Results 61 to 70 of about 584 (117)

Protective Effect of Vaccine Promoted Neutralizing Antibodies against the Intracellular Pathogen Chlamydia trachomatis

Frontiers in Immunology, 2017
There is an unmet need for a vaccine to control Chlamydia trachomatis (C.t.) infections. We have recently designed a multivalent heterologous immuno-repeat 1 (Hirep1) vaccine construct based on major outer membrane protein variable domain (VD) 4 regions ...
Anja Weinreich Olsen, Emma Kathrine Lorenzen, Ida Rosenkrands, Frank Follmann, Peter Andersen   +4 more
doaj   +1 more source

Syringe free vaccination with CAF01 Adjuvated Ag85B-ESAT-6 in Bioneedles provides strong and prolonged protection against tuberculosis.

PLoS ONE, 2010
Bioneedles are small hollow sugar based needles administered with a simple compressed air device. In the present study we investigate how incorporation of a subunit vaccine based on TB vaccine hybrid Ag85B-ESAT-6 adjuvated with CAF01 into Bioneedles ...
Dennis Christensen, Thomas Lindenstrøm, Gijsbert van de Wijdeven, Peter Andersen, Else Marie Agger   +4 more
doaj   +1 more source

High Antigen Dose Is Detrimental to Post-Exposure Vaccine Protection against Tuberculosis

Frontiers in Immunology, 2018
Mycobacterium tuberculosis (Mtb), the etiologic agent of tuberculosis (TB), causes 1.8M deaths annually. The current vaccine, BCG, has failed to eradicate TB leaving 25% of the world’s population with latent Mtb infection (LTBI), and 5–10% of these ...
Rolf Billeskov, Thomas Lindenstrøm, Joshua Woodworth, Cristina Vilaplana, Pere-Joan Cardona, Joseph P. Cassidy, Rasmus Mortensen, Else Marie Agger, Peter Andersen   +8 more
doaj   +1 more source

Alternatives to mineral oil adjuvants in vaccines against Aeromonas salmonicida subsp. salmonicida in rainbow trout offer reductions in adverse effects

Scientific Reports, 2017
In an effort to reduce the frequency and severity of adverse reactions seen from the use of mineral oil adjuvants in salmonid fish, the effects of two alternative adjuvants were assessed, focusing on the induction of adverse effects as well as protection.
Kasper Rømer Villumsen, Erling Olaf Koppang, Dennis Christensen, Anders Miki Bojesen   +3 more
doaj   +1 more source

Investigating Prime-Pull Vaccination through a Combination of Parenteral Vaccination and Intranasal Boosting

Vaccines, 2019
Formulation of inhalable delivery systems containing tuberculosis (TB) antigens to target the site of infection (lungs) have been considered for the development of subunit vaccines. Inert delivery systems such as poly (lactic-co-glycolic acid) (PLGA) are
Carla B. Roces, Maryam T. Hussain, Signe T. Schmidt, Dennis Christensen, Yvonne Perrie   +4 more
doaj   +1 more source

Lactobacillus plantarum producing a Chlamydia trachomatis antigen induces a specific IgA response after mucosal booster immunization.

PLoS ONE, 2017
Mucosal immunity is important for the protection against a wide variety of pathogens. Traditional vaccines administered via parenteral routes induce strong systemic immunity, but they often fail to generate mucosal IgA.
Katarzyna Kuczkowska, Ine Myrbråten, Lise Øverland, Vincent G H Eijsink, Frank Follmann, Geir Mathiesen, Jes Dietrich   +6 more
doaj   +1 more source

Phosphatidylinositolmannoside vaccination induces lipid-specific Th1-responses and partially protects guinea pigs from Mycobacterium tuberculosis challenge. [PDF]

Sci Rep, 2023
Eckhardt E, Schinköthe J, Gischke M, Sehl-Ewert J, Corleis B, Dorhoi A, Teifke J, Albrecht D, Geluk A, Gilleron M, Bastian M.   +10 more
europepmc   +1 more source

Head-to-Head Comparison of Novel Vaccine Technologies Comes with a Minefield of Challenges. [PDF]

Pharmaceutics, 2023
Christensen D.
europepmc   +1 more source

A protective, single-visit TB vaccination regimen by co-administration of a subunit vaccine with BCG. [PDF]

NPJ Vaccines, 2023
Dijkman K, Lindenstrøm T, Rosenkrands I, Søe R, Woodworth JS, Lindestam Arlehamn CS, Mortensen R.   +6 more
europepmc   +1 more source

IL-4 and helminth infection downregulate MINCLE-dependent macrophage response to mycobacteria and Th17 adjuvanticity. [PDF]

Elife, 2023
Schick J, Altunay M, Lacorcia M, Marschner N, Westermann S, Schluckebier J, Schubart C, Bodendorfer B, Christensen D, Alexander C, Wirtz S, Voehringer D, da Costa CP, Lang R.   +13 more
europepmc   +1 more source