Results 91 to 100 of about 4,732,020 (409)

The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise

FEBS Open Bio, EarlyView.
Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji, Hae Sung Lee, Haesung Lee, Jong‐Hee Kim   +3 more
wiley   +1 more source

Mechanically stimulated osteocytes maintain tumor dormancy in bone metastasis of non-small cell lung cancer by releasing small extracellular vesicles

eLife
Although preclinical and clinical studies have shown that exercise can inhibit bone metastasis progression, the mechanism remains poorly understood. Here, we found that non-small cell lung cancer (NSCLC) cells adjacent to bone tissue had a much lower ...
Jing Xie, Yafei Xu, Xuhua Liu, Li Long, Ji Chen, Chunyan Huang, Yan Shao, Zhiqing Cai, Zhimin Zhang, Ruixin Zhou, Jiarong Leng, Xiaochun Bai, Qiancheng Song   +12 more
doaj   +1 more source

Progressive Myoclonus Epilepsy: Distinctive MRI Changes in Cerebellar and Motor Networks

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progressive myoclonus epilepsy (PME) is a rare generalized epilepsy syndrome with a well‐characterized genetic basis. The brain networks that are affected to give rise to the distinctive symptoms of PME are less well understood. Methods Eleven individuals with PME with a confirmed genetic diagnosis and 22 controls were studied.
Jillian M. Cameron, Remika Mito, Samuel F. Berkovic, Graeme D. Jackson   +3 more
wiley   +1 more source

Diversified Multi-prototype Representation for Semi-supervised Segmentation [PDF]

arXiv, 2021
This work considers semi-supervised segmentation as a dense prediction problem based on prototype vector correlation and proposes a simple way to represent each segmentation class with multiple prototypes. To avoid degenerate solutions, two regularization strategies are applied on unlabeled images.
arxiv  

Artificial intelligence-based decision-making for age-related macular degeneration

Theranostics, 2019
Artificial intelligence (AI) based on convolutional neural networks (CNNs) has a great potential to enhance medical workflow and improve health care quality.
De-Kuang Hwang, Chih-Chien Hsu, Kao-Jung Chang, Daniel L. Chao, Chuanhao Sun, Ying-Chun Jheng, A. Yarmishyn, Jau-Ching Wu, Ching-Yao Tsai, Mong-Lien Wang, Chi-Hsien Peng, Ke-Hung Chien, C. Kao, Tai-Chi Lin, L. Woung, Shih-Jen Chen, S. Chiou   +16 more
semanticscholar   +1 more source

‘This growing genetic disaster’: obesogenic mothers, the obesity ‘epidemic’ and the persistence of eugenics [PDF]

, 2013
In this era of ever-increasing emphasis on personal responsibility the 'obesity epidemic', officialised in global health warnings, threatens to swamp the West with the consequences of overindulgence.
Cain, Ruth
core   +2 more sources

Early Language Impairment as an Integral Part of the Cognitive Phenotype in Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Huntington's disease (HD) speech/language disorders have typically been attributed to motor and executive impairment due to striatal dysfunction. In‐depth study of linguistic skills and the role of extrastriatal structures in HD is scarce.
Arnau Puig‐Davi, Carla Franch‐Marti, Iñigo Ruiz‐Barrio, Frederic Sampedro, Jesus Perez‐Perez, Jordi A. Matias‐Guiu, Fernando Cuetos, Gonzalo Olmedo‐Saura, Laura Perez‐Carasol, Andrea Horta‐Barba, Ignacio Aracil‐Bolaños, Javier Pagonabarraga, Jaime Kulisevsky, Saul Martinez‐Horta   +13 more
wiley   +1 more source

CircECE1 activates energy metabolism in osteosarcoma by stabilizing c-Myc

Molecular Cancer, 2020
Background Osteosarcoma (OS) is the most common malignant bone tumor and has a poor prognosis. The potential involvement of circular RNAs (circRNAs) in OS progression remains unexplored.
Shuying Shen, Teng Yao, Yining Xu, Deguang Zhang, Shunwu Fan, Jianjun Ma   +5 more
doaj   +1 more source

Morphometric analyses of the visual pathways in macular degeneration

, 2014
Introduction. Macular degeneration (MD) causes central visual field loss. When field defects occur in both eyes and overlap, parts of the visual pathways are no longer stimulated.
Baseler, Heidi A., Cornelissen, Frans W., Gouws, Andre, Greenlee, Mark W., Hernowo, Aditya T., Hooymans, Johanna M. M., Morland, Antony B., Plank, Tina, Prins, Doety   +8 more
core   +2 more sources

Kufor-Rakeb syndrome, pallido-pyramidal degeneration with supranuclear upgaze paresis and dementia, maps to 1p36 [PDF]

, 2001
Kufor-Rakeb syndrome is an autosomal recessive nigro-striatal-pallidal-pyramidal neurodegeneration. The onset is in the teenage years with clinical features of Parkinson’s disease plus spasticity, supranuclear upgaze paresis, and dementia.
Al-Din, A., Bond, J., Crow, Y., Hampshire, D.J., Mubaidin, A., Roberts, E., Woods, C.G., Wriekat, A.L.   +7 more
core   +2 more sources