Results 91 to 100 of about 491,152 (275)

The defined daily dose per 1,000 patients per day (DDDs/1,000 patients/day) of study drugs in Korea in 2010.

, 2015
The defined daily dose per 1,000 patients per day (DDDs/1,000 patients/day) of study drugs in Korea in 2010.
Nam-Kyong Choi (504595), Jungmee Kim (747693), Hong-Ji Song (747694), Byung-Joo Park (504596), Ju-Young Shin (504594), Joongyub Lee (504592)   +5 more
core   +1 more source

Logistic Stewardship: Supporting Antimicrobial Stewardship Programs Based on Antibiotics Goods Flow

Antibiotics
Background/Objectives: Antimicrobial resistance is a global threat to safe health care, and a reduction in antibiotic consumption seems to be an appropriate preventive measure.
Bianca Leistner, Dominic Rauschning, Ralf Matthias Hagen, Franziska Srečec, Nico Tom Mutters, Ruth Weppler, Christina Mutschnik, Manuel Döhla   +7 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Trends in major opioid analgesic consumption in Taiwan, 2002–2014

Journal of the Formosan Medical Association, 2017
Background/Purpose: According to WHO guideline, the consumption of opioids is an important sign of national progress in cancer pain relief. However, precise data on the consumption of opioid analgesics consumption in Taiwan has not been published.
Kai-Hsiang Kang, Li-Fen Kuo, I-Chen Cheng, Chih-Shiuh Chang, Wen-Ing Tsay   +4 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Utilization Pattern of Antibiotics in Different Wards of Sari Imam Khomeini Teaching Hospital

Journal of Mazandaran University of Medical Sciences, 2007
Background and Purpose: Due to an increase in cases of irrational drug prescription and it's health and economic consequences, evaluation of the rational use of drugs seemed necessary.
M.A. Ebrahimzadeh, Ph.D., F. Ansari, Pharm.D, A. Ramezani, Pharm.D., M. Shokrzadeh, Ph.D, B. Shaabankhani, M.Sc., S.S. Saeedi Saravi, Z. Bagherzadegan, Pharm.D.   +6 more
doaj  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Profil Penggunaan Antibiotik Pada Pasien Pediatri Rujukan Berdasarkan Sistem Defined Daily Dose (DDD) [PDF]

, 2020
Tujuan dari penelitian ini adalah untuk mengetahui profil penggunaan antibiotik pada pasien pediatri yang dirujuk ke RSPAL Dr. Ramelan selama bulan April hingga Juli 2019. Penelitian ini merupakan penelitian observasional deskriptif yang dilakukan secara
Widyati, Widyati, Upa , Nurul Fatmawati Pua, Widiaty, Widyati, Pua Upa, Nurul Fatmawati, Prasetyadi, Frans O.H.   +4 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Assessment of postoperative changes in antihypertensive drug consumption in patients with primary aldosteronism using the defined daily dose

, 2017
The number of antihypertensive drug classes cannot accurately reflect the total consumption of antihypertensive drugs used to control blood pressure. The defined daily dose has been adopted to permit consumption analysis of many prescribed drugs. The aim
Tomoaki Tanaka, Tomoaki Tanaka, Yukio Naya, Yukio Naya, Takashi Imamoto, Takashi Imamoto, Naoto Kamiya, Naoto Kamiya, Takanobu Utsumi, Takanobu Utsumi, Hidekazu Nagano, Hidekazu Nagano, Koji Kawamura, Koji Kawamura, Naoki Nihei, Naoki Nihei, Tomohiko Ichikawa, Tomohiko Ichikawa, Hiroyoshi Suzuki, Hiroyoshi Suzuki   +9 more
core