Results 41 to 50 of about 818 (145)
Frontiers in Immunology, 2019 Most microbes invading through mucosal surfaces cause disease and therefore strategies to induce mucosal immune responses are strongly needed. Vitamin A metabolites, such as retinoic acid (RA), play crucial roles in programming T and B cells to home to ...
Antonella Riccomi +5 more
doaj +1 more source
CD4 and CD8 T cell responses to the M. tuberculosis Ag85B-TB10.4 promoted by adjuvanted subunit, adenovector or heterologous prime boost vaccination. [PDF]
PLoS ONE, 2009 BackgroundAlthough CD4 T cells are crucial for defense against M.tb, it is still not clear whether the optimal response against M.tb in fact involves both CD4 and CD8 T cells.
Tara Elvang +7 more
doaj +1 more source
Journal of Immunology Research, Volume 2018, Issue 1, 2018., 2018 Induction of a robust and long‐lived mucosal immune response during vaccination is critical to achieve protection against numerous pathogens. However, traditional injected vaccines are generally poor inducers of mucosal immunity. One of the effective strategies to improve vaccine efficacy is incorporation of adjuvant molecules that enhance and polarize
Alina S. Dzharullaeva +11 more
wiley +1 more source
The Immunoregulation of Th17 in Host against Intracellular Bacterial Infection
Mediators of Inflammation, Volume 2018, Issue 1, 2018., 2018 T helper 17 cells (Th17) constitute a distinct subset of helper T cells with a unique transcriptional profile (STAT3, RORγ, and RORα), cytokine production pattern (IL17 family), and requirement of specific cytokines for their differentiation (TGF‐β, IL6, IL21, and IL23). Recent studies involving experimental animals and humans have shown that Th17/IL17
Yonghong Li +12 more
wiley +1 more source
Targeting of Ag85B-ESAT-6 and CAF01 in neonatal and adult DC of the draining LN.
, 2013 Twenty-four hours after immunization, (A) the percentage of CAF01-NBD+ CD11c+ cells compared to all cells bearing the adjuvant in the draining LN was determined. In a representative dot plot of an adult mouse, the percent of cells in quadrants is shown. (
Dennis Christensen (104693) +6 more
core +1 more source
Frontiers in Immunology, 2018 Neonates and infants are more vulnerable to infections and show reduced responses to vaccination. Consequently, repeated immunizations are required to induce protection and early life vaccines against major pathogens such as influenza are yet unavailable.
Maria Vono +13 more
doaj +1 more source
EBioMedicine, 2018 Despite inducing strong T cell responses, Mycobacterium tuberculosis (Mtb) infection fails to elicit protective immune memory. As such latently infected or successfully treated Tuberculosis (TB) patients are not protected against recurrent disease. Here,
Thomas Lindenstrøm +5 more
doaj +1 more source
Vaccine Adjuvants Differentially Affect Kinetics of Antibody and Germinal Center Responses
Frontiers in Immunology, 2020 Aluminum salts and squalene based oil-in-water emulsions (SE) are widely used adjuvants in licensed vaccines, yet their mechanisms are not fully known.
Gabriel Kristian Pedersen +4 more
doaj +1 more source
Mucosal Vaccine Development Based on Liposome Technology
Journal of Immunology Research, Volume 2016, Issue 1, 2016., 2016 Immune protection against infectious diseases is most effective if located at the portal of entry of the pathogen. Hence, there is an increasing demand for vaccine formulations that can induce strong protective immunity following oral, respiratory, or genital tract administration.
Valentina Bernasconi +5 more
wiley +1 more source
Immunization in the presence or absence of CAF01.
, 2013 (A) End-point binding titer of rabbits immunized with ITM1_4, in the presence (filled triangles) or absence (open triangles) of CAF01 respectively. Results are given for weeks 8, 12 and 14. Each dot represents one rabbit.
Guillaume Stewart-Jones (452778) +14 more
core +1 more source