Results 51 to 60 of about 5,736 (192)

MRI multicentre prospective survey in thalassaemia major patients treated with deferasirox versus deferiprone and desferrioxamine

, 2018
We prospectively assessed the efficacy of deferasirox versus deferiprone or desferrioxamine as monotherapy in thalassaemia major (TM) patients by magnetic resonance imaging (MRI).
D'Ascola D. G., Restaino G., Meloni A., Lisi R., Mangione M., Pepe A., Cuccia L., Pistoia L., Gamberini M. R., Ricchi P., Righi R., Rosso R., Allo M., Positano V., Spasiano A.   +14 more
core   +1 more source

Deferiprone attenuates neuropathology and improves outcome following traumatic brain injury

, 2023
BACKGROUND AND PURPOSE: Traumatic brain injury (TBI) remains a leading cause of mortality and morbidity in young adults. The role of iron in potentiating neurodegeneration following TBI has gained recent interest as iron deposition has been detected in ...
Rao, SS, Miles, LQ, Juan, SMA, Adlard, PA, Truong, PH, Daglas, M   +5 more
core   +1 more source

Treatment response of deferiprone in infratentorial superficial siderosis : a systematic review [PDF]

, 2021
Superficial siderosis describes haemosiderin deposition on the surface of the brain. When present on infratentorial structures, it can cause ataxia, sensorineural hearing loss and pyramidal signs. There is no proven treatment and patients experience slow
Flores Martin, A., Hadjivassiliou, M., Hoggard, N., Shanmugarajah, P.   +3 more
core   +1 more source

Effect of deferiprone or deferoxamine on right ventricular function in thalassemia major patients with myocardial iron overload

Journal of Cardiovascular Magnetic Resonance, 2011
Background Thalassaemia major (TM) patients need regular blood transfusions that lead to accumulation of iron and death from heart failure. Deferiprone has been reported to be superior to deferoxamine for the removal of cardiac iron and improvement in ...
Gotsis Efstathios D, Aessopos Athanassios, Piga Antonio, Ladis Vasili, Karagiorga Markissia, Berdoukas Vasili, Alam Mohammed H, Carpenter John, Alpendurada Francisco, Smith Gillian C, Tanner Mark A, Westwood Mark A, Galanello Renzo, Roughton Michael, Pennell Dudley J   +14 more
doaj   +1 more source

Exploring and Targeting the Connection of Iron and Copper Homeostasis to Neurodegenerative Diseases

MedComm, Volume 7, Issue 6, June 2026.
Iron and copper dyshomeostasis, along with their interactions with key intrinsically disordered proteins (e.g., Aβ, tau, α‐synuclein) have a strong implication in the onset and progression of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Prion diseases (PrDs), Huntington's disease (HD), Wilson's disease (WD),
Xin Liu, Lin Jia, Kerong Wu, Mo Chen, Jichao Sun, Chuanbin Yang, Chengchao Xu, Jie Sun, Jigang Wang, Lingyun Dai   +9 more
wiley   +1 more source

Redox Regulation and Oxidative Stress in Health and Disease: Mechanisms and Therapeutic Targeting

MedComm – Future Medicine, Volume 5, Issue 2, June 2026.
Reactive species serve crucial roles which are tightly regulated in both physiological as well as disease states. At physiological levels, these species are integral to redox signaling, while uncontrolled redox promotes disease pathology. This review examines the dysregulation of these processes.
Mohammad Hossein Azadi, Azadeh Niknejad, Elaheh Amini   +2 more
wiley   +1 more source

Deferiprone increases endothelial nitric oxide synthase phosphorylation and nitric oxide production

, 2018
Iron chelation can improve endothelial function. However, effect on endothelial function of deferiprone has not been reported. We hypothesized deferiprone could promote nitric oxide (NO) production in endothelial cells.
Rattanawonsakul , Krit, Vivithanaporn, Pornpun, Thanaporn Sriwantana, Nathawut Sibmooh, Sibmooh, Nathawut, Sirada Srihirun, Pornpun Vivithanaporn, Krit Rattanawonsakul, Paiboonsukwong, Kittiphong, Sriwantana, Thanaporn, Kittiphong Paiboonsukwong, Srihirun, Sirada   +11 more
core   +1 more source

Design and development of metal-organic framework-based nanocomposite hydrogels for quantification of deferiprone in exhaled breath condensate

BMC Chemistry
In this study, a novel fluorescence nanoprobe based on Materials of Institute Lavoisier (MIL-101) metal-organic frameworks embedding into the agarose hydrogel is fabricated using a hydrothermal technique.
Reza Moharami, Zahra Karimzadeh, Jafar Soleymani, Vahid Jouyban-Gharamaleki, Maryam Khoubnasabjafari, Elaheh Rahimpour, Abolghasem Jouyban   +6 more
doaj   +1 more source

Chelation Therapy with Oral Solution of Deferiprone in Transfusional Iron-Overloaded Children with Hemoglobinopathies

Anemia, 2013
Iron overload in hemoglobinopathies is secondary to blood transfusions, chronic hemolysis, and increased iron absorption and leads to tissue injury requiring the early use of chelating agents.
Alexandros Makis, Nikolaos Chaliasos, Sapfo Alfantaki, Paraskevi Karagouni, Antigone Siamopoulou   +4 more
doaj   +1 more source

ALT elevations correlating with deferiprone chelation.

, 2019
(A) Patient #34, (B) Patient #1, (C) Patient #19 (datafile). Normal ALT
Brenda L. Gallie (249953), Nancy F. Olivieri (6407168), Amir Sabouhanian (6407171)   +2 more
core   +1 more source