Results 91 to 100 of about 696,209 (319)

Paramagnetic Rim Lesions Are Associated With Trans‐Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem, Angel Liu, Sargis Manukyan, Mustafa Subhi, Elaina Luskin, Bryan Quah, Sreekanth Madhusoodhanan Nair, Arzu C. Has Silemek, Gabriela Zabala, Yujie Cui, Laura Locke, Paula Barreras, Marwa Kaisey, Vinicius Calsavara, Daniel S. Reich, Nancy L. Sicotte, Pascal Sati, Omar Al‐Louzi   +17 more
wiley   +1 more source

Transcriptomic analyses and machine-learning methods reveal dysregulated key genes and potential pathogenesis in human osteoarthritic cartilage

Bone & Joint Research
Aims: This study aimed to explore the biological and clinical importance of dysregulated key genes in osteoarthritis (OA) patients at the cartilage level to find potential biomarkers and targets for diagnosing and treating OA. Methods: Six sets of gene
Di Zhao, Ling-feng Zeng, Gui-hong Liang, Ming-hui Luo, Jian-ke Pan, Yao-xing Dou, Fang-zheng Lin, He-tao Huang, Wei-yi Yang, Jun Liu   +9 more
doaj   +1 more source

Dissociating memory networks in early Alzheimer's disease and frontotemporal lobar degeneration - a combined study of hypometabolism and atrophy

, 2013
Introduction: We aimed at dissociating the neural correlates of memory disorders in Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD).
Barbara Vogt, Müller, Karsten, Becker, G., Dukart, J., Frisch, Stefan, Osama Sabri, Dukart, Jürgen, Horstmann, A., Schroeter, Matthias, Vogt, B., Sabri, O., Mueller, K. ; https://orcid.org/, Matthias L Schroeter, Barthel, H., Sabri, Osama, Juergen Dukart, Villringer, Arno, Karsten Müller, Villringer, A. ; https://orcid.org/, Henryk Barthel, Vogt, Barbara, Stefan Frisch, Becker, Georg, Frisch, S. ; https://orcid.org/, Annette Horstmann, Arno Villringer, Barthel, Henryk, Schroeter, M. ; https://orcid.org/, Horstmann, Annette, Georg Becker   +29 more
core   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Knee muscle strength as a mediator of sex differences in incident knee osteoarthritis

Arthritis Research & Therapy
Background Females have a higher risk of incident knee osteoarthritis (KOA) than males, particularly in the lateral compartment; however, the underlying mechanisms remain unclear.
Xiaoxiao Li, Ziying Wu, Yuqing Zhang, Chao Zeng, Guanghua Lei, Jie Wei, Jiatian Li, Yongbing Xiao   +7 more
doaj   +1 more source

Polyethylene microplastics transported to nucleus pulposus cells via macrophages-derived exosomes, and promote intervertebral disc degeneration through NAT10/SLC7A11 and ac4C modification

Ecotoxicology and Environmental Safety
Background: Intervertebral disc degeneration (IVDD) serves as the fundamental pathological basis for low back pain. Microplastics influence the organisms through exosomes-mediated communication.
Weilin Zhang, Kuize Liu, Zhencong Li, Dao Feng, Boyuan Zhou, Wei Zhao, Shengbang Huang, Zhiwen Dai, Jinguo Liang, Siyuan Chen, Yen Wei, Jinsong Wei   +11 more
doaj   +1 more source

MACULAR DEGENERATION [PDF]

The Journal OF Nervous and Mental Disease, 1920
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openaire   +1 more source

Progressive retinal degeneration and glial activation in the Cln6nclf mouse model of neuronal ceroid lipofuscinosis : a beneficial effect of DHA and Curcumin supplementation

, 2013
Neuronal ceroid lipofuscinosis (NCL) is a group of neurodegenerative lysosomal storage disorders characterized by vision loss, mental and motor deficits, and spontaneous seizures.
Monica Langiu, Myriam Mirza, Langiu, Monica, Tamm, Ernst R., Mirza, Myriam, Langmann, Thomas, Ernst R. Tamm, Aleksandra Somogyi, Marcus Karlstetter, Mika O. Ruonala, Volz, Cornelia, Jägle, Herbert, Herbert Jägle, Ernst R Tamm, Somogyi, Aleksandra, Cornelia Volz, Thomas Langmann, Mika O Ruonala, Karlstetter, Marcus, Ruonala, Mika O.   +19 more
core   +1 more source

Clinical Validation of Plasma p‐217tau in Neurological Diseases

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi, Takumi Nakamura, Ryoma Takahashi, Tetsuya Ueda, Seiji Kinoshita, Chikage Uchida, Takashi Sugawara, Kentaro Hashimoto, Kunihiko Ishizawa, Masakuni Amari, Hiroo Kasahara, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoji   +13 more
wiley   +1 more source

Racial/ethnic differences in neuropsychological test performance in frontotemporal degeneration

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
BACKGROUND Racial and/or ethnic differences in neuropsychological test performance are understudied in frontotemporal degeneration (FTD) but their identification is critical to identifying ways to improve care of representative FTD populations.
Melanie A. Matyi, Emma Rhodes, Sheina Emrani, Hannah A. Jin, David J. Irwin, Corey T. McMillan, Lauren Massimo   +6 more
doaj   +1 more source