Results 61 to 70 of about 818 (145)

Local Th17/IgA immunity correlate with protection against intranasal infection with Streptococcus pyogenes. [PDF]

PLoS ONE, 2017
Streptococcus pyogenes (group A streptococcus, GAS) is responsible for a wide array of infections. Respiratory transmission via droplets is the most common mode of transmission but it may also infect the host via other routes such as lesions in the skin.
Rasmus Mortensen, Dennis Christensen, Lasse Bøllehuus Hansen, Jan Pravsgaard Christensen, Peter Andersen, Jes Dietrich   +5 more
doaj   +1 more source

Kinetics of Ag85B-ESAT-6 and CAF01 labeled DC in the draining LN of adults and neonates.

, 2013
At various time points after immunization, the number of Ag85-ESAT-6+ CAF01+ DC and Ag85-ESAT-6− CAF01+ DC was calculated.
Dennis Christensen (104693), Else Marie Agger (104700), Anne-Françoise Rochat (372435), Peter Andersen (88335), Claire-Anne Siegrist (146625), Paul-Henri Lambert (372438), Arun T. Kamath (372434)   +6 more
core   +1 more source

Optimisation of a murine splenocyte mycobacterial growth inhibition assay using virulent Mycobacterium tuberculosis

Scientific Reports, 2017
In the absence of a validated correlate of protection or robust animal models for human tuberculosis, Mycobacterial growth inhibition assays (MGIAs) aim to assess vaccines ability to inhibit mycobacterial growth in-vitro.
Christina Jensen, Line Lindebo Holm, Erik Svensson, Claus Aagaard, Morten Ruhwald   +4 more
doaj   +1 more source

A novel liposomal adjuvant system, CAF01, promotes long-lived Mycobacterium tuberculosis-specific T-cell responses in human [PDF]

, 2014
Here, we report on a first-in-man trial where the tuberculosis (TB) vaccine Ag85B-ESAT-6 (H1) was adjuvanted with escalating doses of a novel liposome adjuvant CAF01.
Kromann, I., Soonawala, D., Hoff, Søren T., Joosten, Simone A., Visser, A.W. de, Ruhwald, Morten, Soonawala, Darius, Thierry-Carstensen, Birgit, Ottenhoff, Tom H.M., Graves, Andrew, O'Dee, D.M., Ottenhoff, T.H.M., Andersen, Peter, Joosten, S.A., Graves, A., Hokey, D.A., de Visser, Adriëtte W., Agger, Else Marie, Andreasen, L.V., Prins, Corine, Kromann, Ingrid, Ruhwald, M., Andersen, P., Thierry-Carstensen, B., Hoff, S.T., Agger, E.M., Hokey, David A., O’Dee, Dawn M., van Dissel, Jaap T., Andreasen, Lars V., Dissel, J.T. van, Prins, C.   +31 more
core   +1 more source

Intramuscular priming and intranasal boosting induce strong genital immunity through secretory IgA in minipigs infected with Chlamydia trachomatis

Frontiers in Immunology, 2015
International efforts in developing a vaccine against Chlamydia trachomatis have highlighted the need for novel immunization strategies for the induction of genital immunity. In this study, we evaluated an intramuscular prime/intranasal boost vaccination
Emma eLorenzen, Emma eLorenzen, Frank eFollmann, Sarah eBøje, Sarah eBøje, Karin eErneholm, Karin eErneholm, Anja Weinreich Olsen, Jørgen Steen Agerholm, Gregers eJungersen, Peter eAndersen   +10 more
doaj   +1 more source

Ag85B-ESAT-6-specific T cell responses following neonatal and adult immunization with Ag85B-ESAT-6 in the CAF01 adjuvant.

, 2013
aIFN-γ secreting cells (ISC)/106 splenocytes were determined after 48 hr of culture with antigen and IL-2 (bioassay), TNF-α, IL-17, IFN-γ and IL-5 (ELISA) after 72 hr of culture with antigen.
Dennis Christensen (104693), Else Marie Agger (104700), Anne-Françoise Rochat (372435), Peter Andersen (88335), Claire-Anne Siegrist (146625), Paul-Henri Lambert (372438), Arun T. Kamath (372434)   +6 more
core   +1 more source

Liposome-based cationic adjuvant CAF01 enhances the protection conferred by a commercial inactivated influenza vaccine in ferrets

, 2009
Objectives: To assess the effect of CAF01 adjuvant associated to a commercial trivalent inactivated influenza vaccine in the ferret model. Methods:  Ferrets were vaccinated with a range of doses of Sanofi-Pasteur's Vaxigrip with or without the CAF01 ...
Jensen, Trine Hammer, Andersen, Peter, Martel, Cyril Jean-Marie, Blixenkrone-Møller, Merete, Nielsen, Lars Peter, Agger, Else Marie, Aasted, Bent   +6 more
core   +1 more source

Cross-Protective Potential and Protection-Relevant Immune Mechanisms of Whole Inactivated Influenza Virus Vaccines Are Determined by Adjuvants and Route of Immunization

Frontiers in Immunology, 2019
Adjuvanted whole inactivated virus (WIV) influenza vaccines show promise as broadly protective influenza vaccine candidates. Using WIV as basis we assessed the relative efficacy of different adjuvants by carrying out a head-to-head comparison of the ...
Yoshita Bhide, Wei Dong, Inta Gribonika, Daniëlle Voshart, Tjarko Meijerhof, Jacqueline de Vries-Idema, Stephen Norley, Kate Guilfoyle, Sarah Skeldon, Othmar G. Engelhardt, Louis Boon, Dennis Christensen, Nils Lycke, Anke Huckriede   +13 more
doaj   +1 more source

Testing the H56 Vaccine Delivered in 4 Different Adjuvants as a BCG-Booster in a Non-Human Primate Model of Tuberculosis. [PDF]

PLoS ONE, 2016
The search for new and improved tuberculosis (TB) vaccines has focused on IFN-γ both for selecting antigens and for evaluating vaccine delivery strategies.
Rolf Billeskov, Esterlina V Tan, Marjorie Cang, Rodolfo M Abalos, Jasmin Burgos, Bo Vestergaard Pedersen, Dennis Christensen, Else Marie Agger, Peter Andersen   +8 more
doaj   +1 more source

Comparison of CAF01 with other adjuvants.

, 2013
C57BL/6 mice (n = 4) were immunized three times with 100 µg of OVA in CAF01, Al(OH)3, Montanide, MPL, CFA/2×IFA boosting with a two-week interval. A) Three weeks after the last immunization, the number of OVA-specific cells was assessed by IFN-γ ELISPOT.
Kerstin Werninghaus (104676), Roland Lang (77155), Jon Hansen (16978), Michael Theisen (81720), Claus Aagaard (263500), Dennis Christensen (104693), Else Marie Agger (104700), Brian S. Vandahl (376819), Peter Andersen (88335), Frank Follmann (248464), Ida Rosenkrands (299547), Carsten Kirschning (104698), Karima Brahimi (376818)   +12 more
core   +1 more source