Results 41 to 50 of about 354,715 (268)

Deformable Spectrograms [PDF]

, 2005
Speech and other natural sounds show high temporal correlation and smooth spectral evolution punctuated by a few, irregular and abrupt changes. In a conventional Hidden Markov Model (HMM), such structure is represented weakly and indirectly through transitions between explicit states representing 'steps' along such smooth changes.
Reyes-Gomez, Manuel, Jojic, Nebojsa, Ellis, Daniel P. W.   +2 more
openaire   +2 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Shock demagnetization in an ambient magnetic field at the Dhala impact structure, India

Communications Earth & Environment
Impact-generated shock waves can modify the remanent magnetization preserved in target rocks, yet their effects remain poorly constrained. Here we examine how shock waves modify rock magnetization by analysing unshocked granitoids and diorites, and shock-
Ambrish Kumar Pandey, Amar Agarwal, Gaurav Joshi, Satish Sangode, Mamilla Venkateshwarlu   +4 more
doaj   +1 more source

The correlation of austenite stability and sequence of strain accommodation during room temperature deformation of a duplex lightweight steel

Journal of Materials Research and Technology, 2021
The effect of austenite stability on the sequence of room temperature strain accommodation has been investigated in Fe-0.07C-11.15Mn-5.6Al-0.12Si lightweight steel through employing interrupted tensile tests coupled with electron backscattered ...
B. Mirshekari, A. Zarei-Hanzaki, A. Barabi, H.R. Abedi, S.-J. Lee, H. Fujii   +5 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Strategic niobium integration and thermomechanical processing in the advancement of novel CMnSiAlPMo TRIP-aided bainitic steel

Scientific Reports
This study examines the effects of niobium (Nb) addition and different thermomechanical controlled processing (TMCP) regimes on the flow stress behaviour and microstructure evolution of a newly developed CMnSiAlPMo TRIP-aided bainitic steel.
Hoda Refaiy, Eman El-Shenawy, Jukka Kömi, Mohammed Ali   +3 more
doaj   +1 more source