Results 31 to 40 of about 4,028 (164)

Occurrence, Serotypes and Virulence Characteristics of Shiga-Toxin-Producing Escherichia coli Isolates from Goats on Communal Rangeland in South Africa

Toxins, 2022
Shiga-toxin-producing Escherichia coli is a foodborne pathogen commonly associated with human disease characterized by mild or bloody diarrhea hemorrhagic colitis and hemolytic uremic syndrome.
Mogaugedi N. Malahlela, Beniamino T. Cenci-Goga, Munyaradzi C. Marufu, Thierry Y. Fonkui, Luca Grispoldi, Eric Etter, Alan Kalake, Musafiri Karama   +7 more
doaj   +1 more source

Synthesis, X‐Ray Analysis, Anticancer Activity, Computational, and in Silico Studies of New Thiophene Pyrazole Conjugates

ChemistryOpen, Volume 15, Issue 6, June 2026.
Two new thiophene–pyrazole derivatives, 8a and 8b, were synthesized from thiophene 3 precursor and fully characterized. The structure of 8a was confirmed by single‐crystal X‐ray diffraction, which revealed a nonplanar conformation stabilized by NH···O hydrogen bonding and weak intermolecular contacts.
Abdullatif Bin Muhsinah, Nabila A. Kheder, Ismail A. Elhaty, Yahia N. Mabkhot   +3 more
wiley   +1 more source

برآورد تابع تقاضای پویای مخارج دفاعی (مورد مطالعه: کشورهای سند چشم‌انداز 1404) [PDF]

فصلنامه سیاست‌های راهبردی و کلان, 2019
حساسیت منطقه خاورمیانه و وجود مناقشات همیشگی در آن، سبب شده است سهم قابل توجهی از تولید ناخالص داخلی کشورهای این منطقه، به‌ بخش دفاعی اختصاص داده شود. بر این اساس، هدف اصلی مقاله حاضر، برآورد تابع تقاضای مخارج دفاعی در 13 کشور خاورمیانه در سال‌های 2014 ...
ابوالقاسم گل خندان
doaj   +1 more source

Ampelopsis Grossedentata Flavonoids Alleviate Hepatic Damage Through Remodeling Intestinal Microflora and Reducing Oxidative Stress in Rats

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
This graphical abstract illustrates the multi‐target antioxidant and anti‐inflammatory effects of AGF in alleviating liver injury, and their association with gut microbiota modulation and enrichment of beneficial microbes. ABSTRACT To investigate the antioxidant effects and underlying mechanisms of Ampelopsis grossedentata flavonoids (AGF) in rats fed ...
Hao Shi, Bo Zhou, Jing Wang, Li Lan Lei
wiley   +1 more source

Drug Delivery Systems for Resiquimod to Control Myeloid‐Derived Suppressor Cells in Cancer Immunotherapy

WIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 2, March/April 2026.
Myeloid‐derived suppressor cells (MDSCs) are key contributors to cancer immunotherapy failure and major targets in new therapeutic strategies. We highlight therapeutic approaches to counteract their immunosuppressive functions and discuss recent efforts to optimize drug delivery for controlling MDSCs, focusing on resiquimod as a representative drug ...
Yanying He, Yoon Yeo
wiley   +1 more source

The effect of catecholamine infusions on myocardial blood flow, metabolic heat production and on general haemodynamics, before and after alprenolol (H56/28), in anaesthetized cats [PDF]

British Journal of Pharmacology, 1970
Summary . In cats anaesthetized with pentobarbitone sodium, infusions of adrenaline, noradrenaline (0·5 μg/kg per min) and isoprenaline (0·25 μg/kg per min) increased myocardial blood flow, myocardial heat production, left ventricular systolic and end‐diastolic pressures, left ventricular +ve and –ve dp/dt max, and calculated cardiac output, effort and
J R, Parratt, R M, Wadsworth
openaire   +2 more sources

Modulation of primary immune response by different vaccine adjuvants

Frontiers in Immunology, 2016
Adjuvants contribute to enhancing and shaping the vaccine immune response through different modes of action. Since the primary immune response can influence the overall quality of the response generated, here we investigate early biomarkers of ...
Annalisa Ciabattini, Elena Pettini, Fabio Fiorino, Gabiria Pastore, Peter Andersen, Gianni Pozzi, Donata Medaglini   +6 more
doaj   +1 more source

Higher Genetic Diversity Across Several Small Patches Compared to a Single Large Patch: A Within‐Species Test of SLOSS

Evolutionary Applications, Volume 19, Issue 3, March 2026.
ABSTRACT The SLOSS (Single Large or Several Small) debate is crucial in reserve design, focusing on evaluating the conservation efficacy of a single large reserve versus multiple small reserves for species preservation. While accumulating evidence suggests that multiple small reserves may conserve greater species diversity, the question of how to ...
Fumin Lei, Dandan Li, Hua Zhu, Yuzhu Xia, Xinyi Chen, Jianxiang Yu, Shuiliang Guo, Jing Yu   +7 more
wiley   +1 more source

ESAT-6 (EsxA) and TB10.4 (EsxH) based vaccines for pre- and post-exposure tuberculosis vaccination. [PDF]

PLoS ONE, 2013
The ESX systems from Mycobacterium tuberculosis are responsible for the secretion of highly immunogenic proteins of key importance for bacterial survival and growth. The two prototypic proteins, ESAT-6 (EsxA from ESX-1) and TB10.4 (EsxH from ESX-3) share
Truc Hoang, Claus Aagaard, Jes Dietrich, Joseph P Cassidy, Gregory Dolganov, Gary K Schoolnik, Carina Vingsbo Lundberg, Else Marie Agger, Peter Andersen   +8 more
doaj   +1 more source

Balanced Expression of the Diiron Oxygenase BioE Is Essential for Biotin Homeostasis in Elizabethkingia meningoseptica

Advanced Science, Volume 13, Issue 10, 18 February 2026.
BioE is a new diiron oxygenase that catalyzes the conversion of long‐chain acyl groups into pimeloyl thioester, initiating biotin synthesis. The overexpression of EmBioE disrupts lipid metabolic homeostasis, requiring repressor BioL to maintain a balance between long‐chain fatty acids and biotin synthesis.
Meng Zhang, Ying‐ying Fu, Xiaoqiang Yang, Qiuying Qin, Xinyu Su, Jiaming Fang, Yanhua Kang, Qingwen He, Zhi Ruan, Yongchang Xu   +9 more
wiley   +1 more source