Results 51 to 60 of about 409 (199)

A Comprehensive Review on Cyclodextrin‐Based Carriers for Delivery of Chemotherapeutic Cytotoxic Anticancer Drugs

BioMed Research International, Volume 2015, Issue 1, 2015., 2015
Most of the cytotoxic chemotherapeutic agents have poor aqueous solubility. These molecules are associated with poor physicochemical and biopharmaceutical properties, which makes the formulation difficult. An important approach in this regard is the use of combination of cyclodextrin and nanotechnology in delivery system.
Bina Gidwani, Amber Vyas, Spyros S. Skandalis   +2 more
wiley   +1 more source

Development of Orodispersible Tablets of Candesartan Cilexetil‐β‐cyclodextrin Complex

Journal of Pharmaceutics, Volume 2013, Issue 1, 2013., 2013
The aim of this study was to investigate the use of inclusion complexation technique employing β‐cyclodextrin in improving the dissolution profile of candesartan cilexetil, a BCS class‐II drug, and to formulate the inclusion complex into orodispersible tablets.
Maddukuri Sravya, Rajamanickam Deveswaran, Srinivasan Bharath, Basappa Veerbadraiah Basavaraj, Varadharajan Madhavan, Giuseppina De Simone   +5 more
wiley   +1 more source

A Study on Solubilization of Poorly Soluble Drugs by Cyclodextrins and Micelles: Complexation and Binding Characteristics of Sulfamethoxazole and Trimethoprim

The Scientific World Journal, Volume 2012, Issue 1, 2012., 2012
The present study is focused on the characterization of solubilization of poorly soluble drugs, that is, sulfamethoxazole (SMX) and trimethoprim (TMP) by cyclodextrins (α‐, β‐, and γ‐CDs) and anionic surfactant sodium dodecyl sulfate (SDS). The phase solubility diagrams drawn from UV spectral measurements are of the AL type and indicate an enhancement ...
Sinem Göktürk, Elif Çalışkan, R. Yeşim Talman, Umran Var, Yadavalli Venkata Nageswar, Parvin Zakeri-Milani   +5 more
wiley   +1 more source

Drug Solubility: Importance and Enhancement Techniques

International Scholarly Research Notices, Volume 2012, Issue 1, 2012., 2012
Solubility, the phenomenon of dissolution of solute in solvent to give a homogenous system, is one of the important parameters to achieve desired concentration of drug in systemic circulation for desired (anticipated) pharmacological response. Low aqueous solubility is the major problem encountered with formulation development of new chemical entities ...
Ketan T. Savjani, Anuradha K. Gajjar, Jignasa K. Savjani, G. Aktay, Y.-Z. Du, J. Torrado   +5 more
wiley   +1 more source

How Long Do Implanted Triclosan Sutures Inhibit Staphylococcus aureus in Surgical Conditions? A Pharmacological Model

Pharmaceutics, 2022
(1) Background: Sutures with triclosan (TS) are used to reduce the risk of surgical site infections (SSI), but most clinical trials are inconclusive. The traceability of SSI risk to antimicrobial activity in operated tissues is needed.
Frederic Christopher Daoud, Ruben Goncalves, Nicholas Moore   +2 more
doaj   +1 more source

Prediction of a Broad Spectra of Membrane Morphologies Through a New NIPS Thermo‐Kinetic Model

Advances in Polymer Technology, Volume 2025, Issue 1, 2025.
This work presents a novel semiempirical mathematical approach consisting of a coupled thermo‐kinetic model as valuable tool for predicting the polymeric fraction profile of membranes synthesized by nonsolvent induced phase separation (NIPS). Equilibrium binodal curves (BCs) of the system component were incorporated to the Fick’s diffusive kinetic ...
Marta Romay, Ane Urtiaga, Nazely Diban, Nasir Ahmad   +3 more
wiley   +1 more source

A Novel Paclitaxel Microemulsion Containing a Reduced Amount of Cremophor EL: Pharmacokinetics, Biodistribution, and In Vivo Antitumor Efficacy and Safety

BioMed Research International, Volume 2011, Issue 1, 2011., 2011
The purpose of this study was to prepare a novel paclitaxel (PTX) microemulsion containing a reduced amount of Cremophor EL (CrEL) which had similar pharmacokinetics and antitumor efficacy as the commercially available PTX injection, but a significantly reduced allergic effect due to the CrEL.
Ying Wang, Ke-Chun Wu, Bing-Xiang Zhao, Xin Zhao, Xin Wang, Su Chen, Shu-Fang Nie, Wei-San Pan, Xuan Zhang, Qiang Zhang, Mark J. McKeage   +10 more
wiley   +1 more source

Lipid Horizons: Recent Advances and Future Prospects in LBDDS for Oral Administration of Antihypertensive Agents

International Journal of Hypertension, Volume 2024, Issue 1, 2024.
The lipid‐based drug delivery system (LBDDS) is a well‐established technique that is anticipated to bring about comprehensive transformations in the pharmaceutical field, impacting the management and administration of drugs, as well as treatment and diagnosis.
Preeti, Sharda Sambhakar, Rohit Malik, Saurabh Bhatia, Ahmed Al Harrasi, Renu Saharan, Geeta Aggarwal, Suresh Kumar, Renu Sehrawat, Chanchal Rani, Emanuele Pivetta   +10 more
wiley   +1 more source

A Review of Multidimensional, Multifluid, Intermediate‐Scale Experiments: Flow Behavior, Saturation Imaging, and Tracer Detection and Quantification

Vadose Zone Journal, Volume 6, Issue 3, Page 610-637, August 2007., 2007
A review is presented of original multidimensional, intermediate‐scale experiments involving nonaqueous phase liquid (NAPL) flow behavior, imaging, and detection and quantification with solute tracers. In a companion paper (Oostrom et al., 2006a), experiments related to aqueous dissolution and enhanced remediation were discussed.
M. Oostrom, J. H. Dane, T. W. Wietsma
wiley   +1 more source

Solubility and Apparent Specific Volume of Sucrose in Some Aqueous Polyethylene Glycol Mixtures at 298.2 K [PDF]

Pharmaceutical Sciences, 2018
Background: Sucrose is the most widely used sweetener in food and pharmaceuticals. Quantitative solubility values of this excipient in aqueous polyethylene glycol (PEG) mixtures is not abundant.
Dario A Tinjaca, Maria M Muñoz, Elaheh Rahimpour, Abolghasem Jouyban, Fleming Martinez, William E Acree Jr   +5 more
doaj   +1 more source