Results 191 to 200 of about 364,159 (261)

Acute Kidney Injury in Acute Heart Failure Revisited: Marker of Cardiorenal Disease Severity Rather Than Isolated Renal Injury. [PDF]

Life (Basel)
Aletras G, Bachlitzanaki M, Stratinaki M, Petrakis I, Pantazis Y, Foukarakis E, Hamilos M, Stylianou K.   +7 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The relevance of phenotypic definition in treatment resistant forms of major depressive disorder: a narrative review. [PDF]

Front Pharmacol
Paribello P, Isayeva U, Lazzardi S, Pinna M, Contu M, Meloni A, Pisanu C, Squassina A, Baune BT, Manchia M.   +9 more
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Clinical remission in allergy and clinical immunology practice: State of the art and World Allergy Organization (WAO) call to action. [PDF]

World Allergy Organ J
Morais-Almeida M, Canonica GW, Giavina-Bianchi P, Arasi S, Caminati M, Fiocchi A, Fonacier LS, Giavina-Bianchi M, Gómez RM, González-Diaz SN, Martin BL, Ortega Martell JA, Pitè H, Rouadi P, Sánchez Caraballo J, Villarreal-González RV, Virchow JC, Bachert C, Bernstein JA, Cianferoni A, Dávila I, Hanania NA, Heffler E, Nair P, Park HS, Saito H, Varricchi G, Yáñez A, Ansotegui IJ.   +28 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Definitions and outcomes reported in studies investigating the management of new onset atrial fibrillation in acutely unwell patients admitted to the intensive care unit: a scoping review. [PDF]

Eur Heart J Open
Johnston BW, Mathew J, Voller C, Hill RA, Blackwood B, Williams K, Hall A, Wilson K, Lobban TH, Lip GYH, Welters ID.   +10 more
europepmc   +1 more source

RECONSIDERING THE DEFINITION OF LIFE

Viva Origino, 2014
openaire   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source