Results 21 to 30 of about 275 (175)

Thermodynamic Study of Deferiprone Dissolution in Polyethylene Glycol 400 and 2-Propanol Mixture [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2023
In the current study, the solubility and density of deferiprone were determined in the polyethylene glycol (PEG) 400 and 2-propanol mixtures at 293.2 – 313.2 K using a shake-flask method before a spectrophotometric method.
Mahsa Ahmadi, Homa Rezaei, Hongkun Zhao, Elaheh Rahimpour, Abolghasem Jouyban   +4 more
doaj   +1 more source

Budesonide Solubility in 2-Propanol+ Water Mixtures at T = (293.2 to 313.2) K: Experimental Measurement, Thermodynamic Analysis and Mathematical Modeling [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2023
A shake-flask method was used to investigate the solubility and thermodynamic properties of budesonide (BDS) in the temperature scope of 293.2-313.22 K in aqueous mixtures of 2-propanol.
Esmail Mohamadian, Sanaz Zargar Balaye Jame, Fazlollah Shokri, Mostafa Rostamnezhad, Seyed Hesam Sharifnia   +4 more
doaj   +1 more source

Biodegradable Polymeric Pharmaceutical Nanoemulgel Coloaded with Eucalyptol‐Lornoxicam: Fabrication and Characterizations for Possible Better Pain Management

BioMed Research International, Volume 2023, Issue 1, 2023., 2023
Nanoemulgels are considered as potential and ideal drug delivery systems for the transdermal administration of poorly soluble drugs like lornoxicam. Their intrinsic characteristics, such as small globule size as well as excipient type, make transdermal passage of the drug easier.
Muhammad Shafiq, Barkat Ali Khan, Sheikh Abdur Rashid, Muhammad Khalid Khan, Faiza Naseem, Ali M. Alqahtani, Saad S. Alqahatni, Taha Alqahtani, Ali Alamri, Nikhil Agrawal   +9 more
wiley   +1 more source

Anisotropic Microgels by Supramolecular Assembly and Precipitation Polymerization of Pyrazole‐Modified Monomers

Advanced Science, Volume 9, Issue 36, December 28, 2022., 2022
Computer simulations predict supramolecular formation of pyrazole‐modified monomers. Based on the simulations, selected monomers are used in the template‐free and facile upscalable precipitation polymerization to obtain anisotropic microgels (from spherical, raspberry‐like to dumbbell‐like).
Frédéric Grabowski, Vladislav S. Petrovskii, Fabian Fink, Dan Eugen Demco, Sonja Herres‐Pawlis, Igor I. Potemkin, Andrij Pich   +6 more
wiley   +1 more source

Solubility Enhancement of a Poorly Water‐Soluble Drug Using Hydrotropy and Mixed Hydrotropy‐Based Solid Dispersion Techniques

Advances in Pharmacological and Pharmaceutical Sciences, Volume 2022, Issue 1, 2022., 2022
Purpose. The biopharmaceutics classification system places rosuvastatin calcium in class II has a low and fluctuating oral bioavailability. The research focus is to maximize rosuvastatin calcium solubility in water and dissolution rate by employing and combining various hydrotropic agents to make a solid dispersion using solvent evaporation techniques.
Hezha Abdullah Ali, Hunar Kamal Omer, Benedetto Natalini   +2 more
wiley   +1 more source

Ternary Nanoswitches Realized with Multiresponsive PMMA‐b‐PNIPMAM Films in Mixed Water/Acetone Vapor Atmospheres

Advanced Engineering Materials, Volume 23, Issue 11, November 2021., 2021
Ternary nanoswitches are realized using PMMA‐b‐PNIPMAM diblock copolymer thin films. Three distinct film states (off, on, and standby) are successfully prepared by the combination of amphiphilicity and co‐nonsolvency effect. The exposure to N2, pure water vapor, and mixed 90 vol% water/10 vol% acetone vapor switches the films between dried, hydrated ...
Christina Geiger, Julija Reitenbach, Cristiane Henschel, Lucas P. Kreuzer, Tobias Widmann, Peixi Wang, Gaetano Mangiapia, Jean-François Moulin, Christine M. Papadakis, André Laschewsky, Peter Müller-Buschbaum   +10 more
wiley   +1 more source

Microarray Patches: Poking a Hole in the Challenges Faced When Delivering Poorly Soluble Drugs

Advanced Functional Materials, Volume 31, Issue 1, January 4, 2021., 2021
This review explores the delivery of hydrophobic compounds to the skin using microarray patches (MAPs). Initially designed to load low doses of hydrophilic and potent therapeutic agents, MAPs are now increasingly considered a viable strategy for the delivery of therapeutically relevant doses of poorly soluble drugs. This somewhat unexpected application
Alejandro J. Paredes, Peter E. McKenna, Inken K. Ramöller, Yara A. Naser, Fabiana Volpe‐Zanutto, Mingshan Li, M. T. A. Abbate, Li Zhao, Chunyang Zhang, Juhaina M. Abu‐Ershaid, Xianbing Dai, Ryan F. Donnelly   +11 more
wiley   +1 more source

Studies on the Incompatibility between Bulbus fritillariae and Radix aconiti praeparata Based on the P‐gp

Evidence-Based Complementary and Alternative Medicine, Volume 2021, Issue 1, 2021., 2021
Bulbus fritillariae and Radix aconiti praeparata are an incompatible herbal pair in the traditional Chinese medicine theory “eighteen incompatible medicaments,” and they should not be used simultaneously in clinical treatment for safety. This study aimed to investigate the incompatibility mechanism between Bulbus fritillariae and Radix aconiti ...
Weijun Liu, Ling Wei, Yoshikatsu Kanai, Xin He, Min Li   +4 more
wiley   +1 more source

Evaluation of Two Cosolvency Models to Predict Solute Partitioning between Polymers (LDPE) and Water - Ethanol Simulating Solvent Mixtures

, 2022
733751Purpose: Binary water - ethanol mixtures, by mimicking a clinically relevant medium’s polarity-driven extraction strength, facilitate experimental modeling of patient exposure to chemicals which can potentially leach from a plastic material for ...
Egert, T., Langowski, Horst-Christian
core   +1 more source

Solubility prediction of drugs in methanol + water mixtures using minimum number of data points: Comparison of various models

, 2023
This work reports the ability of cosolvency and activity coefficient models in the prediction of drugs solubility in methanol + water mixtures by choosing a minimum number of experimental data point. For this purpose, the available solubility datasets of
Parisa Jafari (5447729), Elaheh Rahimpour (16273199)   +1 more
core   +1 more source