Results 51 to 60 of about 75,316 (218)

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Improving the Cleanness of Low-Carbon Tube Steel Under Steel Plant Conditions

Advances in Materials Science and Engineering
Reducing the number of nonmetallic inclusions in high-quality steel rolled products is of great importance for all steel plants. One of the ways to decrease the size and quantity of alumina and silicate nonmetallic inclusions could be suppressing their ...
Dmytro Zotov, Kostiantyn Niziaiev, Oleg Uzlov, Oleksandr Puchykov   +3 more
doaj   +1 more source

DEFORMED INSTANTONS [PDF]

CPT and Lorentz Symmetry, 2005
In this talk, instantons are discussed in the presence of Lorentz violation. Conventional topological arguments are applied to classify the modified solutions to the Yang-Mills equations according to the topological charge. Explicit perturbations to the instantons are calculated in detail for the case of unit topological charge.
Colladay, Don, McDonald, Patrick
openaire   +2 more sources

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Unlocking property constraints through a multi-level ordered structure strategy

Nature Communications
Materials with unprecedented and exotic properties are crucial for addressing energy and environmental crisis. However, many existing materials are approaching performance limits due to inherent physical constraints. Here, we report a multi-level ordered
Li Lou, Jiaxu Li, Xiang Luo, Tao Zhang, Xinzhou Li, Qianyong Zhu, Yun Du, Zhiwen Bi, Xiaohua Sun, Qiwei Cheng, Yuting Xiao, Shiteng Zhao, Bin Wen, Xiangyi Zhang, Hai-Tian Zhang   +14 more
doaj   +1 more source

Fragmentation /spheroidization of constituent phases and correlated flow softening during thermomechanical processing of AlCoCrFeNi2.1 eutectic high entropy alloy

Journal of Materials Research and Technology
The present study explores the morphological evolutions of constituent phases during the hot deformation process of a promising as-cast AlCoCrFeNi2.1 eutectic high-entropy alloy. Through which, a quasi-in-situ approach was employed using the Poliak-Jonas
K. Bahrami, A. Zarei-Hanzaki, M. Mahmoudi, J. Charkhchian, M.M. Jafarzad-Shayan, A. Moshiri, S. Sadeghpour, H.R. Abedi   +7 more
doaj   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source