Results 41 to 50 of about 165,935,065 (199)
Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
FEBS Letters, EarlyView.The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Special Lagrangian submanifolds with isolated conical singularities. II. Moduli spaces [PDF]
, 2002 This is the second in a series of five papers math.DG/0211294, math.DG/0302355, math.DG/0302356, math.DG/0303272 studying special Lagrangian submanifolds (SL m-folds) X in (almost) Calabi-Yau m-folds M with singularities x_1,...,x_n locally modelled on ...
Joyce, D, Joyce, Dominic
core +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Deformations of Inhomogeneous Simple Singularities and Quiver Representations
, 2021 International audienceThis article is a summary of the author's unpublished Ph.D thesis (Caradot 2017). Its purpose is to generalise a construction by H. Cassens and P. Slodowy of the semiuniversal deformations of the simple singularities of type A(r), D-
Caradot, Antoine, Antoine Caradot
core +1 more source
The discriminant of quasi m-boundary singularities
Demonstratio MathematicaWe describe the discriminant of deformations of simple quasi m-boundary equivalence classes for m≥2m\ge 2. All quasi simple mm-boundary classes are right equivalent to Arnold’s singularities (ADE).
Alharbi Fawaz, Al-hudhali Eman
doaj +1 more source
Journal of High Energy Physics, 2017 We study the class of indecomposable two-dimensional Landau-Ginzburg theories with (2,2) supersymmetry and central charge c < 6 with the aim of classifying all such theories up to marginal deformations.
Ian C. Davenport, Ilarion V. Melnikov
doaj +1 more source
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
Polarization singularities in isotropic random vector waves [PDF]
, 2001 Following Nye & Hajnal, we explore the geometry of complex vector waves by regarding them as a field of polarization ellipses. Singularities of this field are the C lines and L lines, where the polarization is purely circular and purely linear ...
Dennis, MR +5 more
core +1 more source