peter Andersen (88335), Claire-Anne Siegrist (146625), Paul-Henri Lambert (372438), Arun T. Kamath (372434)   +6 more
core   +1 more source