A label-free fluorescent probe for deferiprone quantification in exhaled breath condensate utilizing UiO-66 MOF/ferric ions system [PDF]
Scientific ReportsThis study developed a simple and label-free fluorescent probe for deferiprone quantification in exhaled breath condensate (EBC) samples. For that, UiO-66, synthesized in a one-step process with the solvothermal method, along with ferric ions, provided a
Nima Sheikh Abdollahzadeh Mamaghani +5 more
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Antiplatelet activity of deferiprone through cyclooxygenase-1 inhibition
Platelets, 2020 Thalassemia patients are susceptible to both iron overload and thromboembolism. Deferiprone is an iron chelator that shows an antiplatelet activity and thus may alleviate platelet hyperactivation in thalassemia.
Ngan Thi Tran +4 more
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Efficacy and Side Effects of Deferasirox and Deferiprone for Thalasemia Major in Children [PDF]
Pharmacology and Clinical Pharmacy Research, 2016 Thalassemia major (TM) is an inherited disease caused by defective or absent of hemoglobin chain synthesis. Regular chelation therapy is necessary to reduce excess iron in several organs of TM patients.
Asti Y. Rindarwati +2 more
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Rationally designed copper–deferiprone–phenanthroline complex as a dual anticancer and SARS-CoV-2 inhibitor [PDF]
RSC AdvancesA novel ternary copper–deferiprone–phenanthroline complex was rationally designed, synthesized, and thoroughly characterized. DNA interaction studies revealed that deferiprone binds to CT-DNA via groove binding, whereas the copper complex predominantly ...
Zeinab Mirzaei-Kalar +5 more
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Interactions of Salicyluric Acid with Metal Ions and Ascorbic Acid: Possible Biological and Toxicity Implications in Aspirin Use [PDF]
BiologyAspirin is one of the most widely used pharmaceuticals, yet its long-term use is associated with some side effects, including iron-deficiency anemia, which has been mainly linked to the iron-chelating properties of its major metabolite, salicyluric acid (
Viktor A. Timoshnikov +4 more
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Fertility and endocrinopathies among adults with β-thalassemia major treated at Dubai thalassemia center [PDF]
Frontiers in EndocrinologyIntroductionβ-thalassemia major (BTM) is made up of group of quantitative anemias characterized by severe anemia and hemochromatosis from frequent blood transfusion.
Rabah Almahmoud +5 more
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Molecules, 2022 The microscale thermophoresis (MST) technique was utilized to investigate lactoferrin–drug interaction with the iron chelator, deferiprone, using label-free system. MST depends on the intrinsic fluorescence of one interacting partner.
Mufarreh Asmari +7 more
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Deferiprone, an iron chelator, alleviates platelet hyperactivity in patients with β-thalassaemia/HbE
Drugs in Context, 2022 Background: Hyperfunctional platelets play important roles in thromboembolism in patients with β-thalassaemia/ haemoglobin E (β-thal/HbE). Our previous study revealed ex vivo inhibitory effects of deferiprone on normal platelets.
Ngan Thi Tran +5 more
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eLife, 2023 Myelodysplastic syndrome (MDS) is a heterogeneous group of bone marrow stem cell disorders characterized by ineffective hematopoiesis and cytopenias, most commonly anemia.
Wenbin An +9 more
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PLoS ONE, 2021 IntroductionAdhesions are often considered to be an inevitable consequence of abdominal and pelvic surgery, jeopardizing the medium and long-term success of these procedures.
Rajan Sundaresan Vediappan +12 more
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