Results 11 to 20 of about 409 (199)

Review of the Cosolvency Models for Predicting Drug Solubility in Solvent Mixtures: An Update

Journal of Pharmacy & Pharmaceutical Sciences, 2019
The cosolvency models frequently used in solubility data modeling of drugs in mixed solvents were reviewed and their accuracies for calculating the solubility of solutes were briefly discussed.
Abolghasem Jouyban
doaj   +3 more sources

Investigation of the solubility and thermodynamics of salicylic acid in 2-propanol and ethylene glycol/propylene glycol binary solvent mixtures at (293.15 to 313.15) K [PDF]

BMC Chemistry
This study aimed to measure both the solubility and thermodynamics of salicylic acid in binary solvent mixtures of (2-propanol + ethylene glycol) and (2-propanol + propylene glycol) at different temperatures in the range of 293.2–313.2 K.
Fatemeh Dabagh, Fatemeh Khalili, Aynaz Zarghampour, Salar Hemmati, Jalal Hanaee, Elaheh Rahimpour, Abolghasem Jouyban   +6 more
doaj   +2 more sources

Experimental and Machine-Learning-Assisted Design of Pharmaceutically Acceptable Deep Eutectic Solvents for the Solubility Improvement of Non-Selective COX Inhibitors Ibuprofen and Ketoprofen [PDF]

Molecules
Deep eutectic solvents (DESs) are commonly used in pharmaceutical applications as excellent solubilizers of active substances. This study investigated the tuning of ibuprofen and ketoprofen solubility utilizing DESs containing choline chloride or betaine
Piotr Cysewski, Tomasz Jeliński, Maciej Przybyłek, Anna Mai, Julia Kułak   +4 more
doaj   +2 more sources

Solubility of Cinnarizine in (Transcutol + Water) Mixtures: Determination, Hansen Solubility Parameters, Correlation, and Thermodynamics [PDF]

Molecules, 2021
Between 293.2 and 313.2 K and at 0.1 MPa, the solubility of the weak base, cinnarizine (CNZ) (3), in various {Transcutol-P (TP) (1) + water (2)} combinations is reported.
Faiyaz Shakeel, Mohsin Kazi, Fars K. Alanazi, Prawez Alam   +3 more
doaj   +2 more sources

Solubility determination, mathematical modeling, and thermodynamic analysis of naproxen in binary solvent mixtures of (1-propanol/2-propanol) and ethylene glycol at different temperatures [PDF]

BMC Chemistry
This study investigates the solubility behavior of Naproxen (NAP) in binary solvent mixtures of 1-propanol (1-PrOH) and 2-propanol (2-PrOH) with ethylene glycol (EG) across a range of temperatures.
Mohammad Barzegar-Jalali, Atefeh Sheikhi-Sovari, Fleming Martinez, Behrouz Seyfinejad, Elaheh Rahimpour, Abolghasem Jouyban   +5 more
doaj   +2 more sources

Solubility of Sulfamethazine in Acetonitrile–Ethanol Cosolvent Mixtures: Thermodynamic Analysis and Mathematical Modeling [PDF]

Molecules
The low water solubility of sulfamethazine (SMT) limits its clinical efficacy, making it crucial to study techniques such as cosolvency to optimize pharmaceutical formulations.
Diego Ivan Caviedes-Rubio, Cristian Buendía-Atencio, Rossember Edén Cardenas-Torres, Claudia Patricia Ortiz, Fleming Martinez, Daniel Ricardo Delgado   +5 more
doaj   +2 more sources

Dissolution Thermodynamics of the Solubility of Sulfamethazine in (Acetonitrile + 1-Propanol) Mixtures [PDF]

Pharmaceuticals
Background: Solubility is one of the most important parameters in the research and development processes of the pharmaceutical industry. In this context, cosolubility is one of the most used strategies to improve the solubility of poorly soluble drugs ...
Daniel Ricardo Delgado, Jennifer Katiusca Castro-Camacho, Claudia Patricia Ortiz, Diego Ivan Caviedes-Rubio, Fleming Martinez   +4 more
doaj   +2 more sources

Deep Eutectic Solvents as Agents for Improving the Solubility of Edaravone: Experimental and Theoretical Considerations [PDF]

Molecules
In this study, both practical and theoretical aspects of the solubility of edaravone (EDA) in Deep Eutectic Solvents (DESs) were considered. The solubility of edaravone in some media, including water, can be limited, which creates the need for new ...
Tomasz Jeliński, Maciej Przybyłek, Magdalena Mianowana, Kinga Misiak, Piotr Cysewski   +4 more
doaj   +2 more sources

Solubility of 5-nitroisophthalic acid in pseudo-binary mixtures containing water and betaine-based deep eutectic solvents: effect of benzene ring substituents in the benzene carboxylic acid-based compounds on their solubility values [PDF]

BMC Chemistry
This work aimed to report the equilibrium solubility of 5-nitroisophthalic acid (5-NIPA) in solvent mixtures of betaine/propylene glycol (Bet/PG) deep eutectic solvent (DES) (1:5 molar ratio) + water, betaine/ethylene glycol (Bet/EG) DES (1:3 molar ratio)
Parisa Jafari, Mohammad Barzegar-Jalali, Salar Hemmati, Abolghasem Jouyban   +3 more
doaj   +2 more sources

Solubility Enhancement of Etoricoxib by Cosolvency Approach [PDF]

International Scholarly Research Notices, Volume 2012, Issue 1, 2012., 2012
The purpose of the present study was to examine and compare the cosolvency using three different cosolvents, namely PEG 400, PG, and glycerin on the aqueous solubility enhancement of a poorly aqueous soluble drug, etoricoxib, since solubilization of nonpolar drugs constitutes one of the important tasks in the formulation design of liquid dosage forms ...
Amit Kumar Nayak, Prachi Prava Panigrahi
openalex   +2 more sources