Results 21 to 30 of about 6,892,179 (134)

Measurement and Correlation of the Solubility of Florfenicol in Four Binary Solvent Mixtures from T = (278.15 to 318.15) K

Crystals, 2022
Florfenicol is an excellent antibiotic and is widely used in animal bacterial diseases. However, its poor water solubility leads to various problems, such as poor absorption and bioavailability.
Xinyuan Zhang, Pingping Cui, Qiuxiang Yin, Ling Zhou   +3 more
doaj   +1 more source

Studies on the Incompatibility between Bulbus fritillariae and Radix aconiti praeparata Based on the P‐gp

Evidence-Based Complementary and Alternative Medicine, Volume 2021, Issue 1, 2021., 2021
Bulbus fritillariae and Radix aconiti praeparata are an incompatible herbal pair in the traditional Chinese medicine theory “eighteen incompatible medicaments,” and they should not be used simultaneously in clinical treatment for safety. This study aimed to investigate the incompatibility mechanism between Bulbus fritillariae and Radix aconiti ...
Weijun Liu, Ling Wei, Yoshikatsu Kanai, Xin He, Min Li   +4 more
wiley   +1 more source

Review of the cosolvency models for predicting solubility of drugs in water-cosolvent mixtures

Journal of Pharmacy & Pharmaceutical Sciences, 2008
The cosolvency models presented from 1960 to 2007 were reviewed and their accuracies for correlating and/or predicting the solubility of drugs in water-cosolvent mixtures were discussed.
Abolghasem Jouyban
doaj   +1 more source

Evaluation of Two Cosolvency Models to Predict Solute Partitioning between Polymers (LDPE) and Water - Ethanol Simulating Solvent Mixtures

, 2022
733751Purpose: Binary water - ethanol mixtures, by mimicking a clinically relevant medium’s polarity-driven extraction strength, facilitate experimental modeling of patient exposure to chemicals which can potentially leach from a plastic material for ...
Egert, T., Langowski, Horst-Christian
core   +1 more source

Solubility prediction of drugs in methanol + water mixtures using minimum number of data points: Comparison of various models

, 2023
This work reports the ability of cosolvency and activity coefficient models in the prediction of drugs solubility in methanol + water mixtures by choosing a minimum number of experimental data point. For this purpose, the available solubility datasets of
Parisa Jafari (5447729), Elaheh Rahimpour (16273199)   +1 more
core   +1 more source

Review of the Cosolvency Models for Predicting Drug Solubility in Solvent Mixtures: An Update

Journal of Pharmacy & Pharmaceutical Sciences, 2019
The cosolvency models frequently used in solubility data modeling of drugs in mixed solvents were reviewed and their accuracies for calculating the solubility of solutes were briefly discussed.
Abolghasem Jouyban
doaj   +1 more source

Solubility of Sildenafil Citrate in Polyethylene Glycol 200 + Water Mixtures at 293.2-313.2 K [PDF]

Pharmaceutical Sciences
Background: In the current investigation, the evaluation of model congruence alongside experimental determinations of the solid-liquid phase boundary concerning sildenafil citrate within aqueous binary blends of polyethylene glycol 200 has been conducted.
Homa Rezaei, Abolghasem Jouyban
doaj   +1 more source

Solubility of Different Polymorphs of Drugs in Mono- and Mixed-Solvents at Various Temperatures [PDF]

Pharmaceutical Sciences
Background: Solubility of drugs is an important issue in pharmaceutical industry and the solubility of polymorphs play a critical role in dealing with the solubility issue.
Abolghasem Jouyban
doaj   +1 more source

New phase phenomena in ternary systems at high pressures - Cosolvency and miscibility windows up to 100 MPay [PDF]

, 2020
For selected systems CO 2 + alkan-1-ol + alkane, new high-pressure phase phenomena have been found. Isobaric cosolvency effects and isothermal miscibility windows are presented phenomenologically and numerically. Additionally, rules for the occurrence of
Arndt L Scheidgenz, Gerhard M Schneider
core  

Solubility of Deferiprone in Non-Aqueous Mixtures of Polyethylene Glycol 400 and 1-Propanol at 293.2–323.2 K

Liquids
Utilizing the shake-flask technique under atmospheric pressure (101 kPa) within the temperature range of 293.2 to 313.2 K, the experimental solubility and density values of deferiprone were determined in binary mixtures of polyethylene glycol 400 and 1 ...
Homa Rezaei, Abolghasem Jouyban
doaj   +1 more source