Solubility of 5-nitroisophthalic acid in pseudo-binary mixtures containing water and betaine-based deep eutectic solvents: effect of benzene ring substituents in the benzene carboxylic acid-based compounds on their solubility values. [PDF]
BMC ChemThis work aimed to report the equilibrium solubility of 5-nitroisophthalic acid (5-NIPA) in solvent mixtures of betaine/propylene glycol (Bet/PG) deep eutectic solvent (DES) (1:5 molar ratio) + water, betaine/ethylene glycol (Bet/EG) DES (1:3 molar ratio)
Jafari P +3 more
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Solubility of Bosentan in Polyethylene Glycol 400 + Water Mixtures: Experimental and Mathematical Computations [PDF]
Pharmaceutical Sciences, 2023 Background: To discover the optimal solvent amounts for using in a particular application, it is vital to achieve some useful information in regard with suitable neat or mixed solvent and drugs equilibrium solubility in them.
Parisa Jafari +2 more
doaj +2 more sources
Thermodynamic solubility of piroxicam in propylene glycol + water mixtures at 298.2-323.2 K: Data report and modeling [PDF]
Journal of the Serbian Chemical Society, 2015 The solubility of piroxicam (66 data points) in binary mixtures of propylene glycol (PG) + water at six different temperatures which ranged from 298.2 K to 323.2 K were reported.
Soltanpour Shahla, Bastami Zahra
doaj +2 more sources
A Unified Cosolvency Model for Calculating Solute Solubility in Mixed Solvents
Chemical and Pharmaceutical Bulletin, 2005 Organic solvents are amongst the most powerful solubilization agents for a large number of water-insoluble drugs. A number of equations has been reported for mathematical representation of solute solubility in mixed solvents. The question is then posed--is there a mathematical difference between these models?
Abolghasem Jouyban +2 more
exaly +5 more sources
Crystals, 2022 Florfenicol is an excellent antibiotic and is widely used in animal bacterial diseases. However, its poor water solubility leads to various problems, such as poor absorption and bioavailability.
Xinyuan Zhang +3 more
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Solubility of Sulfamethazine in Acetonitrile-Ethanol Cosolvent Mixtures: Thermodynamic Analysis and Mathematical Modeling. [PDF]
MoleculesThe low water solubility of sulfamethazine (SMT) limits its clinical efficacy, making it crucial to study techniques such as cosolvency to optimize pharmaceutical formulations. This study aimed to thermodynamically evaluate the solubility of SMT in {acetonitrile (MeCN) + ethanol (EtOH)} cosolvent mixtures over a temperature range of 278.15 to 318.15 K ...
Caviedes-Rubio DI +5 more
europepmc +3 more sources
Solubility of Sulfamerazine in Acetonitrile + Ethanol Cosolvent Mixtures: Thermodynamics and Modeling. [PDF]
MoleculesSulfamerazine (SMR) is a drug used as an antibacterial agent in the treatment of some pathologies, such as bronchitis, prostatitis and urinary tract infections. Although this drug was developed in 1945 and, due to its toxicity, was partially displaced by penicillin, due to the current problem of bacterial resistance, compounds such as SMR have regained
Ortiz CP +3 more
europepmc +4 more sources
Molecules, 2019 The current research work was performed to evaluate the solubilization behavior, solution thermodynamics, and solvation behavior of poorly soluble pyridazinone derivative i.e., 6-phenyl-pyridazin-3(2H)-one (PPD) in various binary solvent systems of ...
Faiyaz Shakeel +5 more
doaj +2 more sources
Chemical Thermodynamics and Thermal AnalysisThe solubility characteristics of amlodipine besylate (ADB) in various propylene glycol and 1-propanol mixtures were quantitatively determined using a spectrophotometric approach, post equilibration via the established shake-flask technique.
Homa Rezaei +3 more
doaj +2 more sources
Solubility Study of Acetylsalicylic Acid in Ethanol + Water Mixtures: Measurement, Mathematical Modeling, and Stability Discussion. [PDF]
AAPS PharmSciTech, 2021 Solubility determination of poorly water-soluble drugs is pivotal for formulation scientists when they want to develop a liquid formulation. Performing such a test with different ratios of cosolvents with water is time-consuming and costly.
Nokhodchi A +8 more
europepmc +2 more sources