Results 41 to 50 of about 275 (175)

Evaluation of Solid–Liquid Equilibria for Ternary Pharmaceutical Compound + Water + Cyclodextrin or Its Derivative Systems with Wilson and Modified Chrastil Models

, 2023
The solid–liquid equilibria (SLE) of ternary mixtures of pharmaceutical compound + water + solid cosolvent cyclodextrin (CD) were calculated using the Wilson equation as the activity coefficient model, to evaluate the cosolvency of CD for poorly water ...
Kiyofumi Kurihara, Hiroyuki Matsuda, Katsumi Tochigi   +2 more
core   +1 more source

Solubility of Deferiprone in Non-Aqueous Mixtures of Polyethylene Glycol 400 and 1-Propanol at 293.2–323.2 K

Liquids
Utilizing the shake-flask technique under atmospheric pressure (101 kPa) within the temperature range of 293.2 to 313.2 K, the experimental solubility and density values of deferiprone were determined in binary mixtures of polyethylene glycol 400 and 1 ...
Homa Rezaei, Abolghasem Jouyban
doaj   +1 more source

A Comprehensive Review on Cyclodextrin‐Based Carriers for Delivery of Chemotherapeutic Cytotoxic Anticancer Drugs

BioMed Research International, Volume 2015, Issue 1, 2015., 2015
Most of the cytotoxic chemotherapeutic agents have poor aqueous solubility. These molecules are associated with poor physicochemical and biopharmaceutical properties, which makes the formulation difficult. An important approach in this regard is the use of combination of cyclodextrin and nanotechnology in delivery system.
Bina Gidwani, Amber Vyas, Spyros S. Skandalis   +2 more
wiley   +1 more source

Solubility Measurement and Thermodynamic Study of Clotrimazole in Aqueous Mixtures of N-Methyl-2-Pyrrolidone at Various Temperatures: Study of Clotrimazole Solubility

, 2023
Clotrimazole is a broad-spectrum antifungal drug within the imidazole group that can potentially disrupt fungal cell ergosterol synthesis. It is a lipophilic molecule with a slow dissolution rate in water and poor aqueous solubility.
Zhao , Hongkun, Rahimpour, Elaheh, Jouyban , Abolghasem, Rezaei , Homa   +3 more
core   +1 more source

Development of Orodispersible Tablets of Candesartan Cilexetil‐β‐cyclodextrin Complex

Journal of Pharmaceutics, Volume 2013, Issue 1, 2013., 2013
The aim of this study was to investigate the use of inclusion complexation technique employing β‐cyclodextrin in improving the dissolution profile of candesartan cilexetil, a BCS class‐II drug, and to formulate the inclusion complex into orodispersible tablets.
Maddukuri Sravya, Rajamanickam Deveswaran, Srinivasan Bharath, Basappa Veerbadraiah Basavaraj, Varadharajan Madhavan, Giuseppina De Simone   +5 more
wiley   +1 more source

A Study on Solubilization of Poorly Soluble Drugs by Cyclodextrins and Micelles: Complexation and Binding Characteristics of Sulfamethoxazole and Trimethoprim

The Scientific World Journal, Volume 2012, Issue 1, 2012., 2012
The present study is focused on the characterization of solubilization of poorly soluble drugs, that is, sulfamethoxazole (SMX) and trimethoprim (TMP) by cyclodextrins (α‐, β‐, and γ‐CDs) and anionic surfactant sodium dodecyl sulfate (SDS). The phase solubility diagrams drawn from UV spectral measurements are of the AL type and indicate an enhancement ...
Sinem Göktürk, Elif Çalışkan, R. Yeşim Talman, Umran Var, Yadavalli Venkata Nageswar, Parvin Zakeri-Milani   +5 more
wiley   +1 more source

Adaptive Elastin‐Like Hydrogel with Unidirectional and Controllable Anisotropic Actuation for Soft Robotics and Tissue Engineering

Advanced Materials Technologies, Volume 10, Issue 17, September 4, 2025.
Fiber‐reinforced elastin‐like tubular scaffolds are engineered to achieve anisotropic and reversible actuation under external stimuli. By adjusting fiber's angle, actuation behavior is finely tuned, enabling distinct actuation responses, even within different regions of the same scaffold.
Federica Sallustio, Amanda Schmidt, Ikram El Maachi, Alexander Greenhalgh, Martin Frydrych, Stefan Jockenhoevel, José Carlos Rodríguez‐Cabello, Alicia Fernández‐Colino   +7 more
wiley   +1 more source

Drug Solubility: Importance and Enhancement Techniques

International Scholarly Research Notices, Volume 2012, Issue 1, 2012., 2012
Solubility, the phenomenon of dissolution of solute in solvent to give a homogenous system, is one of the important parameters to achieve desired concentration of drug in systemic circulation for desired (anticipated) pharmacological response. Low aqueous solubility is the major problem encountered with formulation development of new chemical entities ...
Ketan T. Savjani, Anuradha K. Gajjar, Jignasa K. Savjani, G. Aktay, Y.-Z. Du, J. Torrado   +5 more
wiley   +1 more source

Nonadditive CO2 Uptake of Type II Porous Liquids Based on Imine Cages

ChemPhysChem, Volume 26, Issue 12, June 23, 2025.
Type II porous liquids based on porous imine cages (CC13/CC19) show non‐additive CO2 uptake, surpassing ideal volume additivity predictions. Experiments and simulations reveal enhanced gas absorption, with CO2 partitioning into cage pores and solvent.
Lu Lu, Chao‐Wen Chang, Stephen Schuyten, Ankana Roy, David S. Sholl, Ryan P. Lively   +5 more
wiley   +1 more source

Solubility Enhancement of Etoricoxib by Cosolvency Approach

International Scholarly Research Notices, Volume 2012, Issue 1, 2012., 2012
The purpose of the present study was to examine and compare the cosolvency using three different cosolvents, namely PEG 400, PG, and glycerin on the aqueous solubility enhancement of a poorly aqueous soluble drug, etoricoxib, since solubilization of nonpolar drugs constitutes one of the important tasks in the formulation design of liquid dosage forms ...
Amit Kumar Nayak, Prachi Prava Panigrahi, A. Dkhissi, L. K. Shrestha, N. A. Vodolazkaya   +4 more
wiley   +1 more source