Results 61 to 70 of about 486 (202)

Physicochemical Characterization and Cyclodextrin Complexation of the Anticancer Drug Lapatinib

Journal of Chemistry, Volume 2017, Issue 1, 2017., 2017
Lapatinib (LAP), the tyrosine kinase inhibitor drug with moderate bioavailability, was characterized in terms of physicochemical properties: acid‐base characteristics, lipophilicity, and solubility. The highly lipophilic nature of the drug and its extremely low water solubility (S0 = 0.82 nM) limit the development of a parenteral formulation.
Gergő Tóth, Ádám Jánoska, Gergely Völgyi, Zoltán-István Szabó, Gábor Orgován, Arash Mirzahosseini, Béla Noszál, Jaime Villaverde   +7 more
wiley   +1 more source

The Hydrophobic Effect and the Role of Cosolvents

The Journal of Physical Chemistry B, 2017
Cosolvents modulate aqueous solubility, hydrophobic interactions, and the stability and function of most proteins in the living cell. Our molecular-level understanding of cosolvent effects is incomplete, not only at the level of complex systems such as proteins, but also at the level of very fundamental interactions that underlie the hydrophobic effect.
Nico F. A. van der Vegt, Divya Nayar
openaire   +2 more sources

A Comprehensive Review on Cyclodextrin‐Based Carriers for Delivery of Chemotherapeutic Cytotoxic Anticancer Drugs

BioMed Research International, Volume 2015, Issue 1, 2015., 2015
Most of the cytotoxic chemotherapeutic agents have poor aqueous solubility. These molecules are associated with poor physicochemical and biopharmaceutical properties, which makes the formulation difficult. An important approach in this regard is the use of combination of cyclodextrin and nanotechnology in delivery system.
Bina Gidwani, Amber Vyas, Spyros S. Skandalis   +2 more
wiley   +1 more source

Development of Orodispersible Tablets of Candesartan Cilexetil‐β‐cyclodextrin Complex

Journal of Pharmaceutics, Volume 2013, Issue 1, 2013., 2013
The aim of this study was to investigate the use of inclusion complexation technique employing β‐cyclodextrin in improving the dissolution profile of candesartan cilexetil, a BCS class‐II drug, and to formulate the inclusion complex into orodispersible tablets.
Maddukuri Sravya, Rajamanickam Deveswaran, Srinivasan Bharath, Basappa Veerbadraiah Basavaraj, Varadharajan Madhavan, Giuseppina De Simone   +5 more
wiley   +1 more source

A Study on Solubilization of Poorly Soluble Drugs by Cyclodextrins and Micelles: Complexation and Binding Characteristics of Sulfamethoxazole and Trimethoprim

The Scientific World Journal, Volume 2012, Issue 1, 2012., 2012
The present study is focused on the characterization of solubilization of poorly soluble drugs, that is, sulfamethoxazole (SMX) and trimethoprim (TMP) by cyclodextrins (α‐, β‐, and γ‐CDs) and anionic surfactant sodium dodecyl sulfate (SDS). The phase solubility diagrams drawn from UV spectral measurements are of the AL type and indicate an enhancement ...
Sinem Göktürk, Elif Çalışkan, R. Yeşim Talman, Umran Var, Yadavalli Venkata Nageswar, Parvin Zakeri-Milani   +5 more
wiley   +1 more source

Adaptive Elastin‐Like Hydrogel with Unidirectional and Controllable Anisotropic Actuation for Soft Robotics and Tissue Engineering

Advanced Materials Technologies, Volume 10, Issue 17, September 4, 2025.
Fiber‐reinforced elastin‐like tubular scaffolds are engineered to achieve anisotropic and reversible actuation under external stimuli. By adjusting fiber's angle, actuation behavior is finely tuned, enabling distinct actuation responses, even within different regions of the same scaffold.
Federica Sallustio, Amanda Schmidt, Ikram El Maachi, Alexander Greenhalgh, Martin Frydrych, Stefan Jockenhoevel, José Carlos Rodríguez‐Cabello, Alicia Fernández‐Colino   +7 more
wiley   +1 more source

Drug Solubility: Importance and Enhancement Techniques

International Scholarly Research Notices, Volume 2012, Issue 1, 2012., 2012
Solubility, the phenomenon of dissolution of solute in solvent to give a homogenous system, is one of the important parameters to achieve desired concentration of drug in systemic circulation for desired (anticipated) pharmacological response. Low aqueous solubility is the major problem encountered with formulation development of new chemical entities ...
Ketan T. Savjani, Anuradha K. Gajjar, Jignasa K. Savjani, G. Aktay, Y.-Z. Du, J. Torrado   +5 more
wiley   +1 more source

Hydrotropy and Cosolvency in Lignin Solubilization with Deep Eutectic Solvents

, 2019
The mechanisms responsible for the good solubility of lignin in aqueous solutions of deep eutectic solvents are here investigated using both monomer model compounds and technical lignins (kraft and organosolv).
Paula C. Rodrigues Pinto (2080777), Armando J. D. Silvestre (1799347), Belinda Soares (3922526), Carmen S. R. Freire (1799332), João A. P. Coutinho (1268916)   +4 more
core   +1 more source

Review of the Cosolvency Models for Predicting Drug Solubility in Solvent Mixtures: An Update

Journal of Pharmacy & Pharmaceutical Sciences, 2019
The cosolvency models frequently used in solubility data modeling of drugs in mixed solvents were reviewed and their accuracies for calculating the solubility of solutes were briefly discussed.
Abolghasem Jouyban
doaj   +1 more source

How Long Do Implanted Triclosan Sutures Inhibit Staphylococcus aureus in Surgical Conditions? A Pharmacological Model

Pharmaceutics, 2022
(1) Background: Sutures with triclosan (TS) are used to reduce the risk of surgical site infections (SSI), but most clinical trials are inconclusive. The traceability of SSI risk to antimicrobial activity in operated tissues is needed.
Frederic Christopher Daoud, Ruben Goncalves, Nicholas Moore   +2 more
doaj   +1 more source