Results 101 to 110 of about 6,869,765 (282)

Average treatment incidences (min-max) based on the animal defined daily dose (ADD; TI_ADD) and the prescribed daily dose (UDD; TI_UDD) of the orally administered antimicrobial drugs in the veal herds (entire study period).

, 2016
Average treatment incidences (min-max) based on the animal defined daily dose (ADD; TIADD) and the prescribed daily dose (UDD; TIUDD) of the orally administered antimicrobial drugs in the veal herds (entire study period).
Benedicte Callens (2179862), Jeroen Dewulf (2179868), Freddy Haesebrouck (149708), Geert Opsomer (2179872), Dominiek Maes (2179870), Aart de Kruif (2179874), Bart Pardon (2179864), Mia Vanrobaeys (2179866), Boudewijn Catry (416579)   +8 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

The appropriateness of initial intravenous empirical antibiotic consumption guided by digital antimicrobial stewardship tool: a correlation with the usage of antibiotics from the access and watch groups in ten Indonesian hospitals

Frontiers in Digital Health
BackgroundRASPRO Indonesia Study Group for Antimicrobial Stewardship & Resistance has developed a digital antimicrobial stewardship (ASP) tool known as the e-RASPRO, which may provide a guideline for clinical decision on antibiotic prescribing for ...
Ronald Irwanto Natadidjaja, Ronald Irwanto Natadidjaja, Ronald Irwanto Natadidjaja, Widyawati Lekok, Widyawati Lekok, Triyoko Septio Marja, Hadianti Adlani, Hadianti Adlani, Hadianti Adlani, Aziza Ariyani, Sri Mulyani, Siti Rahmah, Raymond Adianto, Yenny Yenny, Yenny Yenny, Meutia Atika Faradilla, Meutia Atika Faradilla, Jihan Samira, Jihan Samira   +18 more
doaj   +1 more source

Antimicrobial Drug Consumption on Swiss Pig Farms: A Comparison of Swiss and European Defined Daily and Course Doses in the Field

Frontiers in Veterinary Science, 2019
Defined Daily Doses (DDD) and Defined Course Doses (DCD) have been established in both human and veterinary medicine in order to standardize the measurement of treatments in a population.
Thomas Echtermann, Cedric Muentener, Xaver Sidler, Dolf Kümmerlen   +3 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

The defined daily dose per 1,000 patients per day (DDDs/1,000 patients/day) of study drugs in Korea in 2010.

, 2015
The defined daily dose per 1,000 patients per day (DDDs/1,000 patients/day) of study drugs in Korea in 2010.
Nam-Kyong Choi (504595), Jungmee Kim (747693), Hong-Ji Song (747694), Byung-Joo Park (504596), Ju-Young Shin (504594), Joongyub Lee (504592)   +5 more
core   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source