Results 111 to 120 of about 7,051,446 (291)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
PLoS ONEDibutyl phthalate (DBP) with teratogenicity, carcinogenesis, and mutagenesis, is a ubiquitous endocrine disruptor in the environment. The widespread usage of plastic mulch has resulted in a severe DBP pollution problem in agricultural soil.
Yong Li, Sidan Gong, Huan Liu, Yajie Li
doaj +1 more source
Metabolic Engineering CommunicationsPlastic waste has caused a global environmental crisis. Biocatalytic depolymerization mediated by enzymes has emerged as an efficient and sustainable alternative for plastic treatment and recycling.
Renjing Jiang +4 more
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Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Rank, Degrading Treatment, and the Italy‐Albania Agreement
In November 2023, Italy signed a five‐year agreement with Albania to transfer asylum seekers intercepted in international waters by Italian vessels to Italian‐run detention centres in Albania for asylum processing and deportation.
Obed Adonteng‐Kissi, Jamal Barnes
core +1 more source
Review and prospect of aniline-degrading bacteria for treating aniline wastewater
Gongye shui chuliAniline wastewater exhibits high toxicity and recalcitrance, posing substantial challenges to industrial wastewater treatment. Although biological treatment methods are environmentally friendly and cost-effective, their practical application is hindered ...
ZHANG Wenmei +7 more
doaj +1 more source
Degradation of LRRK2 in the Treatment of Parkinson’s Disease [PDF]
ACS Medicinal Chemistry Letters, 2020 openaire +2 more sources
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source