Results 101 to 110 of about 18,326 (214)

Metformin Inhibits Ferroptotic Cell Death by Suppressing Cysteine Deprivation‐Induced Mitochondrial Dysfunction

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT Ferroptosis, an iron‐dependent form of regulated cell death driven by excessive lipid peroxidation, has emerged as a promising therapeutic strategy for cancer. Metformin, a widely used biguanide antidiabetic drug, has recently been reported to induce ferroptosis and exert anticancer effects in various malignancies.
Se‐Kyeong Jang, Selim Kim, Gyeongmi Kim, Jungil Hong, In‐Chul Park, Hyeon‐Ok Jin   +5 more
wiley   +1 more source

Mixed Invasive Aspergillus–Mucorales Pulmonary Coinfection in a Diabetic Patient: An Uncommon Dual Fungal Pneumonia and Literature Review

Respirology Case Reports, Volume 14, Issue 10, October 2026.
Our case describes a rare lung co‐infection caused by Aspergillus and Mucorales in a 61‐year‐old man with uncontrolled diabetes and chronic kidney disease. The diagnosis was made by BAL PCR and biopsy. Despite antifungal treatment, the patient worsened and died.
Vinay Venugopal, Saurabh Karmakar, Abdul Raouf Wani, Akshita Gupta, Gaurav Kumar Singh, Vijay Kumar, Shubhendu Mishra, Alpana Srivastava   +7 more
wiley   +1 more source

Modulation of inflammatory response after spinal cord trauma with deferoxamine, an iron chelator.

, 2010
The standard iron-chelator deferoxamine is known to reduce neurological deficits. The aim of the present study was to evaluate the contribution of deferoxamine in the secondary damage in experimental spinal cord injury (SCI) in mice, induced by the ...
PATERNITI, IRENE, CUZZOCREA, Salvatore, BRAMANTI, Placido, Emanuela E, Mazzon E, Galuppo M, Paola RD   +6 more
core   +1 more source

Ocular complications in thalassemia major patients treated with deferoxamine: a hospital-based, cross-sectional study [PDF]

Health Science Monitor
Background & Aims: β-thalassemia is a severe hereditary disorder caused by defective globin synthesis. Patients suffering from β-thalassemia major require regular blood transfusion therapy to survive.
Naser Samadi Aidenloo, Qader Motarjemizadeh, Sina Hasani Shayan   +2 more
doaj  

Peroxiredoxin 4 Involved in Spermatogenesis by Affecting Oxidative Stress and Ferroptosis

Andrology, Volume 14, Issue 7, Page 2329-2346, October 2026.
ABSTRACT Background The main functions of testes are sperm production and androgen secretion in testicular befitting microenvironment. Excessive level of the reactive oxygen species (ROS) from metabolism and cellular events can lead to oxidative stress (OS) and ferroptosis, which injure the functions of mitochondria and endoplasmic reticulum (ER) of ...
Shuning Yuan, Nini Wei, Weiwei Ma, Mengting Hu, Bei Zhang, Li Gao, Chao Gao, Xiaoyu Yang, Yan Meng, Jiayin Liu, Yugui Cui   +10 more
wiley   +1 more source

Chelator-facilitated removal of iron from transferrin: Relevance to combined chelation therapy [PDF]

, 2008
Current iron chelation therapy consists primarily of DFO (desferrioxamine), which has to be administered via intravenous infusion, together with deferiprone and deferasirox, which are orally-active chelators.
Evans, PJ, Evans, RW, Hider, RC, Devanur, LD   +3 more
core  

Optimal Hypoxia Mimetic Small Molecules for Enhancing Angiogenic Properties of Stem Cells From Human Exfoliated Deciduous Teeth

International Endodontic Journal, Volume 59, Issue 10, Page 2122-2142, October 2026.
ABSTRACT Aim Hypoxic preconditioning of cells holds promise for regenerative therapies, yet identifying effective and safe methods for clinical application remains challenging. We aimed to determine optimal hypoxia‐mimetic small molecules (SMs) that stabilize hypoxia‐inducible factor‐1α (HIF‐1α) and their dosages for hypoxic preconditioning in stem ...
Hong Wang, Jiawei Liu, Xintao Yang, Mohamad Koohi‐Moghadam, Shuting Gao, Yuanyuan Han, Dineshi Sewvandi Thalakiriyawa, James Kit Hon Tsoi, Yanqi Yang, Waruna Lakmal Dissanayaka   +9 more
wiley   +1 more source

Association Between Sleep Quality and Oxidative Stress in Postoperative Cardiovascular Patients—A Pilot Study

Journal of Sleep Research, Volume 35, Issue 5, October 2026.
In 15 postoperative cardiac surgery patients, venous reactive oxygen species (ROS) measured by electron spin resonance (ESR) over 48 h showed no consistent circadian pattern. Higher ROS was associated with lower subjective sleep efficiency and more nocturnal awakenings, but not with other sleep measures.
K. Krawczyk, D. Riemann, E. Schleicher, A. Günther, A. Ayekoi, M. Czerny, J. S. Pooth, T. Böhmerle, B. Feige, J. Sahlmann, F. Beyersdorf   +10 more
wiley   +1 more source

Evaluating Effectiveness of Deferasirox Versus Deferoxamine in Improving Clinical Outcomes among Patients with Transfusion-Dependent Thalassemia: A Randomized Controlled Trial

Link Medical Journal of Health and Community Research
Background: Transfusion-dependent β-thalassemia necessitates lifelong blood transfusions that progressively accumulate systemic iron, causing cardiomyopathy, hepatic cirrhosis, and endocrine failure without effective chelation. Deferasirox, a once-daily
Muhammad Mohsin Shoukat, Hafiza Khadija Tariq, Fareed Ullah, Muhammad Arslan Liaqat, Areeba Sajjad, Nauman Akhtar   +5 more
doaj   +1 more source

Intra-ventricular delivery of the iron chelator deferoxamine provides protection in R6/2 HD mice.

, 2013
Deferoxamine was delivered into the left ventricle of 6-week-old R6/2 HD mice at a dose-rate of 1-nmole / hour. Mice were analyzed daily before and after surgery for Rota-rod performance. A.
Linh Q. Lam (469736), Steven Hersch (273506), Zhaojie Zhang (403317), Barry Lai (34704), Irene Volitakis (31156), Jianfang Chen (469733), Ashley I. Bush (31161), Jonathan H. Fox (273480), James A. Duce (469735), Eileen Marks (469734)   +9 more
core   +1 more source