Solubility of mesalazine in pseudo-binary mixtures of choline chloride/ethylene glycol deep eutectic solvent and water at 293.15 K to 313.15 K. [PDF]
BMC Chem, 2023 Mesalazine (5-ASA) is a medication utilized to treat inflammatory bowel diseases involving ulcerative colitis and Crohn’s disease. Mesalazine has fewer side effects but the low solubility and bioavailability of it is responsible for its delayed onset of ...
Armani E +5 more
europepmc +3 more sources
International Journal of Pharmaceutics, 1999 Previously published cosolvency models are critically evaluated in terms of their ability to mathematically correlate solute solubility in binary solvent mixtures as a function of solvent composition. Computational results show that the accuracy of the models is improved by increasing the number of curve-fit parameters.
A Jouyban-Gharamaleki +2 more
exaly +9 more sources
Solubility of Cinnarizine in (Transcutol + Water) Mixtures: Determination, Hansen Solubility Parameters, Correlation, and Thermodynamics. [PDF]
Molecules, 2021 Between 293.2 and 313.2 K and at 0.1 MPa, the solubility of the weak base, cinnarizine (CNZ) (3), in various {Transcutol-P (TP) (1) + water (2)} combinations is reported.
Shakeel F, Kazi M, Alanazi FK, Alam P.
europepmc +3 more sources
Measurement and correlation of solubility data for deferiprone in propylene glycol and 2-propanol at different temperatures. [PDF]
Heliyon, 2023 This investigation dealt with the thermodynamic properties, saturated solubility values, and solvation behavior of deferiprone as an oral iron chelator agent in non-aqueous mixtures of propylene glycol and 2-propanol using experimental measurements and ...
Rezaei H +3 more
europepmc +2 more sources
Review of the cosolvency models for predicting solubility of drugs in water-cosolvent mixtures
Journal of Pharmacy & Pharmaceutical Sciences, 2008 The cosolvency models presented from 1960 to 2007 were reviewed and their accuracies for correlating and/or predicting the solubility of drugs in water-cosolvent mixtures were discussed.
Abolghasem Jouyban
doaj +4 more sources
Solubility and thermodynamic study of deferiprone in propylene glycol and ethanol mixture. [PDF]
BMC Chem, 2023 This work aims to obtain the solubility, density and thermodynamic parameters of deferiprone in propylene glycol and ethanol. For this purpose, a shake-flask technique was applied for solid–liquid equilibration and the spectrophotometry method was ...
Radmand S +4 more
europepmc +2 more sources
Review of the Cosolvency Models for Predicting Drug Solubility in Solvent Mixtures: An Update
Journal of Pharmacy & Pharmaceutical Sciences, 2019 The cosolvency models frequently used in solubility data modeling of drugs in mixed solvents were reviewed and their accuracies for calculating the solubility of solutes were briefly discussed.
Abolghasem Jouyban
doaj +4 more sources
Experimental measurement, thermodynamic analysis, and mathematical modeling for budesonide solubility in 1-propanol + water mixtures at T = (293.2 to 313.2) K. [PDF]
BMC ChemBudesonide (BDS) a steroid-based anti-inflammatory drug widely prescribed for various diseases, has a low aqueous solubility. In this study, we investigated cosolvency approach to study the thermodynamic specifications related to the solubility of BDS at
Mohammadian E +3 more
europepmc +2 more sources
Investigation of the solubility and thermodynamics of salicylic acid in 2-propanol and ethylene glycol/propylene glycol binary solvent mixtures at (293.15 to 313.15) K. [PDF]
BMC ChemThis study aimed to measure both the solubility and thermodynamics of salicylic acid in binary solvent mixtures of (2-propanol + ethylene glycol) and (2-propanol + propylene glycol) at different temperatures in the range of 293.2–313.2 K.
Dabagh F +6 more
europepmc +2 more sources
Employment of Alginate Floating In Situ Gel for Controlled Delivery of Celecoxib: Solubilization and Formulation Studies. [PDF]
Biomed Res Int, 2020 Celecoxib (CXB) is a COX‐2‐selective nonsteroidal anti‐inflammatory drug used to control pain and various inflammatory conditions. CXB has limited oral bioavailability and a slow dissociation rate due to its poor water solubility. In order to enhance the oral bioavailability of CXB and reduce the frequency of administration, the present study was aimed
Abdul Rasool BK +3 more
europepmc +2 more sources