Results 81 to 90 of about 564,044 (302)

\u27Whatsoever a Man Soweth:\u27 Sex Education about Venereal Disease, Racial Health, and Social Hygiene during the First World War [PDF]

, 2018
In 1917, the British War Office released a film directed by Joseph Best titled Whatsoever a Man Soweth. The 38-minute silent film used intertitles to convey dialogue, and the film’s narrative, which focuses on three Canadian soldiers on leave in London ...
Brenyo, Brent
core   +1 more source

Some clinical aspects of rheumatoid arthritis [PDF]

, 1959
In our department we have been placing a special emphasis on the treatment and study of rheumatoid arthritis, and during the last four years we have handled about 1,600 cases visiting our outpatient clinic and approximately 100 hospitalized cases.
Kodama, Toshio
core   +1 more source

Clinical Spectrum and Outcomes of SOX1 Antibody‐Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye, Zu‐Ying Kuang, Bo Li, Meng‐Qiu Pan, Li‐Hua Zhou, Yang‐Yang Dai, Si‐Fen Xie, Xian‐Guang Lin, Ye‐Peng Hu, Li‐Hong Jiang, Zhan‐Hang Wang, Wei‐Jing Zhang   +11 more
wiley   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Bindarit Reduces Bone Loss in Ovariectomized Mice by Inhibiting CCL2 and CCL7 Expression via the NF‐κB Signaling Pathway

Orthopaedic Surgery, 2022
Objective To investigate the changes in proinflammatory cytokines and chemokines, namely, C‐C motif ligand (CCL) 2 and CCL7, in postmenopausal osteoporosis (PMOP) and to develop a new drug, bindarit (Bnd), for PMOP in an ovariectomized (OVX) mouse model.
Shi‐guo Yuan, Hong‐ling Hu, Xin‐jia Wang, Jin‐cheng Yang, Rong‐ping Zhou, Xiao‐chun Bai, Ping‐lin Lai   +6 more
doaj   +1 more source

Republican Monsters: The Cultural Construction of American Positivist Criminology, 1767-1920 [PDF]

, 2019
This dissertation examines the history of and cultural influences on positivist criminology in the United States. From Benjamin Rush to the present day, the U.S.
Burton, Chase Smith
core  

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

Differential diagnosis of adrenal masses by chemical shift and dynamic gadolinium enhanced MR imaging. [PDF]

, 2003
Chemical shift MRI is widely used for identifying adenomas, but it is not a perfect method. We determined whether combined dynamic MRI methods can lead to improved diagnostic accuracy.
Akaki, Shiro, Hiraki, Yoshio, Sasai, Nobuya, Sei, Tetsuro, Togami, Izumi, Tsunoda, Masatoshi   +5 more
core   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

The current state and issues of medical treatment for age-related macular degeneration

Folia Pharmacologica Japonica, 2008
滲出型加齢黄斑変性の中心的病態は，脈絡膜血管新生であり，新生血管の透過性亢進による滲出性変化が神経網膜を恒久的に傷害する．近年の細胞生物学の進歩は，これらの病態における複数の分子メカニズムを明らかにしてきたため，特定の分子を標的とした阻害薬が開発される時代になった．なかでも血管内皮増殖因子（VEGF）は，進行の鍵となる2つの病態，血管新生・血管透過性亢進を促進することが明らかにされ，その阻害薬の臨床応用が実現した．眼科領域で臨床応用されたVEGF阻害薬pegaptanib（Macugen®），ranibizumab（Lucentis®），bevacizumab（Avastin®）は，黄斑浮腫・剥離や血管新生を軽減させ，少なくとも短期的には有効であることがわかった．しかし，至適な投与法，長期の安全性 ...
openaire   +3 more sources