Results 31 to 40 of about 6,892,179 (134)
Physicochemical Characterization and Cyclodextrin Complexation of the Anticancer Drug Lapatinib
Journal of Chemistry, Volume 2017, Issue 1, 2017., 2017 Lapatinib (LAP), the tyrosine kinase inhibitor drug with moderate bioavailability, was characterized in terms of physicochemical properties: acid‐base characteristics, lipophilicity, and solubility. The highly lipophilic nature of the drug and its extremely low water solubility (S0 = 0.82 nM) limit the development of a parenteral formulation.
Gergő Tóth +7 more
wiley +1 more source
Molecules, 2019 The current research work was performed to evaluate the solubilization behavior, solution thermodynamics, and solvation behavior of poorly soluble pyridazinone derivative i.e., 6-phenyl-pyridazin-3(2H)-one (PPD) in various binary solvent systems of ...
Faiyaz Shakeel +5 more
doaj +1 more source
Plant‐Derived Natural Product Nanodelivery System in Cancer Therapy
Phytotherapy Research, EarlyView.This review comprehensively summarizes the recent progress and emerging concepts in nanotechnology‐based delivery systems for plant‐derived natural products, with a particular focus on their application in precision cancer therapy. ABSTRACT Plant‐derived natural products have emerged as important sources of anticancer agents because of their diverse ...
Changqi Shi +9 more
wiley +1 more source
BioMed Research International, Volume 2015, Issue 1, 2015., 2015 Most of the cytotoxic chemotherapeutic agents have poor aqueous solubility. These molecules are associated with poor physicochemical and biopharmaceutical properties, which makes the formulation difficult. An important approach in this regard is the use of combination of cyclodextrin and nanotechnology in delivery system.
Bina Gidwani +2 more
wiley +1 more source
Electrolyte Solvation Chemistry and Systemic Safety in Potassium‐Ion Batteries
Small Structures, Volume 7, Issue 11, November 2026.Electrolyte solvation chemistry determines the interphase that governs potassium‐ion battery performance, regardless of whether the electrode or the electrolyte is the focus of design. This review separates studies that engineer the solvation structure from those that adopt an electrolyte without examining it, and shows that thermal safety is an ...
Chase L. Clements, Vilas G. Pol
wiley +1 more source
Development of Orodispersible Tablets of Candesartan Cilexetil‐β‐cyclodextrin Complex
Journal of Pharmaceutics, Volume 2013, Issue 1, 2013., 2013 The aim of this study was to investigate the use of inclusion complexation technique employing β‐cyclodextrin in improving the dissolution profile of candesartan cilexetil, a BCS class‐II drug, and to formulate the inclusion complex into orodispersible tablets.
Maddukuri Sravya +5 more
wiley +1 more source
Journal of Nanotechnology, Volume 2026, Issue 1, 2026.The combination of ethyl acetate fraction of Begonia medicinalis and ethanol fraction of Moringa oleifera was developed into self‐nanoemulsifying drug delivery system (SNEDDS) to increase the solubility of combined fraction. This study aims to determine the optimal concentrations of virgin coconut oil (VCO), Tween 80, and propylene glycol using the D ...
Muhammad Sulaiman Zubair +6 more
wiley +1 more source
The Scientific World Journal, Volume 2012, Issue 1, 2012., 2012 The present study is focused on the characterization of solubilization of poorly soluble drugs, that is, sulfamethoxazole (SMX) and trimethoprim (TMP) by cyclodextrins (α‐, β‐, and γ‐CDs) and anionic surfactant sodium dodecyl sulfate (SDS). The phase solubility diagrams drawn from UV spectral measurements are of the AL type and indicate an enhancement ...
Sinem Göktürk +5 more
wiley +1 more source
, 2023 This study presents solubility determination and the thermodynamic analysis of celecoxib (CXB) in two kinds of solvent mixtures of N-methyl-2-pyrrolidone (NMP) + ethanol and NMP + 1-propanol at various temperatures (293.15–313.15 K).
Behrouz Seyfinejad (14333717) +5 more
core +1 more source
Advanced Materials Technologies, Volume 10, Issue 17, September 4, 2025.Fiber‐reinforced elastin‐like tubular scaffolds are engineered to achieve anisotropic and reversible actuation under external stimuli. By adjusting fiber's angle, actuation behavior is finely tuned, enabling distinct actuation responses, even within different regions of the same scaffold.
Federica Sallustio +7 more
wiley +1 more source