Results 41 to 50 of about 563 (201)

Solubilization of drugs. Formulation development perspective

open access: yes, 1999
This dissertation discusses some aspects of the solubilization of drugs from the perspective of the formulator. Chapter I emphasizes the importance of this research as well as the study of the practical aspects of aqueous solubilization of drugs.
Alvarez-Nunez, Fernando Antonio
core   +4 more sources

Thermodynamic study of the solubility of triclocarban in ethanol + propylene glycol mixtures

open access: yesQuímica Nova, 2012
By using the van't Hoff and Gibbs equations the apparent thermodynamic functions Gibbs energy, enthalpy, and entropy of solution for triclocarban in ethanol + propylene glycol mixtures were evaluated from solubility data determined at temperatures from ...
Andres R. Holguín   +2 more
doaj   +1 more source

Evaluation of Two Cosolvency Models to Predict Solute Partitioning between Polymers (LDPE) and Water - Ethanol Simulating Solvent Mixtures

open access: yes, 2022
733751Purpose: Binary water - ethanol mixtures, by mimicking a clinically relevant medium’s polarity-driven extraction strength, facilitate experimental modeling of patient exposure to chemicals which can potentially leach from a plastic material for ...
Egert, T., Langowski, Horst-Christian
core   +1 more source

Employment of Alginate Floating In Situ Gel for Controlled Delivery of Celecoxib: Solubilization and Formulation Studies

open access: yesBioMed Research International, Volume 2020, Issue 1, 2020., 2020
Celecoxib (CXB) is a COX‐2‐selective nonsteroidal anti‐inflammatory drug used to control pain and various inflammatory conditions. CXB has limited oral bioavailability and a slow dissociation rate due to its poor water solubility. In order to enhance the oral bioavailability of CXB and reduce the frequency of administration, the present study was aimed
Bazigha K. Abdul Rasool   +4 more
wiley   +1 more source

New Antifungal Compound: Impact of Cosolvency, Micellization and Complexation on Solubility and Permeability Processes

open access: yesPharmaceutics, 2021
Poor solubility of new antifungal of 1,2,4-triazole class (S-119)—a structural analogue of fluconazole in aqueous media was estimated. The solubility improvement using different excipients: biopolymers (PEGs, PVP), surfactants (Brij S20, pluronic F-127 ...
Tatyana V. Volkova   +2 more
doaj   +1 more source

New phase phenomena in ternary systems at high pressures - Cosolvency and miscibility windows up to 100 MPay [PDF]

open access: yes, 2020
For selected systems CO 2 + alkan-1-ol + alkane, new high-pressure phase phenomena have been found. Isobaric cosolvency effects and isothermal miscibility windows are presented phenomenologically and numerically. Additionally, rules for the occurrence of
Arndt L Scheidgenz, Gerhard M Schneider
core  

Solubility prediction of drugs in methanol + water mixtures using minimum number of data points: Comparison of various models

open access: yes, 2023
This work reports the ability of cosolvency and activity coefficient models in the prediction of drugs solubility in methanol + water mixtures by choosing a minimum number of experimental data point. For this purpose, the available solubility datasets of
Parisa Jafari (5447729)   +1 more
core   +1 more source

Thermodynamic study of the solubility of sodium naproxen in some ethanol + water mixtures

open access: yesQuímica Nova, 2010
By using the van't Hoff and Gibbs equations the apparent thermodynamic functions Gibbs energy, enthalpy, and entropy of solution for sodium naproxen in ethanol + water cosolvent mixtures, were evaluated from solubility data determined at temperatures ...
Daniel R. Delgado   +4 more
doaj   +1 more source

Thermodynamic Properties of 1,5-Pentanediamine Adipate Dihydrate in Three Binary Solvent Systems from 278.15 K to 313.15 K

open access: yesCrystals, 2022
In this work, solubility data of 1,5-pentanediamine adipate dihydrate in binary solvent systems of water + methanol, water + ethanol and water + N,N-dimethylformamide were experimentally measured via a static gravimetric method in the temperature range ...
Liang Li   +8 more
doaj   +1 more source

Facile preparation of optically transparent film of acetylated cellulose nanofiber-reinforced poly(methyl methacrylate) utilizing cosolvency in aqueous ethanol

open access: yes, 2023
Composite films of cellulose nanofibers (CNFs) and poly(methyl methacrylate) (PMMA) are fabricated typically by solution-casting using an organic solvent (e.g., chloroform) that can dissolve PMMA.
Iwata, Tadahisa   +4 more
core   +1 more source

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