Results 41 to 50 of about 5,736 (192)
Cells, 2020 Deferiprone (DFP), also known as Ferriprox, is an FDA-approved, orally active, iron chelator that is currently used clinically for the treatment of iron-overload, especially in thalassaemia major.
Marco Fiorillo +4 more
doaj +1 more source
Progress of Immunotherapies in Parkinson's Disease
CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.Parkinson's disease (PD) is caused by an immune disorder triggered by α‐synuclein, leading to a persistent neuroinflammatory cycle that drives the disease from non‐motor symptoms to the motor stage. Second, it presents active and passive immunotherapy strategies targeting α‐synuclein and their potential in slowing down the disease progression.
Yong Peng +10 more
wiley +1 more source
Deferiprone inhibits histopathological signs in skin of CKDmice.
, 2015 (A) Histopathological findings in the skin of mice with CKD and CKD mice treated with 125 mg/kg deferiprone for 16 weeks. Representative images are of dorsal skin biopsies of each group at 200X magnification H&E stained sections.
Oleg Karaduta (787139) +6 more
core +1 more source
Brain Sciences, 2018 The CAALA (Complex Augmentation of ALA) regimen was developed with the goal of redressing some of the weaknesses of 5-aminolevulinic acid (5-ALA) use in glioblastoma treatment as it now stands.
Richard E. Kast +8 more
doaj +1 more source
Generation of reactive oxygen species by hydroxypyridone compound/iron complexes
Redox Report, 2020 Objectives: Prooxidant properties of iron-binding hydroxypyridone compounds including deferiprone and mimosine were analyzed. Methods: Hydroxypyridone/iron-dependent production of reactive oxygen species was evidenced by the inactivation of aconitase ...
Keiko Murakami, Masataka Yoshino
doaj +1 more source
Plasmacytoid Dendritic Cells Exhibit High Transferrin Receptor Expression Without Iron Accumulation
European Journal of Immunology, Volume 56, Issue 6, June 2026.• pDCs are defined by high surface TFRC expression and dynamic iron flux, distinguishing them from conventional dendritic cell subsets. • In the Iron proteome, pDC are enriched for mitochondrial heme and Fe–S proteins but have similar iron storage to cDC. • Iron chelation does not disrupt pDC type‐1 IFN production. ABSTRACT Plasmacytoid dendritic cells
Carrie Corkish +7 more
wiley +1 more source
, 2017 Crescentic glomerulonephritis represents the most severe form of antibody-mediated glomerulonephritis. It is an important cause of renal dysfunction worldwide and there is a need for more effective treatment.
Tai-Di Chen +6 more
core +1 more source
Haematologica, 2012 Background Plasma non-transferrin bound iron refers to heterogeneous plasma iron species, not bound to transferrin, which appear in conditions of iron overload and ineffective erythropoiesis.
Yesim Aydinok +3 more
doaj +1 more source
Evidence Suggesting a Role of Iron in a Mouse Model of Nephrogenic Systemic Fibrosis. [PDF]
PLoS ONE, 2015 Nephrogenic systemic fibrosis is associated with gadolinium contrast exposure in patients with reduced kidney function and carries high morbidity and mortality.
Chhanda Bose +6 more
doaj +1 more source