Results 51 to 60 of about 563 (201)
The Hydrophobic Effect and the Role of Cosolvents
The Journal of Physical Chemistry B, 2017 Abstract Cosolvents modulate aqueous solubility, hydrophobic interactions, and the stability and function of most proteins in the living cell. Our molecular-level understanding of cosolvent effects is incomplete, not only at the level of complex systems such as proteins, but also at the level of very fundamental interactions that ...
Nico F. A. van der Vegt, Divya Nayar
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Physicochemical Characterization and Cyclodextrin Complexation of the Anticancer Drug Lapatinib
Journal of Chemistry, Volume 2017, Issue 1, 2017., 2017 Lapatinib (LAP), the tyrosine kinase inhibitor drug with moderate bioavailability, was characterized in terms of physicochemical properties: acid‐base characteristics, lipophilicity, and solubility. The highly lipophilic nature of the drug and its extremely low water solubility (S0 = 0.82 nM) limit the development of a parenteral formulation.
Gergő Tóth +7 more
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Prediction of benzodiazepines solubility using different cosolvency models
, 2002 The solubility of four benzodiazepines (BZPs) including diazepam (DIZ), lorazepam (LRZ) clonazepam (CLZ), and chlordiazepoxide (CHZ) in water-cosolvent (ethanol propylene glycol and polyethylene glycol 200) binary systems were studied.
Shokri, Javad +7 more
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Macromolecular Rapid Communications, Volume 47, Issue 21, 6 November 2026.The cononsolvency of poly(dimethyl acrylamide‐co‐hydroxyethyl acrylamide) copolymers in water‐acetonitrile mixtures enables the synthesis of hydrogels with finely tuned porosity. Optimized for droplet‐based microfluidics, this approach facilitates the fabrication of porous microgels with tunable mechanical and diffusion properties, offering precise ...
Maria I. Pieper +4 more
wiley +1 more source
BioMed Research International, Volume 2015, Issue 1, 2015., 2015 Most of the cytotoxic chemotherapeutic agents have poor aqueous solubility. These molecules are associated with poor physicochemical and biopharmaceutical properties, which makes the formulation difficult. An important approach in this regard is the use of combination of cyclodextrin and nanotechnology in delivery system.
Bina Gidwani +2 more
wiley +1 more source
Electrolyte Solvation Chemistry and Systemic Safety in Potassium‐Ion Batteries
Small Structures, Volume 7, Issue 11, November 2026.Electrolyte solvation chemistry determines the interphase that governs potassium‐ion battery performance, regardless of whether the electrode or the electrolyte is the focus of design. This review separates studies that engineer the solvation structure from those that adopt an electrolyte without examining it, and shows that thermal safety is an ...
Chase L. Clements, Vilas G. Pol
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Development of Orodispersible Tablets of Candesartan Cilexetil‐β‐cyclodextrin Complex
Journal of Pharmaceutics, Volume 2013, Issue 1, 2013., 2013 The aim of this study was to investigate the use of inclusion complexation technique employing β‐cyclodextrin in improving the dissolution profile of candesartan cilexetil, a BCS class‐II drug, and to formulate the inclusion complex into orodispersible tablets.
Maddukuri Sravya +5 more
wiley +1 more source
Review of the Cosolvency Models for Predicting Drug Solubility in Solvent Mixtures: An Update
Journal of Pharmacy & Pharmaceutical Sciences, 2019 The cosolvency models frequently used in solubility data modeling of drugs in mixed solvents were reviewed and their accuracies for calculating the solubility of solutes were briefly discussed.
Abolghasem Jouyban
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Pharmaceutics, 2022 (1) Background: Sutures with triclosan (TS) are used to reduce the risk of surgical site infections (SSI), but most clinical trials are inconclusive. The traceability of SSI risk to antimicrobial activity in operated tissues is needed.
Frederic Christopher Daoud +2 more
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Journal of Nanotechnology, Volume 2026, Issue 1, 2026.The combination of ethyl acetate fraction of Begonia medicinalis and ethanol fraction of Moringa oleifera was developed into self‐nanoemulsifying drug delivery system (SNEDDS) to increase the solubility of combined fraction. This study aims to determine the optimal concentrations of virgin coconut oil (VCO), Tween 80, and propylene glycol using the D ...
Muhammad Sulaiman Zubair +6 more
wiley +1 more source