Results 241 to 250 of about 38,202 (297)

Microplastics matter: practical implications of the EU REACH restriction for the pharmaceutical industry. [PDF]

Front Drug Deliv
Janssen PHM, Rijpkema WA, Bisharat L, Orbons M, Jaspers M, Dickhoff BHJ.   +5 more
europepmc   +1 more source

Black soldier fly protein-based microencapsulation of lemongrass oil improves rumen fermentation efficiency and mitigates methane production <i>in vitro</i>. [PDF]

Vet World
Matra M, Suriyapha C, Dagaew G, Prachumchai R, Phupaboon S, Sommai S, Haitook T, Kunhareang S, Wanapat M.   +8 more
europepmc   +1 more source

Stress relaxation timescale and hydrogel network connectivity regulate neural progenitor cell stemness and differentiation.

J Mater Chem B
Brown LE, Bakker D, Zhou P, Madl CM.
europepmc   +1 more source

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To Degrade or Not to Degrade DNMT3A

Cancer Discovery, 2022
Abstract Summary: Aberrant DNA cytosine methylation is a critical contributor to compromised tissue regeneration and malignant transformation, particularly during aging. In this issue of Cancer Discovery, Huang and colleagues define a new class of disease-associated DNA (cytosine-5-)-methyltransferase
Yuhong, Ma, Britta, Will
openaire   +2 more sources

Protein folding and degradation in bacteria:¶To degrade or not to degrade? That is the question

Cellular and Molecular Life Sciences, 2002
In Escherichia coli protein quality control is carried out by a protein network, comprising chaperones and proteases. Central to this network are two protein families, the AAA+ and the Hsp70 family. The major Hsp70 chaperone. DnaK, efficiently prevents protein aggregation and supports the refolding of damaged proteins. In a special case, DnaK, together
Dougan, David A., Mogk, Axel, Bukau, Bernd   +2 more
openaire   +3 more sources

STARCH DEGRADATION

Annual Review of Plant Biology, 2005
Recent research reveals that starch degradation in Arabidopsis leaves at night is significantly different from the “textbook” version of this process. Although parts of the pathway are now understood, other parts remain to be discovered. Glucans derived from starch granules are hydrolyzed via β-amylase to maltose, which is exported from the ...
Smith, Alison M., Zeeman, Samuel C., Smith, Steven M.   +2 more
openaire   +3 more sources

To Degrade or Not to Degrade

Science Signaling, 2010
In vivo protein stoichiometries are regulated through N-terminally acetylated degrons.
openaire   +2 more sources

Targeted protein degradation and the enzymology of degraders

Current Opinion in Chemical Biology, 2018
Targeted protein degradation is an emerging strategy for drug discovery that employs small molecules to catalyze the ubiquitination of target proteins, ultimately causing their degradation by the proteasome. Current degrader designs employ hetero-bivalent molecules to recruit E3 ubiquitin ligases such as VHL, Cereblon, and the IAPs to the target ...
Stewart L, Fisher, Andrew J, Phillips
openaire   +2 more sources

Targeting EGFR degradation by autophagosome degraders

European Journal of Medicinal Chemistry
Several generations of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors have been developed for the treatment of non-small cell lung cancer (NSCLC) in clinic. However, emerging drug resistance mediated by new EGFR mutations or activations by pass, leads to malignant progression of NSCLC.
ZhongFeng, Zhu, Jiaying, Li, Shujun, Shen, Hawaa, Al-Furas, Shengrong, Li, Yichen, Tong, Yi, Li, Yucheng, Zeng, Qianyi, Feng, Kaiyue, Chen, Nan, Ma, Fengtao, Zhou, Zhang, Zhang, Zhengqiu, Li, Jiyan, Pang, Ke, Ding, Fang, Xu   +16 more
openaire   +2 more sources

Designed to degrade

Science, 2017
Suitably designed degradable polymers can play a role in reducing plastic ...
Ann-Christine, Albertsson, Minna, Hakkarainen   +1 more
openaire   +2 more sources