Results 41 to 50 of about 6,396 (177)
Effect of deferiprone on cell cytotoxicity.
, 2015 (A) Light microscopic images on day 0 shows an equal number of PBMCs for each group. (B) LDH release by PBMC after treatment with deferiprone for 8 days.
Oleg Karaduta (787139) +6 more
core +1 more source
Key Interventions in Friedreich's Ataxia and Their Impact on Patient Outcomes: A Systematic Review
Movement Disorders, Volume 41, Issue 10, Page 2564-2591, October 2026.Abstract Friedreich's ataxia (FA) is a rare neurodegenerative disease with multisystemic symptoms that requires multidisciplinary care. This systematic review summarizes available pharmacological and nonpharmacological interventions, their outcomes, and alignment with patient‐centered care domains, as well as their impact on these domains.
Dorota Sarwinska +6 more
wiley +1 more source
Deferiprone inhibits histopathological signs in skin of CKDmice.
, 2015 (A) Histopathological findings in the skin of mice with CKD and CKD mice treated with 125 mg/kg deferiprone for 16 weeks. Representative images are of dorsal skin biopsies of each group at 200X magnification H&E stained sections.
Oleg Karaduta (787139) +6 more
core +1 more source
Hemodialysis International, Volume 30, Issue 4, Page 745-756, October 2026.ABSTRACT Background Iron overload in chronic kidney disease contributes to oxidative injury. The role of iron chelators, standard in transfusion‐related overload, remains unclear in chronic kidney disease. Aim To evaluate the efficacy and safety of iron chelators in adults with chronic kidney disease.
Humam Emad Rajha +6 more
wiley +1 more source
Effect of deferiprone in transwell-cultured confluent ECC-1 cells: Epithelial monolayer integrity.
, 2016 Cultures at maximal luminal barrier function (TER ≥ 1000 ohms / cm2) were left untreated, or were treated with deferiprone at the indicated concentrations, every day via the apical chamber and every other day via the basolateral chamber.
Myung Hee Park (176990) +13 more
core +1 more source
Iron Homeostasis and Liver Diseases
Journal of Cellular and Molecular Medicine, Volume 30, Issue 20, October 2026.ABSTRACT Iron is an essential micronutrient whose ability to cycle between ferric (Fe3+) and ferrous (Fe2+) states makes it crucial for physiological processes, including oxygen transport, DNA synthesis, and oxidative phosphorylation. However, because both deficiency and excess can cause severe pathology, precise regulation is critical. The liver plays
Peng Yang +6 more
wiley +1 more source
Brain‐X, Volume 4, Issue 3, September 2026.The potential connection between chronic fatigue syndrome (CFS) and ferroptosis has been explored within the mechanisms of neuroinflammation and oxidative stress, revealing that the occurrence of intracellular ferroptosis may be one of the crucial mechanisms leading to the onset of CFS.
Guiping Wang +15 more
wiley +1 more source
Risks associated with oral deferiprone in the treatment of infratentorial superficial siderosis [PDF]
, 2019 OBJECTIVE: Deferiprone is an iron chelator that has recently been used to treat patients with infratentorial superficial siderosis (iSS). It is considered to have a generally favourable safety profile but concerns have been raised due to the risk of ...
Cowley, P +7 more
core +1 more source
Brain Sciences, 2018 The CAALA (Complex Augmentation of ALA) regimen was developed with the goal of redressing some of the weaknesses of 5-aminolevulinic acid (5-ALA) use in glioblastoma treatment as it now stands.
Richard E. Kast +8 more
doaj +1 more source