Results 21 to 30 of about 1,534 (92)

Ferroptosis: Newly Emerged Regulator for Human Disease

MedComm, Volume 7, Issue 9, September 2026.
Ferroptosis is a key regulated cell death pathway closely involved in cancers, neurodegenerative disorders, acute organ injuries, and cardiovascular and chronic metabolic diseases, representing a promising therapeutic target for diverse human illnesses.
Dandan Xiao, Lin Ye, Tianqi Jiang, Mengyuan Liu, Yuxia Zhou   +4 more
wiley   +1 more source

The optimization of iron chelation with deferiprone

, 1997
grantor: University of TorontoDeferiprone is an orally active iron-chelating agent that reduces the body iron burden of chronically transfused, iron-overloaded homozygous beta-thalassemia patients.
Fassos, Frank Fotios
core   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, Volume 600, Issue 16, Page 2219-2225, August 2026.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Management of Iron Overload in Infants and Toddlers With Diamond–Blackfan Anemia Syndrome: A French–Italian Study

American Journal of Hematology, Volume 101, Issue 8, Page 1856-1865, August 2026.
ABSTRACT Diamond–Blackfan Anemia Syndrome (DBAS) is a rare congenital anemia often requiring chronic red blood cell transfusions from infancy. Without appropriate chelation, iron overload develops early and may be severe; however, no data are available on chelation in patients under 3 years of age.
Francesca Torchio, Baptiste Lecalvez, Emanuela Garelli, Coralie Mallebranche, Adriana Carando, Marie‐Pierre Castex, Nathalie Garnier, Marco Zecca, Nathalie Aladjidi, Elisa Bertoni, Arthur Sterin, Maria Licciardello, Anne Sirvent, Antonella Sau, Isabelle Marie, Benedicte Bruno, Lydie M. Da Costa, Franca Fagioli, Paola Quarello, Thierry Leblanc   +19 more
wiley   +1 more source

Antiplatelet activity of deferiprone through cyclooxygenase-1 inhibition

, 2019
Thalassemia patients are susceptible to both iron overload and thromboembolism. Deferiprone is an iron chelator that shows an antiplatelet activity and thus may alleviate platelet hyperactivation in thalassemia.
Benjaporn Akkawat (7111757), Ngan Thi Tran (7111754), Ponlapat Rojnuckarin (4693228), Noppawan Phumala Morales (7111760), Rataya Luechapudiporn (7111763)   +4 more
core   +1 more source

Correction of Ineffective Erythropoiesis and Normalization of Iron Homeostasis After Exagamglogene Autotemcel in Transfusion‐Dependent β‐Thalassemia

American Journal of Hematology, Volume 101, Issue 8, Page 1969-1979, August 2026.
ABSTRACT Exagamglogene autotemcel (exa‐cel) is a one‐time, ex vivo, CRISPR‐Cas9 gene edited cell therapy approved for patients with transfusion dependent β‐thalassemia (TDT) aged 12–35 years. In a Phase 3 study (CLIMB THAL‐111), exa‐cel treatment resulted in reactivation of fetal hemoglobin and increases in total hemoglobin, leading to transfusion ...
Sujit Sheth, Selim Corbacioglu, Josu de la Fuente, Mattia Algeri, Joachim Rupprecht, Kevin H. M. Kuo, Ami J. Shah, Peter Lang, Hayley Merkeley, Ben Carpenter, Markus Y. Mapara, Robert I. Liem, Stephan Grupp, Yogi Chopra, Amanda M. Li, Janet L. Kwiatkowski, Melanie Kirby‐Allen, Maria Domenica Cappellini, Antonis Kattamis, Sakellarios Zairis, Tina Liu, William Hobbs, Haydar Frangoul, Franco Locatelli, Roland Meisel, on behalf of the CLIMB THAL‐111 and CLIMB‐131 Study Groups   +25 more
wiley   +1 more source

Sappanwood extract modulates hepatic structure–function in hepatomegaly and hepcidin related iron regulatory pathways in a phenylhydrazine induced hemolytic anemia rat model relevant to thalassemia

Animal Models and Experimental Medicine, Volume 9, Issue 8, Page 1674-1689, August 2026.
Phenylhydrazine (PHZ) induces hemolytic anemia characterized by increased erythrocyte destruction and ineffective erythropoiesis, leading to hepcidin suppression through disruption of the BMP/SMAD signaling pathway. Reduced hepcidin levels enhance intestinal iron absorption and hepatic iron accumulation, leading to hepatic iron overload.
Mohammad Indra Pratama, Ratu Safitri, Desak Made Malini, Mas Rizky A. A. Syamsunarno, Mohammad Ghozali, Madihah Madihah   +5 more
wiley   +1 more source

Prevention of Iron Overload and Long Term Maintenance of Normal Iron Stores in Thalassaemia Major Patients using Deferiprone or Deferiprone Deferoxamine Combination

, 2017
Decrease in mortality and morbidity is observed in thalassaemia major patients with reduced iron load in comparison to heavy iron loaded patients. Effective and complete treatment of transfusional iron overload can be achieved by chelation protocols that
Christina Kontoghiorghe, Annita Kolnagou, George Kontoghiorghes   +2 more
core   +1 more source

Unraveling Neurodegeneration: Common Molecular Mechanisms and Novel Therapeutic Concepts in Major Neurodegenerative Disorders

Brain and Behavior, Volume 16, Issue 8, August 2026.
Neurodegenerative diseases share common pathological mechanisms including chronic neuroinflammation, oxidative stress, mitochondrial dysfunction, and protein aggregation. Despite distinct hallmarks in Alzheimer's, Parkinson's, Huntington's, ALS, and MS, these processes converge, driving progressive neuronal damage and neurodegeneration.
Fatemeh sadat Aldaghi, Zakieh Siahpoosh, Zivar Salehi, Farhad Mashayekhi, Shabnam Sohrabnezhad   +4 more
wiley   +1 more source

Deferiprone inhibits histopathological signs in skin of CKDmice.

, 2015
(A) Histopathological findings in the skin of mice with CKD and CKD mice treated with 125 mg/kg deferiprone for 16 weeks. Representative images are of dorsal skin biopsies of each group at 200X magnification H&E stained sections.
Oleg Karaduta (787139), Judit K. Megyesi (456448), Sudhir V. Shah (787136), Kim M. Hiatt (787137), Chhanda Bose (787135), Kimberly A. Hall (787138), Sundararaman Swaminathan (787140)   +6 more
core   +1 more source