Results 41 to 50 of about 75,316 (218)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Shock demagnetization in an ambient magnetic field at the Dhala impact structure, India

Communications Earth & Environment
Impact-generated shock waves can modify the remanent magnetization preserved in target rocks, yet their effects remain poorly constrained. Here we examine how shock waves modify rock magnetization by analysing unshocked granitoids and diorites, and shock-
Ambrish Kumar Pandey, Amar Agarwal, Gaurav Joshi, Satish Sangode, Mamilla Venkateshwarlu   +4 more
doaj   +1 more source

The correlation of austenite stability and sequence of strain accommodation during room temperature deformation of a duplex lightweight steel

Journal of Materials Research and Technology, 2021
The effect of austenite stability on the sequence of room temperature strain accommodation has been investigated in Fe-0.07C-11.15Mn-5.6Al-0.12Si lightweight steel through employing interrupted tensile tests coupled with electron backscattered ...
B. Mirshekari, A. Zarei-Hanzaki, A. Barabi, H.R. Abedi, S.-J. Lee, H. Fujii   +5 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Strategic niobium integration and thermomechanical processing in the advancement of novel CMnSiAlPMo TRIP-aided bainitic steel

Scientific Reports
This study examines the effects of niobium (Nb) addition and different thermomechanical controlled processing (TMCP) regimes on the flow stress behaviour and microstructure evolution of a newly developed CMnSiAlPMo TRIP-aided bainitic steel.
Hoda Refaiy, Eman El-Shenawy, Jukka Kömi, Mohammed Ali   +3 more
doaj   +1 more source

A Cold-Pressing Method Combining Axial and Shear Flow of Powder Compaction to Produce High-Density Iron Parts

Technologies, 2019
Highly performance methods for cold pressing (cold die forging) of preforms from iron powder with subsequent heat treatment and producing ready parts made of powder are described in the paper.
Sergey N. Grigoriev, Alexandr M. Dmitriev, Natalya V. Korobova, Sergey V. Fedorov   +3 more
doaj   +1 more source