Results 251 to 260 of about 2,986,953 (305)
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Targeted protein degradation and the enzymology of degraders
Current Opinion in Chemical Biology, 2018Targeted protein degradation is an emerging strategy for drug discovery that employs small molecules to catalyze the ubiquitination of target proteins, ultimately causing their degradation by the proteasome. Current degrader designs employ hetero-bivalent molecules to recruit E3 ubiquitin ligases such as VHL, Cereblon, and the IAPs to the target ...
Stewart L, Fisher, Andrew J, Phillips
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Targeting EGFR degradation by autophagosome degraders
European Journal of Medicinal ChemistrySeveral generations of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors have been developed for the treatment of non-small cell lung cancer (NSCLC) in clinic. However, emerging drug resistance mediated by new EGFR mutations or activations by pass, leads to malignant progression of NSCLC.
ZhongFeng, Zhu +16 more
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Science, 2017
Suitably designed degradable polymers can play a role in reducing plastic ...
Ann-Christine, Albertsson +1 more
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Suitably designed degradable polymers can play a role in reducing plastic ...
Ann-Christine, Albertsson +1 more
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The degrader gets degraded as cysteine fluctuates
Cell Chemical BiologyIn a recent issue of Molecular Cell, Ramage et al. identify a Cullin-RING E3 ubiquitin ligase complex defined by the substrate adaptor LRRC58 that inversely regulates the abundance of LRRC58 and its cognate substrate, CDO1, in response to cysteine levels.1.
Junyi, Chen, Haopeng, Xiao
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Degradation Products in Degradable Polymers
Journal of Macromolecular Science, Part A, 1995Abstract Diffusion and migration of small molecules in polymers affect the long-term properties of the materials and also the surrounding environments. The interaction of such small molecules (i.e., low molecular weight compounds) with the environment are one of the main factors governing in-vitro and in-vivo behavior of degradable polymers.
Sigbritt Karlsson +1 more
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Journal of Pharmaceutical Sciences, 1989
Trimethoprim undergoes thermally and photochemically catalyzed hydrolysis or oxidation to give rise to at least five products. The structures of these compounds were determined by physical methods and it was found that the resonance of C-5 in the 13C NMR spectrum is indicative of the substitution pattern of the resultant amino hydroxy pyrimidines.
J J, Bergh +2 more
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Trimethoprim undergoes thermally and photochemically catalyzed hydrolysis or oxidation to give rise to at least five products. The structures of these compounds were determined by physical methods and it was found that the resonance of C-5 in the 13C NMR spectrum is indicative of the substitution pattern of the resultant amino hydroxy pyrimidines.
J J, Bergh +2 more
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Antioxidants & Redox Signaling, 2017
Glutathione degradation has for long been thought to occur only on noncytosolic pools. This is because there has been only one enzyme known to degrade glutathione (γ-glutamyl transpeptidase) and this localizes to either the plasma membrane (mammals, bacteria) or the vacuolar membrane (yeast, plants) and acts on extracellular or vacuolar pools. The last
Anand Kumar, Bachhawat, Amandeep, Kaur
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Glutathione degradation has for long been thought to occur only on noncytosolic pools. This is because there has been only one enzyme known to degrade glutathione (γ-glutamyl transpeptidase) and this localizes to either the plasma membrane (mammals, bacteria) or the vacuolar membrane (yeast, plants) and acts on extracellular or vacuolar pools. The last
Anand Kumar, Bachhawat, Amandeep, Kaur
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2012
After roughly 100 years of controlled clinical use, the in vivo and in vitro degradation mechanisms of ceramic materials are still largely unknown. In bioinert ceramics such as alumina and zirconia used in orthopedics, crack propagation mechanisms are well known, but their interactions with other degradation mechanisms (low-temperature degradation ...
Gremillard, Laurent +7 more
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After roughly 100 years of controlled clinical use, the in vivo and in vitro degradation mechanisms of ceramic materials are still largely unknown. In bioinert ceramics such as alumina and zirconia used in orthopedics, crack propagation mechanisms are well known, but their interactions with other degradation mechanisms (low-temperature degradation ...
Gremillard, Laurent +7 more
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1983
This chapter describes the degradative plasmids. Microorganisms play a major role in the degradation of the products and by-products of the activities of animals and plants and other microorganisms. The failure of microorganisms to rapidly recycle any of these compounds results in their accumulation in the environment and can lead to the phenomenon of ...
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This chapter describes the degradative plasmids. Microorganisms play a major role in the degradation of the products and by-products of the activities of animals and plants and other microorganisms. The failure of microorganisms to rapidly recycle any of these compounds results in their accumulation in the environment and can lead to the phenomenon of ...
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2005
Hemoglobin degradation by Plasmodium is a massive catabolic process within the parasite food vacuole that is important for the organism's survival in its host erythrocyte. A proteolytic pathway is responsible for generating amino acids from hemoglobin.
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Hemoglobin degradation by Plasmodium is a massive catabolic process within the parasite food vacuole that is important for the organism's survival in its host erythrocyte. A proteolytic pathway is responsible for generating amino acids from hemoglobin.
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