Results 71 to 80 of about 970,078 (305)

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Cryptanalysis and improvement of a distributed zero trust scheme for airborne wireless sensor networks

Scientific Reports
The advancement of airborne wireless sensor networks (AWSNs) in modern aircraft monitoring has introduced heightened risks to security isolation, particularly from insider threats. Namely, the bidirectional real-time data flows enable attackers to hijack
Feihong Xu, Fei Zhu, Junhua Wang, Saru Kumari, Kadambri Agarwal, Yuelei Zhang, Qing An   +6 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Improving the Cleanness of Low-Carbon Tube Steel Under Steel Plant Conditions

Advances in Materials Science and Engineering
Reducing the number of nonmetallic inclusions in high-quality steel rolled products is of great importance for all steel plants. One of the ways to decrease the size and quantity of alumina and silicate nonmetallic inclusions could be suppressing their ...
Dmytro Zotov, Kostiantyn Niziaiev, Oleg Uzlov, Oleksandr Puchykov   +3 more
doaj   +1 more source

Quadratic differentials and equivariant deformation theory of curves [PDF]

, 2012
Given a finite p-group G acting on a smooth projective curve X over an algebraically closed field k of characteristic p, the dimension of the tangent space of the associated equivariant deformation functor is equal to the dimension of the space of ...
Koeck, Bernhard, Kontogeorgis, Aristides
core   +2 more sources

A new inverse trigonometric shear deformation theory for isotropic and functionally graded sandwich plates [PDF]

, 2014
A new inverse trigonometric shear deformation theory is proposed for the static, buckling and free vibration analyses of isotropic and functionally graded (FG) sandwich plates.
Thai, Huu-Tai, Vo, Thuc, Nguyen, Van-Hau, Nguyen, Trung-Kien   +3 more
core   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Strategic niobium integration and thermomechanical processing in the advancement of novel CMnSiAlPMo TRIP-aided bainitic steel

Scientific Reports
This study examines the effects of niobium (Nb) addition and different thermomechanical controlled processing (TMCP) regimes on the flow stress behaviour and microstructure evolution of a newly developed CMnSiAlPMo TRIP-aided bainitic steel.
Hoda Refaiy, Eman El-Shenawy, Jukka Kömi, Mohammed Ali   +3 more
doaj   +1 more source

Fragmentation /spheroidization of constituent phases and correlated flow softening during thermomechanical processing of AlCoCrFeNi2.1 eutectic high entropy alloy

Journal of Materials Research and Technology
The present study explores the morphological evolutions of constituent phases during the hot deformation process of a promising as-cast AlCoCrFeNi2.1 eutectic high-entropy alloy. Through which, a quasi-in-situ approach was employed using the Poliak-Jonas
K. Bahrami, A. Zarei-Hanzaki, M. Mahmoudi, J. Charkhchian, M.M. Jafarzad-Shayan, A. Moshiri, S. Sadeghpour, H.R. Abedi   +7 more
doaj   +1 more source