Results 71 to 80 of about 858,476 (293)

Does the Use of Different Indicators to Benchmark Antimicrobial Use Affect Farm Ranking?

Frontiers in Veterinary Science, 2020
The need to reduce antimicrobial use (AMU) in livestock production has led to the establishment of national AMU data collection systems in several countries.
Lorcan O'Neill, Lorcan O'Neill, Maria Rodrigues da Costa, Maria Rodrigues da Costa, Finola Leonard, James Gibbons, Julia Adriana Calderón Díaz, Gerard McCutcheon, Gerard McCutcheon, Edgar García Manzanilla, Edgar García Manzanilla   +10 more
doaj   +1 more source

Phase 1 dose-escalation, pharmacokinetic, and cerebrospinal fluid distribution study of TAK-285, an investigational inhibitor of EGFR and HER2 [PDF]

, 2013
Introduction This phase 1 study assessed safety, maximum tolerated dose (MTD), pharmacokinetics, cerebrospinal fluid (CSF) distribution, and preliminary clinical activity of the receptor tyrosine kinase inhibitor TAK-285.
Dennis Noe, E. Gabriela Chiorean, Edward A. Sausville, Jing-Tao Wu, Karthik Venkatakrishnan, Maria Corvez, Patricia LoRusso, Serap Sankoh   +7 more
core   +1 more source

Preferences of Pediatric Patients and Their Caregivers for Chemotherapy‐Induced Nausea and Vomiting Control Endpoints: A Mixed Methods Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman, Tadi Hondonga, Alison Berry, Caitlin Elgarten, Jason Freedman, Katelyn Oranges, Sara McDonough, Caroline Diorio, L. Lee Dupuis   +8 more
wiley   +1 more source

Antibiotic consumption in Portugal: 2010 and 2011 [PDF]

, 2016
The use of antibiotics has contributed to a marked decrease in morbidity caused by communicable and infec- tious diseases over the past few years. The aim of our study is to evaluate the use of antibiotics in clinic in 2010 and 2011, considering
Filipe Mota, H., Pinho, S., Ramalhinho, Isabel   +2 more
core  

Phase 1 study of sirolimus in combination with oral cyclophosphamide and topotecan in children and young adults with relapsed and refractory solid tumors. [PDF]

, 2016
PurposeTo determine the maximum tolerated dose (MTD), toxicities, and pharmacodynamics effects of sirolimus combined with oral metronomic topotecan and cyclophosphamide in a pediatric population.Materials and methodsPatients who were 1 to 30 years of age
Allen, Shelly, DuBois, Steven G, Gustafson, W Clay, Hollinger, Fabienne, Karski, Erin E, Long-Boyle, Janel R, Matthay, Katherine K, Nasholm, Nicole M, Shiboski, Stephen, Vo, Kieuhoa T   +9 more
core   +1 more source

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle, Kiersten Ricci, Kelly Blache, Rebecca A. Marsh, Adrienne M. Hammill, Elissa Engel   +5 more
wiley   +1 more source

Evaluation of antibiotic consumption using WHO -antimicrobial consumption tool and AWaRe classification

Journal of Family Medicine and Primary Care
Introduction: Antimicrobial resistance is a public health concern with global ramifications. Antibiotic misuse and overuse, are rampant in our country but more alarming is the data on the use of antibiotics primarily because of lack of access is another ...
Julie Birdie Wahlang, Reuben P. Syiem, Chayna Sarkar, Nari M. Lyngdoh, Iadarilang Tiewsoh, Dhriti K. Brahma, Aitilutmon Surong, Arky J Langstieh   +7 more
doaj   +1 more source

The effect and stability of MVCT images on adaptive TomoTherapy. [PDF]

, 2010
Use of helical TomoTherapy-based MVCT imaging for adaptive planning is becoming increasingly popular. Treatment planning and dose calculations based on MVCT require an image value to electron density calibration to remain stable over the course of ...
Paliwal, Bhudatt R, Rong, Yi, Tolakanahalli, Ranjini, Yadav, Poonam   +3 more
core   +1 more source

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Effect on Mortality of Higher Versus Lower β-Blocker (Metoprolol Succinate or Carvedilol) Dose in Patients With Heart Failure [PDF]

, 2018
This study aimed to compare the effect of β-blocker dose and heart rate (HR) on mortality in patients with heart failure with reduced ejection fraction (HFrEF).
Ajam, Samer, Ajam, Tarek, Devaraj, Srikant, Fudim, Marat, Kamalesh, Masoor   +4 more
core   +1 more source