Results 31 to 40 of about 563 (201)

Solubility Enhancement of a Poorly Water‐Soluble Drug Using Hydrotropy and Mixed Hydrotropy‐Based Solid Dispersion Techniques

Advances in Pharmacological and Pharmaceutical Sciences, Volume 2022, Issue 1, 2022., 2022
Purpose. The biopharmaceutics classification system places rosuvastatin calcium in class II has a low and fluctuating oral bioavailability. The research focus is to maximize rosuvastatin calcium solubility in water and dissolution rate by employing and combining various hydrotropic agents to make a solid dispersion using solvent evaporation techniques.
Hezha Abdullah Ali, Hunar Kamal Omer, Benedetto Natalini   +2 more
wiley   +1 more source

Ternary Nanoswitches Realized with Multiresponsive PMMA‐b‐PNIPMAM Films in Mixed Water/Acetone Vapor Atmospheres

Advanced Engineering Materials, Volume 23, Issue 11, November 2021., 2021
Ternary nanoswitches are realized using PMMA‐b‐PNIPMAM diblock copolymer thin films. Three distinct film states (off, on, and standby) are successfully prepared by the combination of amphiphilicity and co‐nonsolvency effect. The exposure to N2, pure water vapor, and mixed 90 vol% water/10 vol% acetone vapor switches the films between dried, hydrated ...
Christina Geiger, Julija Reitenbach, Cristiane Henschel, Lucas P. Kreuzer, Tobias Widmann, Peixi Wang, Gaetano Mangiapia, Jean-François Moulin, Christine M. Papadakis, André Laschewsky, Peter Müller-Buschbaum   +10 more
wiley   +1 more source

Uncovering the Molecular Mechanisms of Cosolvency and Predicting the Cosolvency Phenomenon by Molecular Simulations: A Case Study of Amino Acids

, 2023
Cosolvency is an intriguing thermodynamic phenomenon. However, the lack of theoretical research restricts its development and its further applications.
Dongbo Wang, Fan Li (49953), Junbo Gong, Lina Zhou, Lina Zhou (473857), Mingyang Chen, Dongbo Wang (297090), Dandan Han, Tao Zhang (43681), Tao Zhang, Mingyang Chen (1397971), Fan Li, Jiahao Wei, Ying Wang, Jiahao Wei (8682204), Ying Wang (11406), Dandan Han (1582408), Junbo Gong (400138)   +17 more
core   +1 more source

Microarray Patches: Poking a Hole in the Challenges Faced When Delivering Poorly Soluble Drugs

Advanced Functional Materials, Volume 31, Issue 1, January 4, 2021., 2021
This review explores the delivery of hydrophobic compounds to the skin using microarray patches (MAPs). Initially designed to load low doses of hydrophilic and potent therapeutic agents, MAPs are now increasingly considered a viable strategy for the delivery of therapeutically relevant doses of poorly soluble drugs. This somewhat unexpected application
Alejandro J. Paredes, Peter E. McKenna, Inken K. Ramöller, Yara A. Naser, Fabiana Volpe‐Zanutto, Mingshan Li, M. T. A. Abbate, Li Zhao, Chunyang Zhang, Juhaina M. Abu‐Ershaid, Xianbing Dai, Ryan F. Donnelly   +11 more
wiley   +1 more source

Revealing the Molecular Mechanism of Cosolvency Based on Thermodynamic Phase Diagram, Molecular Simulation, and Spectrum Analysis: The Tolbutamide Case

, 2022
Cosolvency has been observed in many systems. To reveal the mechanism of cosolvency from the molecular level, the effects of molecular conformation, supramolecular clusters, and interactions on cosolvency were systematically investigated using ...
Ting Wang (16292), Xin Li (51274), Yingjie Ma, Na Wang (193263), Xin Huang (11077), Xin Li, Yunhai Huang (11585887), Yunhai Huang, Na Wang, Lina Zhou, Xiongtao Ji (11585884), Lina Zhou (473857), Hongxun Hao (1479568), Ting Wang, Xiongtao Ji, Hongxun Hao, Xin Huang, Yingjie Ma (1393597)   +17 more
core   +1 more source

Studies on the Incompatibility between Bulbus fritillariae and Radix aconiti praeparata Based on the P‐gp

Evidence-Based Complementary and Alternative Medicine, Volume 2021, Issue 1, 2021., 2021
Bulbus fritillariae and Radix aconiti praeparata are an incompatible herbal pair in the traditional Chinese medicine theory “eighteen incompatible medicaments,” and they should not be used simultaneously in clinical treatment for safety. This study aimed to investigate the incompatibility mechanism between Bulbus fritillariae and Radix aconiti ...
Weijun Liu, Ling Wei, Yoshikatsu Kanai, Xin He, Min Li   +4 more
wiley   +1 more source

Thermodynamic Study of Deferiprone Dissolution in Polyethylene Glycol 400 and 2-Propanol Mixture [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2023
In the current study, the solubility and density of deferiprone were determined in the polyethylene glycol (PEG) 400 and 2-propanol mixtures at 293.2 – 313.2 K using a shake-flask method before a spectrophotometric method.
Mahsa Ahmadi, Homa Rezaei, Hongkun Zhao, Elaheh Rahimpour, Abolghasem Jouyban   +4 more
doaj   +1 more source

Solution thermodynamics of methocarbamol in some ethanol + water mixtures

Química Nova, 2012
Apparent thermodynamic functions, Gibbs energy, enthalpy and entropy of solution and mixing, for methocarbamol in ethanol + water mixtures, were evaluated from solubility data determined at temperatures from 293.15 K to 313.15 K and from calorimetric ...
Katia C. Mercado, Gerson A. Rodríguez, Daniel R. Delgado, Fleming Martínez, Asma Romdhani   +4 more
doaj   +1 more source

SOLUBILIZATION OF CARBAMAZEPINE USING COSOLVENTS [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 1983
Solubilization of Carbamazepine was achieved through cosolvency using binary or ternary solvent systems at 25°. It was found that the aqueous solubility of the medicament was increased. However, the extent of the solubility promoting effect was dependent
S. Ahmed, A. Aboutaleb
doaj   +1 more source

Solubility of Bosentan in Polyethylene Glycol 400 + Water Mixtures: Experimental and Mathematical Computations [PDF]

Pharmaceutical Sciences, 2023
Background: To discover the optimal solvent amounts for using in a particular application, it is vital to achieve some useful information in regard with suitable neat or mixed solvent and drugs equilibrium solubility in them.
Parisa Jafari, Elahahe Rahimpour, Abolghasem Jouyban   +2 more
doaj   +1 more source