Results 91 to 100 of about 6,869,765 (282)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
AMBITION-cm : intermittent high dose AmBisome on a high dose fluconazole backbone for cryptococcal meningitis induction therapy in sub-Saharan Africa : study protocol for a randomized controlled trial [PDF]
, 2015 Cryptococcal meningitis (CM) is a leading cause of mortality among HIV-infected individuals in Africa. Poor outcomes from conventional antifungal therapies, unavailability of flucytosine, and difficulties administering 14 days of amphotericin B are key ...
Leeme, Tshepo +50 more
core +2 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
All-cause dementia by A) use and B) defined daily dose (DDD) of proton pump inhibitors (PPIs).
, 2017 All-cause dementia by A) use and B) defined daily dose (DDD) of proton pump inhibitors (PPIs).
Chen-Yu Chien (3406031) +6 more
core +1 more source
Health effects of daily airborne particle dose in children : direct association between personal dose and respiratory health effects [PDF]
, 2013 Air pollution is a widespread health problem associated with respiratory symptoms. Continuous exposure monitoring was performed to estimate alveolar and tracheobronchial dose, measured as deposited surface area, for 103 children and to evaluate the long ...
Morawska, Lidia +3 more
core +1 more source
, 2021 : ANALYSIS OF THE USE OF ANTIBIOTICS IN THE SURGERY ROOM OF THE REGIONAL GENERAL HOSPITAL H. ABDUL MOLOEK PROVINCE LAMPUNG WITH DEFINED DAILY DOSE METHOD OF JANUARY-MARCHPERIOD 2018Background: Antibiotics are chemicals produced by fungi and bacteria ...
Adityadarma, Galih +2 more
core +1 more source
Utilization Pattern of Antibiotics in Different Wards of Sari Imam Khomeini Teaching Hospital
Journal of Mazandaran University of Medical Sciences, 2007 Background and Purpose: Due to an increase in cases of irrational drug prescription and it's health and economic consequences, evaluation of the rational use of drugs seemed necessary.
M.A. Ebrahimzadeh, Ph.D. +6 more
doaj
Trends in major opioid analgesic consumption in Taiwan, 2002–2014
Journal of the Formosan Medical Association, 2017 Background/Purpose: According to WHO guideline, the consumption of opioids is an important sign of national progress in cancer pain relief. However, precise data on the consumption of opioid analgesics consumption in Taiwan has not been published.
Kai-Hsiang Kang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
, 2017 The number of antihypertensive drug classes cannot accurately reflect the total consumption of antihypertensive drugs used to control blood pressure. The defined daily dose has been adopted to permit consumption analysis of many prescribed drugs. The aim
Tomoaki Tanaka, Tomoaki Tanaka +9 more
core