Results 61 to 70 of about 970,078 (305)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The high temperature deformation behavior of a triplex (ferrite+ austenite+ martensite) low density steel

Journal of Materials Research and Technology, 2021
The present work deals with the high temperature deformation behavior of Fe-11.15Mn-5.6Al-0.07C (wt.%) triplex ferrite-based lightweight steel in the temperature range of 800–1100 °C under the strain rate of 0.001 to 0.1s−1.
Amir-Reza Kalantari, Abbas Zarei-Hanzaki, Hamid Reza Abedi, Mohammad Sadegh Jalali, Seong-Jun Park, Jun Young Park   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Nanostructures in Ti processed by severe plastic deformation [PDF]

, 2003
Metals and alloys processed by severe plastic deformation (SPD) can demonstrate superior mechanical properties, which are rendered by their unique defect structures.
Ma, E., Wang, Y. M., Valiev, R. Z., Huang, J. Y., Gubicza, Jenő, Zhu, Y. T., Ungár, Tamás   +6 more
core   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Shock demagnetization in an ambient magnetic field at the Dhala impact structure, India

Communications Earth & Environment
Impact-generated shock waves can modify the remanent magnetization preserved in target rocks, yet their effects remain poorly constrained. Here we examine how shock waves modify rock magnetization by analysing unshocked granitoids and diorites, and shock-
Ambrish Kumar Pandey, Amar Agarwal, Gaurav Joshi, Satish Sangode, Mamilla Venkateshwarlu   +4 more
doaj   +1 more source

Permeability evolution during progressive development of deformation bands in porous sandstones [PDF]

, 2003
Triaxial deformation experiments were carried out on large (0.1 m) diameter cores of a porous sandstone in order to investigate the evolution of bulk sample permeability as a function of axial strain and effective confining pressure. The log permeability
Kwon, O., I. G. Main, B. T. Ngwenya, S. C. Elphick, Ngwenya, B. T., Elphick, S. C., Main, I. G.; id_orcid, O. Kwon   +7 more
core   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

The correlation of austenite stability and sequence of strain accommodation during room temperature deformation of a duplex lightweight steel

Journal of Materials Research and Technology, 2021
The effect of austenite stability on the sequence of room temperature strain accommodation has been investigated in Fe-0.07C-11.15Mn-5.6Al-0.12Si lightweight steel through employing interrupted tensile tests coupled with electron backscattered ...
B. Mirshekari, A. Zarei-Hanzaki, A. Barabi, H.R. Abedi, S.-J. Lee, H. Fujii   +5 more
doaj   +1 more source