Results 191 to 200 of about 1,537,541 (269)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

What's a migraine day? Towards a consensus definition for clinical care and research - a Delphi panel-based study. [PDF]

J Headache Pain
De Loose L, Paemeleire K, Deligianni CI, Lampl C, Uluduz D, Tronvik E, Coppola G, Schytz H, Schoenen J, Del Rio MS, Martelletti P, Pozo-Rosich P, Gil-Gouveia R, Ryliskiene K, Sacco S, Ekizoglu E, Petrušić I, Fronczek R, Holland P, Reuter U, Goadsby PJ, MaassenVanDenBrink A, Versijpt J.   +22 more
europepmc   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Weight bias, stigma and discrimination: a call for greater conceptual clarity

Frontiers in Psychology
Marilou Côté, Marilou Côté, Vida Forouhar, Sabrina Sacco, Sabrina Sacco, Aurélie Baillot, Mary Himmelstein, Brad Hussey, Brad Hussey, Angela C. Incollingo Rodriguez, Taniya S. Nagpal, Sarah Nutter, Ian Patton, Rebecca L. Pearl, Rebecca M. Puhl, Ximena Ramos Salas, Ximena Ramos Salas, Shelly Russell-Mayhew, Angela S. Alberga   +18 more
doaj   +1 more source

Alternative Definitions of Floral Resource Availability Alter Inferred Plant Importance in Plant-Pollinator Networks. [PDF]

Ecol Evol
Yan H, Vaughan IP, Memmott J.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Quadratic Subproduct Systems, Free Products, and Their C*-Algebras. [PDF]

Integr Equ Oper Theory
Arici F, Ge Y.
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Developing a Fundamental Theoretical Definition for Athletic Injury: Metaphysics, Logic, and Mathematics. [PDF]

Sports Med
Kalkhoven JT.
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source