Results 121 to 130 of about 32,113 (291)

Deferoxamine therapy for intracerebral hemorrhage: A systematic review

PLoS ONE, 2018
Intracerebral hemorrhage (ICH) is a significant cause of morbidity and mortality worldwide. Several recent controlled trials have reported that deferoxamine (DFX) therapy appears to be effective for ICH.
Liling Zeng, Li-Rong Tan, Haijun Li, Qixin Zhang, Yongxian Li, Jianwen Guo   +5 more
semanticscholar   +1 more source

Insights Into Macrophage Ferroptosis: Implications for Atherosclerosis

Cell Proliferation, EarlyView.
Macrophage ferroptosis drives atherosclerosis by enhancing oxidative stress and inflammation, accelerating plaque progression and instability. Targeting macrophage ferroptosis presents a promising therapeutic strategy for atherosclerosis treatment.
Xiehui Chen, Xiangbo Liu, Changchun Zeng
wiley   +1 more source

Coenzyme A mitigates cystine‐deprivation‐induced ferroptosis by suppressing the iron‐starvation response

The FEBS Journal, EarlyView.
Cystine (Cys2) deprivation in pancreatic cancer cells induces oxidative stress that destabilizes cytosolic iron–sulfur cluster (ISC) proteins, triggering an iron‐regulatory protein (IRP)‐mediated iron‐starvation response (ISR). This leads to increased iron uptake (via TFRC), an expanded labile iron pool, and ferroptosis.
Mingjun Tan, Yunzhan Li, Lei Sang, Min Wang, Qin Li, Zekun Li, Dongxiao Sun, Xiuchao Wang, Shengyu Yang   +8 more
wiley   +1 more source

A combination of Deferoxamine mesylate and minimally invasive surgery with hematoma lysis for evacuation of intracerebral hemorrhage

Journal of Cerebral Blood Flow and Metabolism, 2019
Intracerebral hemorrhage is associated with significant morbidity and mortality. Some clinical trials demonstrated a trend towards benefit with surgical evacuation of intracerebral hemorrhage, without strong statistically significant results.
A. Pandey, B. Daou, N. Chaudhary, G. Xi
semanticscholar   +1 more source

Is Ferroptosis the Mechanistic Bridge Connecting Iron Dysregulation to Muscle Wasting and Functional Decline in Aging?

Aging Cell, Volume 25, Issue 2, February 2026.
This work proposes ferroptosis as a mechanistic driver of age‐related muscle dysfunction, whereby iron dyshomeostasis and impaired antioxidant capacity promote lipid peroxidation, and eventually trigger ferroptosis, leading to muscle wasting, and ultimately contributing to weakness and functional decline with aging.
Rola S. Zeidan, Simon Reinhard, Anna Picca, Emanuele Marzetti, Christiaan Leeuwenburgh, James F. Collins, Stephen D. Anton   +6 more
wiley   +1 more source

Pulmonary Mucormycosis in a patient with Acute Myeloid Leukemia [PDF]

, 2015
Introduction Mucormycosis is a rare fungal infection that is common amongst uncontrolled diabetics and immunocompromised patients. The most common clinical presentation is rhino-orbital-cerebral infection, which typically affects diabetics with ...
Diemer, MD, Gretchen, Kasner, MD, Margaret, Pan, MD, Jonathan, Patel, MD, Sheel   +3 more
core   +2 more sources

Iron Overload Mediates the Differential Cell Fate of Astrocytes from Neurons and Its Regulatory Mechanisms in Ischemic Stroke

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Upon ischemia/reperfusion‐induced iron overload condition, neurons and astrocytes exhibit similar oxidative stress changes but opposite alterations in endogenous antioxidant defense mechanisms, leading to divergent ferroptotic outcomes. The iron deposition and neuronal loss are increased within the perilesional cortex of stroke patients ...
Yi Guo, Yue Wang, Yong Ni, Bin Bo, Jinzhi He, Yongming Zhu, Aiping Qin, Xianyong Zhou, Huaping Du, Yuan Liu, Tianyao Wang, Yudu Li, Yibo Zhao, Zengai Chen, Zhipei Liang, Yao Li, Yuan Xu, Huiling Zhang   +17 more
wiley   +1 more source

Anemia From Inflammation After Intracerebral Hemorrhage and Relationships With Outcome

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Baseline anemia is associated with poor intracerebral hemorrhage (ICH) outcomes. However, underlying drivers for anemia and whether anemia development after ICH impacts clinical outcomes are unknown.
David J. Roh, Fernanda Carvalho Poyraz, Eric Mao, Qi Shen, Vedant Kansara, Azzurra Cottarelli, Sandy Song, Travis Nemkov, Aditya Kumar, Krystalyn E. Hudson, Shivani Ghoshal, Soojin Park, Sachin Agarwal, Edward Sander Connolly, Jan Claassen, Lisa Baumann Kreuziger, Eldad Hod, Sharon Yeatts, Lydia D. Foster, Magdy Selim   +19 more
doaj   +1 more source

Ferritin level prospectively predicts hepatocarcinogenesis in patients with chronic hepatitis B virus infection [PDF]

, 2018
Previous studies have detected a higher level of ferritin in patients with hepatocellular carcinoma (HCC), but a potential causal association between serum ferritin level and hepatocarcinogenesis remains to be clarified.
Bian, Zhenyuan, Fang, Wan, Hann, Hie-Won, Tao, Kaishan, Wan, Shaogui, Wang, Chun, Wang, Yang, Ye, Zhong, Yin, Chun   +8 more
core   +1 more source

Deferoxamine ameliorates adipocyte dysfunction by modulating iron metabolism in ob/ob mice

Endocrine Connections, 2018
Objective The mechanisms underlying obesity and anti-obesity processes have garnered remarkable attention as potential therapeutic targets for obesity-associated metabolic syndromes.
Hong-Fa Yan, Zhao-Yu Liu, Zhi-Ang Guan, Chuang Guo   +3 more
semanticscholar   +1 more source