Results 101 to 110 of about 858,476 (293)

Automated Home Oxygen Delivery for Patients with COPD and Respiratory Failure: A New Approach [PDF]

, 2020
Long-term oxygen therapy (LTOT) has become standard care for the treatment of patients with chronic obstructive pulmonary disease (COPD) and other severe hypoxemic lung diseases.
Lara Doña, Alejandro, León Jiménez, Antonio, Muñoz Zara, Pilar, Sánchez Morillo, Daniel   +3 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Changes in the defined daily dose; CYP2D6/CYP3A metabolism as an indicator for dose-setting problems

European Journal of Clinical Pharmacology, 2005
Interindividual variability is common at all stages of drug absorption, distribution, pharmacodynamics, metabolism and elimination. In this study, we focused on two enzymes involved in phase-I drug metabolism as markers of pharmacological variability: the CYP3A and CYP2D6 subsystems of cytochrome P450. The main aim of our study was to determine whether
Stolk, P., Heerdink, E.R., Leufkens, H.G.M.   +2 more
openaire   +4 more sources

A phase 1 trial dose-escalation study of tipifarnib on a week-on, week-off schedule in relapsed, refractory or high-risk myeloid leukemia. [PDF]

, 2011
Inhibition of farnesyltransferase (FT) activity has been associated with in vitro and in vivo anti-leukemia activity. We report the results of a phase 1 dose-escalation study of tipifarnib, an oral FT inhibitor, in patients with relapsed, refractory or ...
Forman, SJ, Frankel, P, Karanes, C, Kirschbaum, MH, Newman, EM, O'Donnell, MR, Popplewell, L, Pulone, B, Rincon, A, Stein, AS, Synold, T, Tuscano, J, Wright, J, Zain, JM   +13 more
core  

Dispelling urban myths about default uncertainty factors in chemical risk assessment - Sufficient protection against mixture effects? [PDF]

, 2013
© 2013 Martin et al.; licensee BioMed Central LtdThis article has been made available through the Brunel Open Access Publishing Fund.Assessing the detrimental health effects of chemicals requires the extrapolation of experimental data in animals to human
A Kortenkamp, A Kortenkamp, A Rane, AG Renwick, AG Renwick, AG Renwick, AG Renwick, AJ Lehman, Andreas Kortenkamp, BD Naumann, BD Naumann, BGH Bokkers, CI Bliss, CM Thompson, CS Weil, D Hattis, D Hattis, D Hattis, D Hattis, D Hattis, D Hattis, D Hattis, D Hattis, Danish EPA, DL Glaubiger, DM Sheehan, DW Gaylor, ECETOC, ECETOC, ECHA, EJ Bigwood, EJ Calabrese, EJ Calabrese, EJ Calabrese, EJ Calabrese, EJ Freireich, ER Homan, European Commission, European Community, F Kalberlah, F Kalberlah, F Kalberlah, G Charnley, G Ginsberg, G Ginsberg, G Ginsberg, G Ginsberg, G Vettorazzi, GA Skowronski, GN Krasovskii, GWM Petersvolleberg, H Boxenbaum, H Carlson-Lynch, HA Tilson, HJ Clewell, HJ Clewell, IPCS, IPCS, IPCS, IPCS, IPCS, IWF Davidson, JC Swartout, JECFA, JEFCA, JEFCA, JL Dorne, JLCM Dorne, K Schneider, K Schneider, K Schneider, K Walton, K Walton, K Walton, K Watanabe, KC Silverman, KEMI, KS Crump, KS Crump, LT Haber, M Dourson, M Faust, M Rennen, M Scholze, ME Meek, ML Dourson, ML Dourson, ML Dourson, National Research Council, National Research Council, Olwenn V Martin, P Griem, PR Gentry, PS Price, R Cooke, R Goble, R Hasegawa, R Hasegawa, R Kroes, R Scheuplein, R Truhaut, RH White, RL Dixon, SC Lewis, SCHER/SCENIHR/SCCS, Scholze Martin, SJS Baird, T Backhaus, TG Vermeire, TG Vermeire, USEPA, W Slob, W Slob, WJJ Hayes   +113 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Logistic Stewardship: Supporting Antimicrobial Stewardship Programs Based on Antibiotics Goods Flow

Antibiotics
Background/Objectives: Antimicrobial resistance is a global threat to safe health care, and a reduction in antibiotic consumption seems to be an appropriate preventive measure.
Bianca Leistner, Dominic Rauschning, Ralf Matthias Hagen, Franziska Srečec, Nico Tom Mutters, Ruth Weppler, Christina Mutschnik, Manuel Döhla   +7 more
doaj   +1 more source

A Bayesian time-to-event pharmacokinetic model for sequential phase I dose-escalation trials with multiple schedules

, 2020
Phase I dose-escalation trials constitute the first step in investigating the safety of potentially promising drugs in humans. Conventional methods for phase I dose-escalation trials are based on a single treatment schedule only.
Friede, Tim, Günhan, Burak Kürsad, Seroutou, Abdelkader, Weber, Sebastian   +3 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Addition to inhaled corticosteroids of long-acting beta2-agonists versus anti-leukotrienes for chronic asthma [PDF]

, 2011
Asthma patients who continue to experience symptoms despite being on regular inhaled corticosteroids (ICS) represent a management challenge. Long-acting beta2-agonists (LABA) or anti-leukotrienes (LTRA) are two treatment options that could be considered ...
Adams, Adinoff, Altman, Anonymous, Anonymous, Anonymous, Baraniuk, Barnes, Bateman, Bateman, Becker, Bergmann, Bjermer, Bjermer, Bjermer, Bleecker, Borker, Boulet, Bousquet, Brabson, Buchvald, Buchvald, Buhl, Busse, Caffey, Calhoun, Calhoun, Cash, Cates, Ceylan, Chopra, Chuchalin, Covar, Currie, Currie, Currie, Davies, Davis, Deeks, Dekhuijzen, Delaronde, Dempsey, Deykin, Dicpinigaitis, Donohue, Dorinsky, Dorinsky, Dorinsky, Dorinsky, Ducharme, Ducharme, Ducharme, Ducharme, Dunn, Edelman, Edin, Egger, Eliraz, Eliraz, Ernst, Everden, Fish, Fish, Gabrijelcic, Georgitis, Giannini, Gold, Gold, Green, Green, Green, Grosclaude, Grzelewska-Rzymowska, Gupta, Havlucu, Hendeles, Higgins, Higgins, Horwitz, Houghton, Ilowite, Inoue, Jarvis, Jarvis, Jenkins, Johnson, Jonsson, Kalberg, Kalberg, Kanniess, Kanniess, Karaman, Kardos, Keith, Kemp, Keonig, Kerwin, Knobil, Knorr, Koenig, Kohrogi, Krawiec, Larsen, Laviolette, Lazarus, Lee, Lee, Lee, Lee, Leflein, Leibman, Leibman, Lemanske, Lipworth, Lipworth, Liu, Lotvall, Lougheed, Maspero, Maspero, Maspero, McCarthy, McCarthy, Meltzer, Miraglia del Giudice, Mitchell, Molitor, Naedele-Risha, Nathan, Nathan, Nathan, Nathan, Nathan, Nelson, Nelson, Nelson, Nelson, Nelson, Ni Chroinin, Ni Chroinin, Nsouli, O'Connor, O'Sullivan, Ohbayashi, Ohbayashi, Ollendorf, Oppenheimer, Orgega-Cisneros, Paterson, Pavord, Pearlman, Perera, Perez, Peroni, Peroni, Petermann, Peters, Pieters, Pieters, Plaza, Polos, Powell, Price, Ram, Reddel, Rees, Riccioni, Rickard, Rickard, Ringdal, Ringdal, Rosenhall, Salpeter, Serrier, Sheth, Sims, Sims, Sims, Smith, Sorkness, Stanford, Stelmach, Stelmach, Stelmach, Stelmach, Stelmach, Stelmach, Stempel, Stempel, Stevenson, Storms, Storms, Terzano, Thien, Tolley, Vaquerizo, Volovitz, Walters, Warner, Wasserman, Wenzel, Wilson, Wilson, Wilson, Wytrychowski, Yurdakul, Zarkovic, Zimmerman   +207 more
core   +1 more source