Application of cosolvency and cocrystallization approach to enhance acyclovir solubility [PDF]
BMC ChemistryAcyclovir (ACY) is a commonly used antiviral drug with limited aqueous solubility and poor permeability. It is administered via oral and intravenous routes.
Elham Azad Khiabani +2 more
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Review of the cosolvency models for predicting solubility of drugs in water-cosolvent mixtures
Journal of Pharmacy & Pharmaceutical Sciences, 2008 The cosolvency models presented from 1960 to 2007 were reviewed and their accuracies for correlating and/or predicting the solubility of drugs in water-cosolvent mixtures were discussed.
Abolghasem Jouyban
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Sonication-assisted nonpolar-antisolvent approach to produce cellulose suspensions, disaggregated by a nonpolar-antisolvent with orthogonal Kamlet-Taft acidity/basicity: Roles of net-basicity and cosolvency [PDF]
Ultrasonics SonochemistryThis work reports a simple sonication-assisted approach to produce diluted (0.5 mg/mL) suspensions of cellulose in the non-functionalizing nonpolar-antisolvent tetrahydrofuran (THF), which has a purely basic character (null Kamlet-Taft acidity parameter,
Sergio E. Domínguez +5 more
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Solubility of mesalazine in pseudo-binary mixtures of choline chloride/ethylene glycol deep eutectic solvent and water at 293.15 K to 313.15 K [PDF]
BMC Chemistry, 2023 Mesalazine (5-ASA) is a medication utilized to treat inflammatory bowel diseases involving ulcerative colitis and Crohn’s disease. Mesalazine has fewer side effects but the low solubility and bioavailability of it is responsible for its delayed onset of ...
Elina Armani +5 more
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New Antifungal Compound: Impact of Cosolvency, Micellization and Complexation on Solubility and Permeability Processes [PDF]
Pharmaceutics, 2021 Poor solubility of new antifungal of 1,2,4-triazole class (S-119)—a structural analogue of fluconazole in aqueous media was estimated. The solubility improvement using different excipients: biopolymers (PEGs, PVP), surfactants (Brij S20, pluronic F-127 ...
Tatyana V. Volkova +2 more
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Measurement and correlation of solubility data for deferiprone in propylene glycol and 2-propanol at different temperatures [PDF]
Heliyon, 2023 This investigation dealt with the thermodynamic properties, saturated solubility values, and solvation behavior of deferiprone as an oral iron chelator agent in non-aqueous mixtures of propylene glycol and 2-propanol using experimental measurements and ...
Homa Rezaei +3 more
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Thermodynamic Study of the Solubility of Triclocarban in Polyethylene Glycol 200 + Water Cosolvent Mixtures at Different Temperatures [PDF]
MoleculesBackground: Solubility is a fundamental physicochemical property in pharmaceutical, chemical and environmental industrial processes. Regarding Triclocarban (TCC), a broad-spectrum antimicrobial, solubility is particularly challenging due to its low ...
Vanesa Puentes-Lozada +7 more
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Thermodynamic Assessment of Triclocarban Dissolution Process in N-Methyl-2-pyrrolidone + Water Cosolvent Mixtures [PDF]
Molecules, 2023 Solubility is one of the most important physicochemical properties due to its involvement in physiological (bioavailability), industrial (design) and environmental (biotoxicity) processes, and in this regard, cosolvency is one of the best strategies to ...
Diego Ivan Caviedes-Rubio +3 more
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Solubility and thermodynamic study of deferiprone in propylene glycol and ethanol mixture [PDF]
BMC Chemistry, 2023 This work aims to obtain the solubility, density and thermodynamic parameters of deferiprone in propylene glycol and ethanol. For this purpose, a shake-flask technique was applied for solid–liquid equilibration and the spectrophotometry method was ...
Samira Radmand +4 more
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Experimental measurement, thermodynamic analysis, and mathematical modeling for budesonide solubility in 1-propanol + water mixtures at T = (293.2 to 313.2) K [PDF]
BMC ChemistryBudesonide (BDS) a steroid-based anti-inflammatory drug widely prescribed for various diseases, has a low aqueous solubility. In this study, we investigated cosolvency approach to study the thermodynamic specifications related to the solubility of BDS at
Esmaeil Mohammadian +3 more
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