Results 41 to 50 of about 486 (202)
Advances in Pharmacological and Pharmaceutical Sciences, Volume 2022, Issue 1, 2022., 2022 Purpose. The biopharmaceutics classification system places rosuvastatin calcium in class II has a low and fluctuating oral bioavailability. The research focus is to maximize rosuvastatin calcium solubility in water and dissolution rate by employing and combining various hydrotropic agents to make a solid dispersion using solvent evaporation techniques.
Hezha Abdullah Ali +2 more
wiley +1 more source
Advanced Engineering Materials, Volume 23, Issue 11, November 2021., 2021 Ternary nanoswitches are realized using PMMA‐b‐PNIPMAM diblock copolymer thin films. Three distinct film states (off, on, and standby) are successfully prepared by the combination of amphiphilicity and co‐nonsolvency effect. The exposure to N2, pure water vapor, and mixed 90 vol% water/10 vol% acetone vapor switches the films between dried, hydrated ...
Christina Geiger +10 more
wiley +1 more source
Application of the Solute-Solvent Intermolecular Interactions as Indicator of Caffeine Solubility in Aqueous Binary Aprotic and Proton Acceptor Solvents: Measurements and Quantum Chemistry Computations. [PDF]
Materials (Basel), 2022 The solubility of caffeine in aqueous binary mixtures was measured in five aprotic proton acceptor solvents (APAS) including dimethyl sulfoxide, dimethylformamide, 1,4-dioxane, acetonitrile, and acetone.
Jeliński T, Kubsik M, Cysewski P.
europepmc +2 more sources
Stabilization of eptifibatide by cosolvents [PDF]
International Journal of Pharmaceutics, 2001 Eptifibatide is a potent and highly specific inhibitor of platelet receptor glycoprotein IIb/IIIa and is indicated in the treatment of acute coronary syndrome. The commercial product Integrilin(R) (eptifibatide) Injection requires a cold/refrigerator storage condition.
L, Zhao, S H, Yalkowsky
openaire +2 more sources
Microarray Patches: Poking a Hole in the Challenges Faced When Delivering Poorly Soluble Drugs
Advanced Functional Materials, Volume 31, Issue 1, January 4, 2021., 2021 This review explores the delivery of hydrophobic compounds to the skin using microarray patches (MAPs). Initially designed to load low doses of hydrophilic and potent therapeutic agents, MAPs are now increasingly considered a viable strategy for the delivery of therapeutically relevant doses of poorly soluble drugs. This somewhat unexpected application
Alejandro J. Paredes +11 more
wiley +1 more source
Evidence-Based Complementary and Alternative Medicine, Volume 2021, Issue 1, 2021., 2021 Bulbus fritillariae and Radix aconiti praeparata are an incompatible herbal pair in the traditional Chinese medicine theory “eighteen incompatible medicaments,” and they should not be used simultaneously in clinical treatment for safety. This study aimed to investigate the incompatibility mechanism between Bulbus fritillariae and Radix aconiti ...
Weijun Liu +4 more
wiley +1 more source
, 2023 Cosolvency is an intriguing thermodynamic phenomenon. However, the lack of theoretical research restricts its development and its further applications.
Dongbo Wang +17 more
core +1 more source
Thermodynamic Study of Deferiprone Dissolution in Polyethylene Glycol 400 and 2-Propanol Mixture [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2023 In the current study, the solubility and density of deferiprone were determined in the polyethylene glycol (PEG) 400 and 2-propanol mixtures at 293.2 – 313.2 K using a shake-flask method before a spectrophotometric method.
Mahsa Ahmadi +4 more
doaj +1 more source
Solution thermodynamics of methocarbamol in some ethanol + water mixtures
Química Nova, 2012 Apparent thermodynamic functions, Gibbs energy, enthalpy and entropy of solution and mixing, for methocarbamol in ethanol + water mixtures, were evaluated from solubility data determined at temperatures from 293.15 K to 313.15 K and from calorimetric ...
Katia C. Mercado +4 more
doaj +1 more source
, 2022 733751Purpose: Binary water - ethanol mixtures, by mimicking a clinically relevant medium’s polarity-driven extraction strength, facilitate experimental modeling of patient exposure to chemicals which can potentially leach from a plastic material for ...
Egert, T., Langowski, Horst-Christian
core +1 more source