Results 111 to 120 of about 145,745 (278)

The Future Evolution of White Dwarf Stars Through Baryon Decay and Time Varying Gravitational Constant

, 2008
Motivated by the possibility that the fundamental ``constants'' of nature could vary with time, this paper considers the long term evolution of white dwarf stars under the combined action of proton decay and variations in the gravitational constant ...
D.A. Dicus, D.N. Spergel, F.C. Adams, F.C. Adams, F.J. Dyson, Fred C. Adams, J.D. Barrow, J.D. Barrow, J.M. Islam, J.P. Uzan, Jacob A. Ketchum, K. Nagamine, M.M. Cirkovic, P.C.W. Davies, S. Chandrasekhar, S.L. Shapiro, S.T. Thornton, S.W. Hawking, Super-Kamiokande Collaboration, Y.B. Zel’dovich   +19 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Perturbation Analysis of the Kuramoto Phase Diffusion Equation Subject to Quenched Frequency Disorder

, 2009
The Kuramoto phase diffusion equation is a nonlinear partial differential equation which describes the spatio-temporal evolution of a phase variable in an oscillatory reaction diffusion system.
A. Pikovsky, A. S. Mikhailov, A. T. Winfree, B. Blasius, B. Blasius, Bernd Blasius, J. R. Baumgardner, Ralf Tönjes, Y. Kuramoto   +8 more
core   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Quantum characteristics of a nondegenerate three-level laser with NDPA pumped by electron bombardment

Physics Open
This study investigates the entanglement and squeezing characteristics of light generated by a non-degenerate, three-level laser with a non-degenerate parametric amplifier, which is pumped by electron bombardment to the top level and coupled to a two ...
Aliyyi Adem
doaj   +1 more source

Study on Hysteresis Model of Welding Material in Unstiffened Welded Joints of Steel Tubular Truss Structure

Applied Sciences, 2018
The weld form of intersecting joints in a steel tubular truss structure changes with the various intersecting curves. As the key role of joints in energy dissipation and seismic resistance, the weld is easy to damage, as a result the constitutive ...
Yaqi Suo, Wenwei Yang, Peng Chen
doaj   +1 more source

Neutrino processes in partially degenerate neutron matter

, 2012
We investigate neutrino processes for conditions reached in simulations of core-collapse supernovae. Where neutrino-matter interactions play an important role, matter is partially degenerate, and we extend earlier work that addressed the degenerate ...
Bacca, S., Hally, K., Liebendörfer, M., Perego, A., Pethick, C. J., Schwenk, A.   +5 more
core   +1 more source

Analytic semigroups and some degenerate evolution equations defined on domains with corners

Discrete & Continuous Dynamical Systems - A, 2015
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
ALBANESE, Angela Anna, MANGINO, Elisabetta Maria   +1 more
openaire   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source