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Targeting EGFR degradation by autophagosome degraders
European Journal of Medicinal ChemistrySeveral generations of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors have been developed for the treatment of non-small cell lung cancer (NSCLC) in clinic. However, emerging drug resistance mediated by new EGFR mutations or activations by pass, leads to malignant progression of NSCLC.
ZhongFeng, Zhu +16 more
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Degradation Products in Degradable Polymers
Journal of Macromolecular Science, Part A, 1995Abstract Diffusion and migration of small molecules in polymers affect the long-term properties of the materials and also the surrounding environments. The interaction of such small molecules (i.e., low molecular weight compounds) with the environment are one of the main factors governing in-vitro and in-vivo behavior of degradable polymers.
Sigbritt Karlsson +1 more
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Journal of Pharmaceutical Sciences, 1989
Trimethoprim undergoes thermally and photochemically catalyzed hydrolysis or oxidation to give rise to at least five products. The structures of these compounds were determined by physical methods and it was found that the resonance of C-5 in the 13C NMR spectrum is indicative of the substitution pattern of the resultant amino hydroxy pyrimidines.
J J, Bergh +2 more
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Trimethoprim undergoes thermally and photochemically catalyzed hydrolysis or oxidation to give rise to at least five products. The structures of these compounds were determined by physical methods and it was found that the resonance of C-5 in the 13C NMR spectrum is indicative of the substitution pattern of the resultant amino hydroxy pyrimidines.
J J, Bergh +2 more
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Antioxidants & Redox Signaling, 2017
Glutathione degradation has for long been thought to occur only on noncytosolic pools. This is because there has been only one enzyme known to degrade glutathione (γ-glutamyl transpeptidase) and this localizes to either the plasma membrane (mammals, bacteria) or the vacuolar membrane (yeast, plants) and acts on extracellular or vacuolar pools. The last
Anand Kumar, Bachhawat, Amandeep, Kaur
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Glutathione degradation has for long been thought to occur only on noncytosolic pools. This is because there has been only one enzyme known to degrade glutathione (γ-glutamyl transpeptidase) and this localizes to either the plasma membrane (mammals, bacteria) or the vacuolar membrane (yeast, plants) and acts on extracellular or vacuolar pools. The last
Anand Kumar, Bachhawat, Amandeep, Kaur
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1983
This chapter describes the degradative plasmids. Microorganisms play a major role in the degradation of the products and by-products of the activities of animals and plants and other microorganisms. The failure of microorganisms to rapidly recycle any of these compounds results in their accumulation in the environment and can lead to the phenomenon of ...
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This chapter describes the degradative plasmids. Microorganisms play a major role in the degradation of the products and by-products of the activities of animals and plants and other microorganisms. The failure of microorganisms to rapidly recycle any of these compounds results in their accumulation in the environment and can lead to the phenomenon of ...
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2005
Hemoglobin degradation by Plasmodium is a massive catabolic process within the parasite food vacuole that is important for the organism's survival in its host erythrocyte. A proteolytic pathway is responsible for generating amino acids from hemoglobin.
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Hemoglobin degradation by Plasmodium is a massive catabolic process within the parasite food vacuole that is important for the organism's survival in its host erythrocyte. A proteolytic pathway is responsible for generating amino acids from hemoglobin.
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Archives of Biochemistry and Biophysics, 1953
Abstract Rate equations for a degrading system based on a simple step mechanism are considered. The initial attack is assumed to occur at random. It is followed by a further random depolymerization of the intermediate fragments but, in general, at a different rate.
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Abstract Rate equations for a degrading system based on a simple step mechanism are considered. The initial attack is assumed to occur at random. It is followed by a further random depolymerization of the intermediate fragments but, in general, at a different rate.
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The degradation of polymerase: biodegradation, microwave degradation and zeolite degradation
Eighth International Conference on Energy Materials and Electrical Engineering (ICEMEE 2022), 2023Xinyi Li, Xuliang Mao, kaiyu yang
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Fenamates are the most crucial non-steroidal anti-inflammatory drugs (NSAIDs) used to treat pain-related diseases. The clinically prescribed drugs of the fenamate group include mefenamic acid, tolfenamic acid, meclofenamic acid, flufenamic acid, and niflumic acid.
Sadia Hafeez, Kazi +3 more
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Sadia Hafeez, Kazi +3 more
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Annual Review of Sociology, 1987
Although social scientists have long believed that mechanization degrades skills, they disagree on the meaning and measurement of skills. A dominant view stresses that capitalists simplify skills to increase efficiency and profits; another, that managers deskill jobs to increase control over workers and work organization.
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Although social scientists have long believed that mechanization degrades skills, they disagree on the meaning and measurement of skills. A dominant view stresses that capitalists simplify skills to increase efficiency and profits; another, that managers deskill jobs to increase control over workers and work organization.
openaire +1 more source