Results 101 to 110 of about 16,909 (214)

Anemia From Inflammation After Intracerebral Hemorrhage and Relationships With Outcome

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Baseline anemia is associated with poor intracerebral hemorrhage (ICH) outcomes. However, underlying drivers for anemia and whether anemia development after ICH impacts clinical outcomes are unknown.
David J. Roh, Fernanda Carvalho Poyraz, Eric Mao, Qi Shen, Vedant Kansara, Azzurra Cottarelli, Sandy Song, Travis Nemkov, Aditya Kumar, Krystalyn E. Hudson, Shivani Ghoshal, Soojin Park, Sachin Agarwal, Edward Sander Connolly, Jan Claassen, Lisa Baumann Kreuziger, Eldad Hod, Sharon Yeatts, Lydia D. Foster, Magdy Selim   +19 more
doaj   +1 more source

Coenzyme A mitigates cystine‐deprivation‐induced ferroptosis by suppressing the iron‐starvation response

The FEBS Journal, Volume 293, Issue 11, Page 3288-3302, June 2026.
Cystine (Cys2) deprivation in pancreatic cancer cells induces oxidative stress that destabilizes cytosolic iron–sulfur cluster (ISC) proteins, triggering an iron‐regulatory protein (IRP)‐mediated iron‐starvation response (ISR). This leads to increased iron uptake (via TFRC), an expanded labile iron pool, and ferroptosis.
Mingjun Tan, Yunzhan Li, Lei Sang, Min Wang, Qin Li, Zekun Li, Dongxiao Sun, Xiuchao Wang, Shengyu Yang   +8 more
wiley   +1 more source

In vivo effects of curcumin and deferoxamine in experimental endometriosis

, 2017
Background. Endometriosis is one of the most common chronic gynecological diseases. Objectives. The aim of the study was to examine the effects of curcumin and/or deferoxamine on cell proliferation in a rat model of endometriosis.
Uz, Yesim Hulya, Kizilay, Gulnur, Yilmaz, Ali, Kayisli, Umit Ali, Ulucam, Enis, Cukur, Ziya, Seren, Gulay   +6 more
core   +1 more source

HIV Tat‐Stimulated Microglial Extracellular Vesicles Are Enriched for Ferroptosis Mediators: Role of Dysregulated Autophagy [PDF]

J Extracell Biol
ABSTRACT Extracellular vesicles (EVs) serve as conduits for intercellular communication, under both physiological and pathological contexts. During disease pathogenesis, microglia‐derived EVs (MEVs) play a key role in transferring pathological cargo to the recipient cells, thereby modulating their phenotype and function.
Singh S, Horanieh E, Semerad C, Periyasamy P, Sil S, Buch S.   +5 more
europepmc   +2 more sources

Coronary venous retroinfusion of deferoxamine reduces infarct size in pigs

, 1991
The efficacy of coronary venous retroinfusion of the iron chelator deferoxamine was studied in 24 pentobarbital-anesthetized open chest pigs with a 60 min occlusion of the left anterior descending coronary artery followed by 3 h of reperfusion.
Nordlander, Rolf, Kobayashi, Shiro, Haendchen, Roberto V., Wakida, Yasushi, Kar, Sheila, Tadokoro, Hiroyuki, Corday, Eliot   +6 more
core   +1 more source

Ocular complications in thalassemia major patients treated with deferoxamine: a hospital-based, cross-sectional study [PDF]

Health Science Monitor
Background & Aims: β-thalassemia is a severe hereditary disorder caused by defective globin synthesis. Patients suffering from β-thalassemia major require regular blood transfusion therapy to survive.
Naser Samadi Aidenloo, Qader Motarjemizadeh, Sina Hasani Shayan   +2 more
doaj  

Redox Disruption Induced by Saquayamycin B1 Promotes Cytotoxicity in Resistant Melanoma Cells

ChemMedChem, Volume 21, Issue 10, 27 May 2026.
Saquayamycin B1 (SQ‐B1), an antibiotic isolated from Streptomyces sp. I072, triggers cell death in different melanoma cell lines, including chemoresistant SK‐MEL‐5. SQ‐B1 elevates O2•‐ and NO• on both sides of the membrane and blocks glutathione transferase (GSTP‐1) and glutathione reductase (GSR), destabilizing the GSH/GSSG antioxidant system.
Geovana Guedes Silvestre, Thalisson Amorim de Souza, Alan Ferreira Alves, Valeria Dutan‐Patiño, Jean‐Michel Huvelin, Mathilde Gourdel, Mikael Croyal, Samuel Cibulski, Demetrius Antonio Machado de Araújo, Marcus Tullius Scotti, Josean Fechine Tavares, Angela Tesse, El‐Hassan Nazih, Marianna Vieira Sobral   +13 more
wiley   +1 more source

The effect of intravenous Deferoxamine during blood transfusion time in thalassemia major patients [PDF]

CONTEXT AND OBJCTIVE: Subcutaneous Deferoxamine intolerance by patients and reject its use Cause to iron overload and its complications. So, uses other methods with easier tolerate and reduce Deferoxamine consumption is necessary.
فتحی, افشین, امانی, فیروز   +1 more
core  

Comparative Efficacy of Deferiprone, Deferoxamine and Combination of Deferiprone and Deferoxamine on Serum Ferritin Value in Beta-Thalassemia Patients [PDF]

, 2015
Background: Iron overload is a predictable and lifethreatening complication in patients with thalassemia. Effective and convenient iron chelation remains one of the main targets of clinical management of thalassemia major.
Haniye Mohsenkhah Amlashi, Amlashi, H.M., Nargesbeygom Mirbehbahani, Mirbehbahani, N., Jahazi, A., Behnampour, N., Azam Jahazi, Naser Behnampour   +7 more
core   +1 more source

Deferoxamine Treatment Effectively Prevents Periodontitis Progression by Reducing Inflammation and Osteoclastogenesis in Experimental Periodontitis Rats

Journal of Inflammation Research
Yanlin Zhu,1,2 Shuwei Qiao,2,3 Yuxuan Pang,2,3 Huimin Wang,2,3 Yanmin Zhou1,2 1Department of Dental Implantology, Hospital of Stomatology, Jilin University, Changchun, People’s Republic of China; 2Jilin Provincial Key Laboratory of Tooth Development and ...
Zhu Y, Qiao S, Pang Y, Wang H, Zhou Y
doaj