Results 131 to 140 of about 491,152 (275)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Comparison and Analysis of Antibiotic Consumption in Two Italian Hospital Settings in Relation to the Fight of Antimicrobial Resistance

Pharmaceuticals
Introduction: The emergence and spread of drug-resistant pathogens due to the improper use of antibiotics have become increasingly apparent in recent years.
Francesco Ferrara, Roberta Pasquinucci, Maurizio Capuozzo, Giacomo Polito, Gabriele Bagaglini, Marcello Vaccaro, Adriana Coluccia, Roberto Langella, Ugo Trama, Eduardo Nava, Andrea Zovi   +10 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Asthma control in patients receiving inhaled corticosteroid and long-acting beta2-agonist fixed combinations. A real-life study comparing dry powder inhalers and a pressurized metered dose inhaler extrafine formulation

, 2011
Background Although patients have more problems using metered dose inhalers, clinical comparisons suggest they provide similar control to dry powder inhalers.
Eszes, Noemi, Gabriele Nicolini, Chrystyn, Henry, Eszes Noemi, György Losonczy, Noemi Eszes, Henry Chrystyn, Müller, Veronika, Gabriella Gálffy, Chrystyn Henry, Nicolini Gabriele, Gálffy Gabriella, Andrea Bizzi, Lilla Tamási, Bizzi Andrea, Tamási Lilla, Gálffy, Gabriella, Tamási, Lilla, Müller Veronika, Losonczy, György, Nicolini, Gabriele, Bizzi, Andrea, Veronika Müller, Losonczy György   +23 more
core   +1 more source

Cross-resistance to antibiotics of Escherichia coli in the inpatient installation of general regional hospital “X” Bali, Indonesia

Pharmaciana
Escherichia coli (E. coli) is a critical-priority group of MDR bacteria and its spread can occur in hospital inpatient settings. Several studies showed that antibiotics consumption for inpatients can cause E.
I Putu Yudistira Mahaputra, Dwi Arymbhi Sanjaya, Herleeyana Meriyani, Rr Asih Juanita, Nyoman Budiartha Siada, Made Gek Adisti Kamalia, Ketut Agus Adrianta, Lusy Noviani   +7 more
doaj   +1 more source

Prognostic Model of Microbial Resistance Based on the Relationship between Antibiotic Resistance and Consumption [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2016
Acquired bacterial resistance is one of the leading causes of morbidity and mortality attributed to infectious diseases. Simulations may provide opportunity to predict further spread of resistance and, to some extent, manage it.
Arepeva M.A., Kolbin A.S., Sidorenko S.V., Kurylyov A.A., Balykina Yu.E., Mukhina N.V., Spiridonova A.A.   +6 more
doaj  

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Odds Ratio (OR) and 95% Confidence Intervals (CI) of MNLIHD Associated with Annual Mean Daily Defined Dose (DDD) Use of Amiodarone.

, 2015
†Adjusted for statins, anti-diabetics, NSAIDS, antiarrhythmic drugs of propafenone, quinidine, comorbidities of diabetes, chronic liver disease, cirrhosis, HBV infection, HCV infection, and alcoholism ...
Dong-Zong Hung (13171), Chia-Hung Kao (173343), Wei-Chih Ma (683882), Yun-Ping Lim (683880), Yen-Ning Lin (683881), Wei-Cheng Chen (9433), Cheng-Li Lin (388859)   +6 more
core   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

THE USE OF HORMONES DURING THE PERIMENOPAUSAL PERIOD IN SLOVENIA

Zdravniški Vestnik, 2003
Background. We want to collect data on the use of hormone therapy (HT) in perimenopausal women in Slovenia. These data were to serve as the basis for evaluation of the most frequently prescribed HT, and of the distribution of prescriptions by Slovene ...
Damir Franić, Jurij Fürst
doaj