Results 21 to 30 of about 6,396 (177)

Precision Medicine in Neurodegeneration with Brain Iron Accumulation (NBIA) Disorders: An Update on Emerging Treatments. [PDF]

Mov Disord Clin Pract
Abstract Background Neurodegeneration with Brain Iron Accumulation (NBIA) is a heterogeneous group of heritable, mostly recessive, progressive neurodegenerative diseases characterized by iron deposition in the basal ganglia and brainstem. There are no solid global epidemiological data on prevalence and incidence of NBIA subtypes, but registry data and ...
Schneider SA, Garg D, Iankova V, Klopstock T.   +3 more
europepmc   +2 more sources

Sappanwood extract modulates hepatic structure-function in hepatomegaly and hepcidin related iron regulatory pathways in a phenylhydrazine induced hemolytic anemia rat model relevant to thalassemia. [PDF]

Animal Model Exp Med
Phenylhydrazine (PHZ) induces hemolytic anemia characterized by increased erythrocyte destruction and ineffective erythropoiesis, leading to hepcidin suppression through disruption of the BMP/SMAD signaling pathway. Reduced hepcidin levels enhance intestinal iron absorption and hepatic iron accumulation, leading to hepatic iron overload.
Pratama MI, Safitri R, Malini DM, Syamsunarno MRAA, Ghozali M, Madihah M.   +5 more
europepmc   +2 more sources

Contemporary Management of Thalassemia: A Perspective on Current Standards and the Emergence of FDA-Approved Oral Therapy. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Thalassemia is an inherited hemoglobin disorder characterized by ineffective erythropoiesis, chronic anemia, and progressive multisystem complications that require lifelong management. Current treatment relies on regular red blood cell transfusions, iron chelation therapy, and supportive multidisciplinary care, while ...
Zainab F, Hasan AH, Abid MH, Abid MA.
europepmc   +2 more sources

Therapeutic Silencing of Tmprss6 Reduces Iron-Induced Inflammation and Prolongs Survival in MDS Mice. [PDF]

Am J Hematol
ABSTRACT Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic disorders characterized by ineffective hematopoiesis, cytopenias, and an increased risk of progression to acute myeloid leukemia (AML). Despite advances in supportive and targeted therapies, disease‐modifying interventions remain limited.
Vilcassim S, Pholngam N, Thubthed R, Nualkaew T, Svasti S, Chaichompoo P, Kysenius K, Crouch PJ, Dames S, Eisermann M, Martinez A, Schaeper U, Vadolas J, Grigoriadis G.   +13 more
europepmc   +2 more sources

Novel Antidepressant-Like Properties of the Iron Chelator Deferiprone in a Mouse Model of Depression

, 2022
Depressed individuals who carry the short allele for the serotonin-transporter-linked promotor region of the gene are more vulnerable to stress and have reduced response to first-line antidepressants such as selective serotonin reuptake inhibitors. Since
Hale, MW, Aitken, C, Uzungil, V, Tran, H, Bush, AI, Renoir, T, Payet, JM, Wilson, C, Opazo, CM, Li, S, Mawal, CH, Hannan, AJ   +11 more
core   +2 more sources

Solubility and thermodynamic study of deferiprone in propylene glycol and ethanol mixture

BMC Chemistry, 2023
This work aims to obtain the solubility, density and thermodynamic parameters of deferiprone in propylene glycol and ethanol. For this purpose, a shake-flask technique was applied for solid–liquid equilibration and the spectrophotometry method was ...
Samira Radmand, Homa Rezaei, Hongkun Zhao, Elaheh Rahimpour, Abolghasem Jouyban   +4 more
doaj   +1 more source

Measurement and correlation of solubility data for deferiprone in propylene glycol and 2-propanol at different temperatures

Heliyon, 2023
This investigation dealt with the thermodynamic properties, saturated solubility values, and solvation behavior of deferiprone as an oral iron chelator agent in non-aqueous mixtures of propylene glycol and 2-propanol using experimental measurements and ...
Homa Rezaei, Elaheh Rahimpour, Fleming Martinez, Abolghasem Jouyban   +3 more
doaj   +1 more source

Deferasirox, deferiprone and desferrioxamine treatment in thalassemia major patients: cardiac iron and function comparison determined by quantitative magnetic resonance imaging

Haematologica, 2011
Background Oral deferiprone was suggested to be more effective than subcutaneous desferrioxamine for removing heart iron. Oral once-daily chelator deferasirox has recently been made commercially available but its long-term efficacy on cardiac iron and ...
Alessia Pepe, Antonella Meloni, Marcello Capra, Paolo Cianciulli, Luciano Prossomariti, Cristina Malaventura, Maria Caterina Putti, Alma Lippi, Maria Antonietta Romeo, Maria Grazia Bisconte, Aldo Filosa, Vincenzo Caruso, Antonella Quarta, Lorella Pitrolo, Massimiliano Missere, Massimo Midiri, Giuseppe Rossi, Vincenzo Positano, Massimo Lombardi, Aurelio Maggio   +19 more
doaj   +1 more source

Perbedaan Kadar Thyroid Stimulating Hormone dan Free Thyroxine pada Pasien Talasemia Β-Mayor dengan Kelasi Besi Deferasirox dan Deferiprone

Sari Pediatri, 2018
Latar belakang. Talasemia β Mayor merupakan kelainan herediter yang disebabkan gangguan produksi rantai globin. Transfusi rutin menyebabkan kelebihan besi yang tertimbun dalam jaringan sehingga menyebabkan kardiomiopati, gangguan liver, dan komplikasi ...
Aries - Krisbiyantoro, Harsono Salimo, Annang Giri Moelyo   +2 more
doaj   +1 more source

Hematological Parameters in Beta Thalassemia Major Children [PDF]

Minia Journal of Medical Research, 2022
Background: Thalassemia is a hematological disorder that is caused by mutations in the genes that encode hemoglobin chains. Mutations in the β-globin gene are the most common cause of genetic disorders in humans, with 350 β-thalassemia variants ...
Zamzam Mohamed, Doaa Ismail, Samira Sayed, Arwa Aziz   +3 more
doaj   +1 more source