Results 101 to 110 of about 4,732,020 (409)

A Novel CHMP2B Splicing Variant in Atypical Presentation of Familial Frontotemporal Lobar Degeneration

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT C‐truncating variants in the charged multivesicular body protein 2B (CHMP2B) gene are a rare cause of frontotemporal lobar degeneration (FTLD), previously identified only in Denmark, Belgium, and China. We report a novel CHMP2B splice‐site variant (c.35‐1G>A) associated with familial FTLD in Spain. The cases were two monozygotic male twins who
Sara Rubio‐Guerra, Sara Bernal, David Almenta, Josefina Pérez‐Blanco, Valle Camacho, Isabel Sala, Mª Belén Sánchez‐Saudinós, Jesús García Castro, Judit Selma‐González, Miguel Ángel Santos‐Santos, Álvaro Carbayo, Janina Turon‐Sans, Ricard Rojas‐Garcia, Daniel Alcolea, Juan Fortea, Alberto Lleó, Oriol Dols‐Icardo, Ignacio Illán‐Gala   +17 more
wiley   +1 more source

Dose-Dependent Effects of Lipopolysaccharide on the Endothelium—Sepsis versus Metabolic Endotoxemia-Induced Cellular Senescence

Antioxidants
The endothelium, the innermost cell layer of blood vessels, is not only a physical barrier between the bloodstream and the surrounding tissues but has also essential functions in vascular homeostasis.
Dennis Merk, Fiona Frederike Cox, Philipp Jakobs, Simone Prömel, Joachim Altschmied, Judith Haendeler   +5 more
doaj   +1 more source

The spatial form periosteal-bone complex promotes bone regeneration by coordinating macrophage polarization and osteogenic-angiogenic events

Materials Today Bio, 2021
Bone defects associated with soft tissue injuries are an important cause of deformity that threatens people’s health and quality of life. Although bone substitutes have been extensively explored, effective biomaterials that can coordinate early ...
C. Zhao, P. Qiu, M. Li, K. Liang, Z. Tang, P. Chen, J. Zhang, S. Fan, X. Lin   +8 more
doaj  

Fructose-bisphosphatase1 (FBP1) alleviates experimental osteoarthritis by regulating Protein crumbs homolog 3 (CRB3)

Arthritis Research & Therapy, 2023
Purpose To identify the role of gluconeogenesis in chondrocytes in osteoarthritis (OA). Materials and methods Cartilage samples were collected from OA patients and C57 mice and were stained with Safranin O-Fast Green to determine the severity of OA ...
Zhuolun Wang, Xinjie Wang, Liangliang Liu, Xiongtian Guo, Haiyan Zhang, Jianbing Yin, Rengui Lin, Yan Shao, Daozhang Cai   +8 more
doaj   +1 more source

AlignShift: Bridging the Gap of Imaging Thickness in 3D Anisotropic Volumes [PDF]

, 2020
This paper addresses a fundamental challenge in 3D medical image processing: how to deal with imaging thickness. For anisotropic medical volumes, there is a significant performance gap between thin-slice (mostly 1mm) and thick-slice (mostly 5mm) volumes.
arxiv   +1 more source

Medical Compliance of Fibrate and the Decreased Risk of Age-Related Macular Degeneration in Dyslipidemia-Related Diseases: A Population-Based Cohort Study [PDF]

, 2021
Kai Wang, Ming‐Ju Hsieh, Hsiang‐Wen Chien, Chia‐Yi Lee, Chao‐Bin Yeh, Jing‐Yang Huang, Shun‐Fa Yang   +6 more
openalex   +1 more source

Widening use of dexamethasone implant for the treatment of macular edema [PDF]

, 2017
Sustained-release intravitreal 0.7 mg dexamethasone (DEX) implant is approved in Europe for the treatment of macular edema related to diabetic retinopathy, branch retinal vein occlusion, central retinal vein occlusion, and non-infectious uveitis.
Avitabile T., Bonfiglio V., Fallico M., Fichera S., Longo A., Macchi I., Pizzo A., Rapisarda C., Reibaldi M., Russo A.   +9 more
core   +2 more sources

Cerebello‐Prefrontal Connectivity Underlying Cognitive Dysfunction in Spinocerebellar Ataxia Type 2

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 2 (SCA2) is a hereditary cerebellar degenerative disorder, with motor and cognitive symptoms. The constellation of cognitive symptoms due to cerebellar degeneration is named cerebellar cognitive affective syndrome (CCAS), which has increasingly been recognized to profoundly impact patients' quality of life;
Ami Kumar, Ruo‐Yah Lai, Zena Fadel, Yicheng Lin, Pia Parekh, Rachel Griep, Ming‐Kai Pan, Sheng‐Han Kuo   +7 more
wiley   +1 more source

Preparation and Characterization of an Optimized Meniscal Extracellular Matrix Scaffold for Meniscus Transplantation

Frontiers in Bioengineering and Biotechnology, 2020
Many studies have sought to construct a substitute to partially replace irreparably damaged meniscus. Only the meniscus allograft has been used in clinical practice as a useful substitute, and there are concerns about its longevity and inherent ...
Yong He, Yong He, Yunbin Chen, Yunbin Chen, Yunbin Chen, Xinyu Wan, Xinyu Wan, Xinyu Wan, Chenchen Zhao, Chenchen Zhao, Pengcheng Qiu, Pengcheng Qiu, Xianfeng Lin, Xianfeng Lin, Jianfeng Zhang, Jianfeng Zhang, Yue Huang, Yue Huang   +17 more
doaj   +1 more source

TGFβ reprograms TNF stimulation of macrophages towards a non-canonical pathway driving inflammatory osteoclastogenesis

Nature Communications, 2022
Mechanisms for inflammatory osteolysis are unclear. Here, Xia et al. find that TGFβ shifts the inflammatory action of TNF on macrophages to a potent osteoclastogenic function and identify a novel TGFβ/TNF-mediated non-canonical osteoclastogenic program.
Yuhan Xia, Kazuki Inoue, Yong Du, Stacey J. Baker, E. Premkumar Reddy, Matthew B. Greenblatt, Baohong Zhao   +6 more
doaj   +1 more source