Results 261 to 270 of about 2,374,007 (316)
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To Degrade or Not to Degrade DNMT3A
Cancer Discovery, 2022Abstract Summary: Aberrant DNA cytosine methylation is a critical contributor to compromised tissue regeneration and malignant transformation, particularly during aging. In this issue of Cancer Discovery, Huang and colleagues define a new class of disease-associated DNA (cytosine-5-)-methyltransferase
Yuhong, Ma, Britta, Will
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Protein folding and degradation in bacteria:¶To degrade or not to degrade? That is the question
Cellular and Molecular Life Sciences, 2002In Escherichia coli protein quality control is carried out by a protein network, comprising chaperones and proteases. Central to this network are two protein families, the AAA+ and the Hsp70 family. The major Hsp70 chaperone. DnaK, efficiently prevents protein aggregation and supports the refolding of damaged proteins. In a special case, DnaK, together
Dougan, David A. +2 more
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Annual Review of Plant Biology, 2005
Recent research reveals that starch degradation in Arabidopsis leaves at night is significantly different from the “textbook” version of this process. Although parts of the pathway are now understood, other parts remain to be discovered. Glucans derived from starch granules are hydrolyzed via β-amylase to maltose, which is exported from the ...
Smith, Alison M. +2 more
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Recent research reveals that starch degradation in Arabidopsis leaves at night is significantly different from the “textbook” version of this process. Although parts of the pathway are now understood, other parts remain to be discovered. Glucans derived from starch granules are hydrolyzed via β-amylase to maltose, which is exported from the ...
Smith, Alison M. +2 more
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Science Signaling, 2010
In vivo protein stoichiometries are regulated through N-terminally acetylated degrons.
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In vivo protein stoichiometries are regulated through N-terminally acetylated degrons.
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Targeted protein degradation and the enzymology of degraders
Current Opinion in Chemical Biology, 2018Targeted protein degradation is an emerging strategy for drug discovery that employs small molecules to catalyze the ubiquitination of target proteins, ultimately causing their degradation by the proteasome. Current degrader designs employ hetero-bivalent molecules to recruit E3 ubiquitin ligases such as VHL, Cereblon, and the IAPs to the target ...
Stewart L, Fisher, Andrew J, Phillips
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Science, 2017
Suitably designed degradable polymers can play a role in reducing plastic ...
Ann-Christine, Albertsson +1 more
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Suitably designed degradable polymers can play a role in reducing plastic ...
Ann-Christine, Albertsson +1 more
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Targeting EGFR degradation by autophagosome degraders
European Journal of Medicinal ChemistrySeveral generations of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors have been developed for the treatment of non-small cell lung cancer (NSCLC) in clinic. However, emerging drug resistance mediated by new EGFR mutations or activations by pass, leads to malignant progression of NSCLC.
ZhongFeng, Zhu +16 more
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Degradation Products in Degradable Polymers
Journal of Macromolecular Science, Part A, 1995Abstract Diffusion and migration of small molecules in polymers affect the long-term properties of the materials and also the surrounding environments. The interaction of such small molecules (i.e., low molecular weight compounds) with the environment are one of the main factors governing in-vitro and in-vivo behavior of degradable polymers.
Sigbritt Karlsson +1 more
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Journal of Pharmaceutical Sciences, 1989
Trimethoprim undergoes thermally and photochemically catalyzed hydrolysis or oxidation to give rise to at least five products. The structures of these compounds were determined by physical methods and it was found that the resonance of C-5 in the 13C NMR spectrum is indicative of the substitution pattern of the resultant amino hydroxy pyrimidines.
J J, Bergh +2 more
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Trimethoprim undergoes thermally and photochemically catalyzed hydrolysis or oxidation to give rise to at least five products. The structures of these compounds were determined by physical methods and it was found that the resonance of C-5 in the 13C NMR spectrum is indicative of the substitution pattern of the resultant amino hydroxy pyrimidines.
J J, Bergh +2 more
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Antioxidants & Redox Signaling, 2017
Glutathione degradation has for long been thought to occur only on noncytosolic pools. This is because there has been only one enzyme known to degrade glutathione (γ-glutamyl transpeptidase) and this localizes to either the plasma membrane (mammals, bacteria) or the vacuolar membrane (yeast, plants) and acts on extracellular or vacuolar pools. The last
Anand Kumar, Bachhawat, Amandeep, Kaur
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Glutathione degradation has for long been thought to occur only on noncytosolic pools. This is because there has been only one enzyme known to degrade glutathione (γ-glutamyl transpeptidase) and this localizes to either the plasma membrane (mammals, bacteria) or the vacuolar membrane (yeast, plants) and acts on extracellular or vacuolar pools. The last
Anand Kumar, Bachhawat, Amandeep, Kaur
openaire +2 more sources