Results 81 to 90 of about 6,869,765 (282)

DRUG UTILIZATION REVIEW OF FLUOROQUINOLONES ANTIBIOTICS BY USING PRESCRIBING INDICATORS & COMPARISON OF DEFINE DAILY DOSE & PRESCRIBED DAILY DOSE IN OUTPATIENTS

International Journal of Pharmacy & Integrated Health Sciences, 2021
Background: The increase in antibiotic resistance is new developing threat to healthcare system. Irrational drug use, polypharmacy and the current epidemic of bacterial resistance is attributed to the increase in use of antibiotics.
doaj   +1 more source

Qualitative and quantitative monitoring of antibiotics on dairy cattle farms in relation to animal welfare indicators

Italian Journal of Animal Science, 2023
Antimicrobial resistance is a growing concern for the scientific community and the public, so many countries have stepped up monitoring to tackle it and promote correct antimicrobial use. The welfare assessment protocol for dairy cows used by the Italian
Giuliano Borriello, Giulia Cagnotti, Elena Avedano, Stefania Bergagna, Piero Iannello, Giorgia Di Muro, Sara Ferrini, Antonio D’Angelo, Claudio Bellino   +8 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Antimicrobial consumption on Austrian dairy farms: an observational study of udder disease treatments based on veterinary medication records [PDF]

PeerJ, 2017
Background Antimicrobial use in livestock production is an important contemporary issue, which is of public interest worldwide. Antimicrobials are not freely available to Austrian farmers and can only be administered to livestock by veterinarians, or by ...
Clair L. Firth, Annemarie Käsbohrer, Corina Schleicher, Klemens Fuchs, Christa Egger-Danner, Martin Mayerhofer, Hermann Schobesberger, Josef Köfer, Walter Obritzhauser   +8 more
doaj   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Antipsychotic dose escalation as a trigger for Neuroleptic Malignant Syndrome (NMS): literature review and case series report [PDF]

, 2012
Background: “Neuroleptic malignant syndrome” (NMS) is a potentially fatal idiosyncratic reaction to any medication which affects the central dopaminergic system. Between 0.5% and 1% of patients exposed to antipsychotics develop the condition.
Daniel J Smith, Martin Daniel, Langan, J., Martin, D., Shahajan, P., Daniel Martin, Langan Julie, Smith Daniel J, Julie Langan, Polash Shajahan, Smith, D., Shajahan Polash   +11 more
core   +2 more sources

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Formulae for the calculation of the treatment incidence (TI) based on the animal defined daily dose (ADD; TI_ADD) and used daily dose (UDD; TI_UDD).

, 2016
Formulae for the calculation of the treatment incidence (TI) based on the animal defined daily dose (ADD; TIADD) and used daily dose (UDD; TIUDD).
Benedicte Callens (2179862), Jeroen Dewulf (2179868), Freddy Haesebrouck (149708), Geert Opsomer (2179872), Dominiek Maes (2179870), Aart de Kruif (2179874), Bart Pardon (2179864), Mia Vanrobaeys (2179866), Boudewijn Catry (416579)   +8 more
core   +1 more source

Logistic Stewardship: Supporting Antimicrobial Stewardship Programs Based on Antibiotics Goods Flow

Antibiotics
Background/Objectives: Antimicrobial resistance is a global threat to safe health care, and a reduction in antibiotic consumption seems to be an appropriate preventive measure.
Bianca Leistner, Dominic Rauschning, Ralf Matthias Hagen, Franziska Srečec, Nico Tom Mutters, Ruth Weppler, Christina Mutschnik, Manuel Döhla   +7 more
doaj   +1 more source