Results 81 to 90 of about 491,152 (275)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Antimicrobial consumption on Austrian dairy farms: an observational study of udder disease treatments based on veterinary medication records [PDF]

PeerJ, 2017
Background Antimicrobial use in livestock production is an important contemporary issue, which is of public interest worldwide. Antimicrobials are not freely available to Austrian farmers and can only be administered to livestock by veterinarians, or by ...
Clair L. Firth, Annemarie Käsbohrer, Corina Schleicher, Klemens Fuchs, Christa Egger-Danner, Martin Mayerhofer, Hermann Schobesberger, Josef Köfer, Walter Obritzhauser   +8 more
doaj   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Analisis Penggunaan Antibiotik pada Pasien Rawat Inap Dengan Metode Defined Daily Dose

, 2023
Antibiotik adalah obat yang digunakan untuk mencegah dan mengobati infeksi bakteri. Penggunaan antibiotik yang kurang tepat dapat memicu resistensi antibiotik yang merupakan masalah terbesar bagi kesehatan manusia.
Suharjono, Virdiyanti, Windi, Oktavia, Maria   +2 more
core   +1 more source

A Drug Utilization Evaluation of Bronchodilators Using a Defined Daily Dose Method

International Journal For Multidisciplinary Research, 2023
Drug therapy is crucial to promoting human health by increasing quality of life and extending lifespan. A method to assess and improve drug use is by conducting Drug Utilization Study. Drug utilization, in terms of DDD, aids in converting the available volume of medications into medically relevant units, allowing estimations of the number of people ...
Afreen Nasir -, Kaustav Ghosh -, Prabhu Das -   +2 more
openaire   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Average treatment incidences (min-max) based on the animal defined daily dose (ADD; TI_ADD) and the prescribed daily dose (UDD; TI_UDD) of the orally administered antimicrobial drugs in the veal herds (entire study period).

, 2016
Average treatment incidences (min-max) based on the animal defined daily dose (ADD; TIADD) and the prescribed daily dose (UDD; TIUDD) of the orally administered antimicrobial drugs in the veal herds (entire study period).
Benedicte Callens (2179862), Jeroen Dewulf (2179868), Freddy Haesebrouck (149708), Geert Opsomer (2179872), Dominiek Maes (2179870), Aart de Kruif (2179874), Bart Pardon (2179864), Mia Vanrobaeys (2179866), Boudewijn Catry (416579)   +8 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Retreatment of Patients Nonresponsive to Pegylated Interferon and Ribavirin with Daily High-Dose Consensus Interferon [PDF]

, 2010
Background. Current treatment of chronic hepatitis C with pegylated interferon and ribavirin has the ability to eliminate viral infection in about half of the patients treated.
Henry C. Bodenheimer, Douglas F. Meyer, David Bernstein, Hillel Tobias, Albert D. Min, Edward Brettholz, Ivanka Zic, David J. Clain, Franklin Klion, Arathi Rajendra   +9 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source