Results 201 to 210 of about 1,537,541 (269)

Prediction of Post-stenting Lumen Dimensions Using High-Definition Intravascular Ultrasound. [PDF]

JACC Adv
Wu W, Zhao S, Trivedi YV, Vijayarao SS, Patel P, Singh PV, Miriyala V, Alam MF, Chikatimalla R, Shaar A, Issa Y, Lee C, Brilakis ES, Dangas G, Chatzizisis YS.   +14 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Scoping literature review on applied definitions of very early diagnosis of systemic sclerosis (VEDOSS) and pre-systemic sclerosis in original articles. [PDF]

RMD Open
Lescoat A, Allanore Y, Del Galdo F, Kuwana M, Denton CP, Khanna D, Matucci-Cerinic M, Bellando-Randone S.   +7 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Developing a standard definition for sequences of concern. [PDF]

Front Bioeng Biotechnol
Alexanian T, Beal J, Bartling C, Berlips J, Carr PA, Clore A, Cozzarini H, Diggans J, El Moubayed Y, Esvelt K, Flyangolts K, Foner L, Fullerton PA, Gemler BT, Jagla CAD, Lababidi R, Mitchell T, Murphy ST, Parker MT, Roehner N, Rusch A, Talley K, Timmerman T, Wheeler NE.   +23 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Evaluation and enhancement of suspected opioid overdose definitions in emergency medical services data using machine learning with natural language processing. [PDF]

PLoS One
Rock P, Slavova S, Walsh SL, Martin J, Harris DR.   +4 more
europepmc   +1 more source

Long-Time Dynamics for the Kelvin-Helmholtz Equations Close to Circular Vortex Sheets. [PDF]

Arch Ration Mech Anal
Murgante F, Roulley E, Scrobogna S.
europepmc   +1 more source

Epidemiology and Comorbidity of Vitiligo in Germany: A Claims Data Analysis. [PDF]

Acta Derm Venereol
Klinger T, Augustin M, Baumeister S, Riedel J, Grellmann C, Kamps A, Böhm M, Hagenström K.   +7 more
europepmc   +1 more source