Results 41 to 50 of about 1,231 (164)

A liposome-based mycobacterial vaccine induces potent adult and neonatal multifunctional T cells through the exquisite targeting of dendritic cells. [PDF]

PLoS ONE, 2009
BACKGROUND: In the search for more potent and safer tuberculosis vaccines, CAF01 was identified as a remarkable formulation. Based on cationic liposomes and including a synthetic mycobacterial glycolipid as TLR-independent immunomodulator, it induces ...
Arun T Kamath, Anne-Françoise Rochat, Dennis Christensen, Else Marie Agger, Peter Andersen, Paul-Henri Lambert, Claire-Anne Siegrist   +6 more
doaj   +1 more source

Mitochondrial transfer from cancer-associated fibroblasts increases migration in aggressive breast cancer. [PDF]

J Cell Sci, 2023
Cancer-associated fibroblasts (CAFs) have distinct roles within the tumor microenvironment, which can impact the mode and efficacy of tumor cell migration.
Goliwas KF, Libring S, Berestesky E, Gholizadeh S, Schwager SC, Frost AR, Gaborski TR, Zhang J, Reinhart-King CA.   +8 more
europepmc   +3 more sources

Bacterial outer membrane vesicles and vaccine applications [PDF]

, 2014
Vaccines based on outer membrane vesicles (OMV) were developed more than 20 years ago against Neisseria meningitidis serogroup B. These nano-sized structures exhibit remarkable potential for immunomodulation of immune responses and delivery of “self ...
Acevedo, Reinaldo, Acosta, Armando, Campa, Concepcion, Cardoso, Daniel, Fernandez, Sonsire, Ferro, Valerie, Garcia, Luis, Perez, Jose Luis, Rosenqvist, Einar, Sarmiento, Maria Elena, Zayas, Caridad   +10 more
core   +2 more sources

TBVAC2020 : advancing tuberculosis vaccines from discovery to clinical development [PDF]

, 2017
TBVAC2020 is a research project supported by the Horizon 2020 program of the European Commission (EC). It aims at the discovery and development of novel tuberculosis (TB) vaccines from preclinical research projects to early clinical assessment.
Aagaard, Claus, Andersen, Peter, Bastian, Max, Britton, Warwick, Brosch, Roland, Caccamo, Nadia, Charneau, Pierre, Cho, Sang Nae, Christensen, Dennis, Counoupas, Claudio, Dockrell, Hazel M., Drager, Nick, Gilleron, Martine, Goletti, Delia, Gordon, Stephen, Grooten, Johan, Guilhot, Christophe, Ho, Mei Mei, Huygen, Kris, Inchauspe, Genevieve, Kallert, Stephanie, Kaufmann, Stefan H. E., Lee, Hyejon, Lindenstrom, Thomas, Locht, Camille, Maertzdorf, Jeroen, Marie-Ange Demoitie, Demoitie, Mascart, Francoise, McShane, Helen, Neyrolles, Olivier, Nieuwenhuizen, Natalie, Nisini, Roberto, Ottenhoff, Tom H. M., Patel, Brij, Peixoto, Antonio, Perrie, Yvonne, Romano, Marta, Roordink, Danielle, Ruhwald, Morten, Shin, Sung Jae, Spertini, François, Stenger, Steffen, TBVAC2020 Consortium, Theung Long, Stephane Leung, Thole, Jelle, Tima, Hermann Giresse, Triccas, Jamie, Vergne, Isabelle, Verreck, Frank A. W., Weiner, January, Williams, Ann   +50 more
core   +5 more sources

Heterologous Prime-Boost Combinations Highlight the Crucial Role of Adjuvant in Priming the Immune System

Frontiers in Immunology, 2018
The induction and modulation of the immune response to vaccination can be rationally designed by combining different vaccine formulations for priming and boosting.
Annalisa Ciabattini, Elena Pettini, Fabio Fiorino, Simone Lucchesi, Gabiria Pastore, Jlenia Brunetti, Francesco Santoro, Peter Andersen, Luisa Bracci, Gianni Pozzi, Donata Medaglini   +10 more
doaj   +1 more source

Computational Analysis of Multiparametric Flow Cytometric Data to Dissect B Cell Subsets in Vaccine Studies

Cytometry Part A, Volume 97, Issue 3, Page 259-267, March 2020., 2020
The generation of the B cell response upon vaccination is characterized by the induction of different functional and phenotypic subpopulations and is strongly dependent on the vaccine formulation, including the adjuvant used. Here, we have profiled the different B cell subsets elicited upon vaccination, using machine learning methods for interpreting ...
Simone Lucchesi, Emanuele Nolfi, Elena Pettini, Gabiria Pastore, Fabio Fiorino, Gianni Pozzi, Donata Medaglini, Annalisa Ciabattini   +7 more
wiley   +1 more source

Differential Immunogenicity and Protective Efficacy Elicited by MTO‐ and DMT‐Adjuvanted CMFO Subunit Vaccines against Mycobacterium tuberculosis Infection

Journal of Immunology Research, Volume 2020, Issue 1, 2020., 2020
Tuberculosis (TB) remains a major and global problem of public health. An effective TB subunit vaccine is urgently needed. Proper selection of the delivery system for the vaccine is crucial for inducing an appropriate immune response tailored to control the target pathogen.
Nadeem Ullah, Ling Hao, Yaqi Wu, Yandi Zhang, Qing Lei, Jo-Lewis Banga Ndzouboukou, Xiaosong Lin, Xionglin Fan, Massimo Ralli   +8 more
wiley   +1 more source

Subunit vaccine H56/CAF01 induces a population of circulating CD4 T cells that traffic into the Mycobacterium tuberculosis-infected lung [PDF]

Mucosal Immunology, 2017
The capacity of CD4 T cells to protect against Mycobacterium tuberculosis (Mtb) is governed by their ability to localize to the lung site of infection. Subunit vaccine H56/CAF01, a liposome-adjuvanted fusion protein of Mtb antigens Ag85B, ESAT-6, and Rv2660, conferred durable protection and elicited polyfunctional CD4 T cells that preferentially ...
Woodworth, J.S., Cohen, S.B., Moguche, A.O., Plumlee, C.R., Agger, E.M., Urdahl, K.B., Andersen, P.   +6 more
openaire   +2 more sources

Immune Responses to Pandemic H1N1 Influenza Virus Infection in Pigs Vaccinated with a Conserved Hemagglutinin HA1 Peptide Adjuvanted with CAF®01 or CDA/αGalCerMPEG [PDF]

Vaccines, 2021
This study aimed to evaluate the immune response and protection correlates against influenza virus (IV) infection in pigs vaccinated with the novel NG34 HA1 vaccine candidate adjuvanted with either CAF®01 or CDA/αGalCerMPEG (αGCM). Two groups of six pigs each were vaccinated intramuscularly twice with either NG34 + CAF®01 or NG34 + CDA/αGCM.
Sergi López-Serrano, Lorena Cordoba, Mónica Pérez-Maillo, Patricia Pleguezuelos, Edmond J. Remarque, Thomas Ebensen, Carlos A. Guzmán, Dennis Christensen, Joaquim Segalés, Ayub Darji   +9 more
openaire   +7 more sources

Mucosal delivery of tuberculosis vaccines: a review of current approaches and challenges. [PDF]

, 2019
Introduction: Tuberculosis (TB) remains a major health threat and it is now clear that the current vaccine, BCG, is unable to arrest the global TB epidemic. A new vaccine is needed to either replace or boost BCG so that a better level of protection could
Barclay WR, Elena Stylianou, Helen McShane, Matthew J. Paul, Rajko Reljic, Resende Co T, Rodriguez A, Uranga S, Wong EA   +8 more
core   +1 more source