Results 31 to 40 of about 409 (199)
Crystals, 2022 Florfenicol is an excellent antibiotic and is widely used in animal bacterial diseases. However, its poor water solubility leads to various problems, such as poor absorption and bioavailability.
Xinyuan Zhang +3 more
doaj +1 more source
BioMed Research International, Volume 2023, Issue 1, 2023., 2023 Nanoemulgels are considered as potential and ideal drug delivery systems for the transdermal administration of poorly soluble drugs like lornoxicam. Their intrinsic characteristics, such as small globule size as well as excipient type, make transdermal passage of the drug easier.
Muhammad Shafiq +9 more
wiley +1 more source
Advanced Science, Volume 9, Issue 36, December 28, 2022., 2022 Computer simulations predict supramolecular formation of pyrazole‐modified monomers. Based on the simulations, selected monomers are used in the template‐free and facile upscalable precipitation polymerization to obtain anisotropic microgels (from spherical, raspberry‐like to dumbbell‐like).
Frédéric Grabowski +6 more
wiley +1 more source
Advances in Pharmacological and Pharmaceutical Sciences, Volume 2022, Issue 1, 2022., 2022 Purpose. The biopharmaceutics classification system places rosuvastatin calcium in class II has a low and fluctuating oral bioavailability. The research focus is to maximize rosuvastatin calcium solubility in water and dissolution rate by employing and combining various hydrotropic agents to make a solid dispersion using solvent evaporation techniques.
Hezha Abdullah Ali +2 more
wiley +1 more source
Advanced Engineering Materials, Volume 23, Issue 11, November 2021., 2021 Ternary nanoswitches are realized using PMMA‐b‐PNIPMAM diblock copolymer thin films. Three distinct film states (off, on, and standby) are successfully prepared by the combination of amphiphilicity and co‐nonsolvency effect. The exposure to N2, pure water vapor, and mixed 90 vol% water/10 vol% acetone vapor switches the films between dried, hydrated ...
Christina Geiger +10 more
wiley +1 more source
Microarray Patches: Poking a Hole in the Challenges Faced When Delivering Poorly Soluble Drugs
Advanced Functional Materials, Volume 31, Issue 1, January 4, 2021., 2021 This review explores the delivery of hydrophobic compounds to the skin using microarray patches (MAPs). Initially designed to load low doses of hydrophilic and potent therapeutic agents, MAPs are now increasingly considered a viable strategy for the delivery of therapeutically relevant doses of poorly soluble drugs. This somewhat unexpected application
Alejandro J. Paredes +11 more
wiley +1 more source
Evidence-Based Complementary and Alternative Medicine, Volume 2021, Issue 1, 2021., 2021 Bulbus fritillariae and Radix aconiti praeparata are an incompatible herbal pair in the traditional Chinese medicine theory “eighteen incompatible medicaments,” and they should not be used simultaneously in clinical treatment for safety. This study aimed to investigate the incompatibility mechanism between Bulbus fritillariae and Radix aconiti ...
Weijun Liu +4 more
wiley +1 more source
Cosolvency Studies of Polyethylene. Part-II : Viscometric Studies in Different Cosolvent Media
, 1982 Department of Physical Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Calcutta.-700 032 Manuscript received 14 May 1980, revised 14 July 1981, accepted 26 February 1982 Polyethylene (PE), though insoluble in all solvents near room temperature, has been found to be soluble in a number of binary mixtures, one of which is CS2 ...
NITA VIDYARTHI, SANTI R. PALIT
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Thermodynamic Study of Deferiprone Dissolution in Polyethylene Glycol 400 and 2-Propanol Mixture [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2023 In the current study, the solubility and density of deferiprone were determined in the polyethylene glycol (PEG) 400 and 2-propanol mixtures at 293.2 – 313.2 K using a shake-flask method before a spectrophotometric method.
Mahsa Ahmadi +4 more
doaj +1 more source
EXPRORER: Rational Cosolvent Set Construction Method for Cosolvent Molecular Dynamics Using Large-Scale Computation [PDF]
Journal of Chemical Information and Modeling, 2021 Cosolvent molecular dynamics (CMD) simulations involve an MD simulation of a protein in the presence of explicit water molecules mixed with cosolvent molecules to perform hotspot detection, binding site identification, and binding energy estimation, while other existing methods (e.g., MixMD, SILCS, and MDmix) utilize small molecules that represent ...
Keisuke Yanagisawa +3 more
openaire +2 more sources