Results 111 to 120 of about 491,152 (275)

Assigning defined daily doses animal: a European multi-country experience for antimicrobial products authorized for usage in pigs [PDF]

, 2015
Objectives: To establish a consensus defined daily dose animal (DDDA) for each active substance (AS) and administration route for porcine veterinary antimicrobial products authorized in four European countries, thus allowing cross-country quantification ...
Collineau, L, Postma, MerelDI080019990798688020009046610000-0003-3628-20142D83D8E0-F0EE-11E1-A9DE-61C894A0A6B4, On Behalf of The Minapig Consortium, ., Loesken, S, Dewulf, J, Staerk, K D C, Postma, Merel, Lösken, Svenja, Postma, M, Dewulf, Jeroen, Sjölund, Marie, Collineau, Lucie, Dewulf, JeroenCA05DI080019920941518010012560070000-0001-9843-5990F57DE986-F0ED-11E1-A9DE-61C894A0A6B4, Sjoelund, M, Stärk, Katharina D. C., Stärk, Katharina DC   +15 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Comparison of antimicrobial usage estimated using records-based software with estimates based on an inventory of drug packaging waste

Journal of Dairy Science
: Measurement of antimicrobial usage (AMU) on dairy farms is an important aspect of antimicrobial stewardship and has been performed using a variety of methods. The objectives of this observational study were to compare AMU estimated using data extracted
L.C.B. Juliano, Z. Rodriguez, G.G. Habing, R. Portillo-Gonzalez, P.L. Ruegg   +4 more
doaj   +1 more source

Estimating antibiotics consumption in a tertiary care hospital in Islamabad using a WHO's defined daily dose methodology. [PDF]

Antimicrob Resist Infect Control, 2023
Jabeen N, Ullah W, Khalid J, Samad Z.
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Assigning Defined Daily Doses Animal: a European multi-country experience

, 2013
In order to be able to compare antimicrobial usage data between countries with a uniform quantification method a Defined Daily Dose Animal (DDDA) per active substance was defined.
Marie Sjölund, Jeroen Dewulf, Merel Postma, Loesken, Svenja, Svenja Loesken, Postma, Merel, Dewulf, Jeroen, Sjölund, Marie, Collineau, Lucie, Lucie Collineau, Elisabeth Okholm Nielsen, Okholm Nielsen, Elisabeth, Stärk, Katharina, Katharina D. C. Stärk   +13 more
core   +1 more source

Calculating daily dose in the Observational Medical Outcomes Partnership Common Data Model [PDF]

Purpose: We aimed to develop a standardized method to calculate daily dose (i.e., the amount of drug a patient was exposed to per day) of any drug on a global scale using only drug information of typical observational data in the Observational Medical ...
Oja, Marek, Mayer, Miguel Ángel, 1960-, Oja, M, Mayer, Miguel Angel, de Ridder, Maria, Gorbachev, A, Gorbachev, Artem, Jödicke, AM, Català, Martí, Ramírez-Anguita, JM, Prieto Alhambra, Daniel, Bellas, L, Reich, C, Bonadt, Klaus, Kolde, R, de Ridder, Maria; id_orcid, Mosseveld, Mees, Bonadt, K, Mayer, MA, Kolde, Raivo, Gratton, J, Reich, Christian, de Ridder, M, Reich, Chistian, Prieto-Alhambra, Daniel, Vojinovic, Dina, Ramírez Anguita, Juan Manuel, Jödicke, Annika M., Burkard, Theresa, Burkard, T, Machín, AL, Gratton, Jasmine, Seager, Sarah, Mosseveld, Mees; id_orcid, Mosseveld, M, Vojinovic, D, Seager, S, López-Güell, K, Ramírez-Anguita, Juan Manuel, Català, M, Bellas, Lucía, Burn, E, Machín, Angela Leis, Leis Machín, Angela 1974-, López-Güell, Kim, Burn, Edward   +45 more
core   +2 more sources

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source