Results 181 to 190 of about 1,537,541 (269)

Treatment resistant depression in electronic health records: definitions matter. [PDF]

BMC Psychiatry
Iveson MH, Ball EL, Lo CWH, Falis M, Lewis CM, Whalley HC.   +5 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Defining peptides in ChEBI. [PDF]

J Cheminform
Flügel S, Mossakowski T, Neuhaus F, Pfanenstiel E, Glauer M, Haak E, Malik A, O'Boyle NM.   +7 more
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Editorial: Differentiating and defining “exposed” and “offshore” aquaculture and implications for aquaculture operation, management, costs, and policy

Frontiers in Aquaculture
Bela H. Buck, Bela H. Buck, Kevin Heasman, Tyler Sclodnick   +3 more
doaj   +1 more source

Beyond Psoriasis Area and Severity Index and Body Surface Area: An Italian Delphi Consensus on the Definition of Moderate Psoriasis. [PDF]

Dermatol Ther (Heidelb)
Gargiulo L, Costanzo A, Malagoli P, Burlando M, Marzano AV, Dapavo P, Girolomoni G, Pappagallo G, Loconsole F, Carugno A, Piaserico S, Megna M, Campanati A, Conti A, Balato A, Trovato E, Dini V, Carrera CG, Bardazzi F, Guarneri C, Orsini D, Bernardini N, Venturini M, Ribero S, Narcisi A.   +24 more
europepmc   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Case Definitions and Data Sources for NNCSS Parkinson Disease Surveillance: A Systematic Review.

JAMA Netw Open
Esper CD, Hogan KN, Abeysekara P, Smith KN, Smith TG, Mercer SL.   +5 more
europepmc   +1 more source

One Health in the public mind: Narrative constructions of zoonotic spillovers. [PDF]

One Health
Shanahan EA, Han X, Salam S, Washburn S, Slipher SK.   +4 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source