Results 61 to 70 of about 1,231 (164)
Frontiers in Immunology, 2019 Most microbes invading through mucosal surfaces cause disease and therefore strategies to induce mucosal immune responses are strongly needed. Vitamin A metabolites, such as retinoic acid (RA), play crucial roles in programming T and B cells to home to ...
Antonella Riccomi +5 more
doaj +1 more source
The Immunoregulation of Th17 in Host against Intracellular Bacterial Infection
Mediators of Inflammation, Volume 2018, Issue 1, 2018., 2018 T helper 17 cells (Th17) constitute a distinct subset of helper T cells with a unique transcriptional profile (STAT3, RORγ, and RORα), cytokine production pattern (IL17 family), and requirement of specific cytokines for their differentiation (TGF‐β, IL6, IL21, and IL23). Recent studies involving experimental animals and humans have shown that Th17/IL17
Yonghong Li +12 more
wiley +1 more source
Vaccine Adjuvants Differentially Affect Kinetics of Antibody and Germinal Center Responses
Frontiers in Immunology, 2020 Aluminum salts and squalene based oil-in-water emulsions (SE) are widely used adjuvants in licensed vaccines, yet their mechanisms are not fully known.
Gabriel Kristian Pedersen +4 more
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CD4 and CD8 T cell responses to the M. tuberculosis Ag85B-TB10.4 promoted by adjuvanted subunit, adenovector or heterologous prime boost vaccination. [PDF]
PLoS ONE, 2009 BackgroundAlthough CD4 T cells are crucial for defense against M.tb, it is still not clear whether the optimal response against M.tb in fact involves both CD4 and CD8 T cells.
Tara Elvang +7 more
doaj +1 more source
Frontiers in Immunology, 2018 Neonates and infants are more vulnerable to infections and show reduced responses to vaccination. Consequently, repeated immunizations are required to induce protection and early life vaccines against major pathogens such as influenza are yet unavailable.
Maria Vono +13 more
doaj +1 more source
Mucosal Vaccine Development Based on Liposome Technology
Journal of Immunology Research, Volume 2016, Issue 1, 2016., 2016 Immune protection against infectious diseases is most effective if located at the portal of entry of the pathogen. Hence, there is an increasing demand for vaccine formulations that can induce strong protective immunity following oral, respiratory, or genital tract administration.
Valentina Bernasconi +5 more
wiley +1 more source
Nanomedicines for the delivery of biologics [PDF]
, 2019 A special symposium of the Academy of Pharmaceutical Sciences Nanomedicines Focus Group reviewed the current status of the use of nanomedicines for the delivery of biologics drugs.
Desai, Arpan +10 more
core +6 more sources
EBioMedicine, 2018 Despite inducing strong T cell responses, Mycobacterium tuberculosis (Mtb) infection fails to elicit protective immune memory. As such latently infected or successfully treated Tuberculosis (TB) patients are not protected against recurrent disease. Here,
Thomas Lindenstrøm +5 more
doaj +1 more source
Malaria Vaccine Adjuvants: Latest Update and Challenges in Preclinical and Clinical Research
BioMed Research International, Volume 2013, Issue 1, 2013., 2013 There is no malaria vaccine currently available, and the most advanced candidate has recently reported a modest 30% efficacy against clinical malaria. Although many efforts have been dedicated to achieve this goal, the research was mainly directed to identify antigenic targets.
Elena Mata +5 more
wiley +1 more source
Scientific Reports, 2022 Liposomes are a strong supporting tool in vaccine technology, as they are a versatile system that not only act as antigen delivery systems but also adjuvants that can be highly effective at stimulating both innate and adaptive immune responses.
Laura A. J. Feather +5 more
doaj +1 more source