Results 121 to 130 of about 7,051,446 (291)

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

PROTAC Degradation of IRAK4 for the Treatment of Cancer [PDF]

ACS Medicinal Chemistry Letters, 2019
openaire   +2 more sources

Discovery of PRMT3 Degrader for the Treatment of Acute Leukemia

Advanced Science
AbstractProtein arginine methyltransferase 3 (PRMT3) plays an important role in gene regulation and a variety of cellular functions, thus, being a long sought‐after therapeutic target for human cancers. Although a few PRMT3 inhibitors are developed to prevent the catalytic activity of PRMT3, there is little success in removing the cellular levels of ...
Wanyi Zou, Mengna Li, Shili Wan, Jingkun Ma, Linan Lian, Guanghao Luo, Yubo Zhou, Jia Li, Bing Zhou   +8 more
openaire   +3 more sources

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Ecological Dynamics of Toxic Microcystis spp. and Microcystin-Degrading Bacteria in Dianchi Lake, China

, 2014
Toxic cyanobacterial blooms directly threaten both human safety and the ecosystem of surface waters. The widespread occurrence of these organisms, coupled with the tumor-promoting properties of the microcystin toxins that they produce, demands action to ...
Zhu, Lin, Wu, Yanlong, Gan, NQ (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Peoples R China., Gan, Nanqin, Song, Lirong   +4 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Gender violence and degrading treatment. Between invisibility and denial

Feminismo/s, 2005
Miguel Lorente Acosta
doaj   +1 more source

Degradation of BiTeCl induced by thermal and laser treatment

Scientific Reports
Abstract This study examines the thermal stability and structural behavior of bismuth chloride telluride BiTeCl, a layered thermoelectric material with significant potential for energy conversion applications. Our investigations reveal that the chlorine-terminated surface exhibits poorer quality and increased defectivity compared to the ...
Ryś, Wojciech, Lutsyk, Iaroslav, Szałowski, Karol, Ster, Maxime Le, Rogala, Maciej, Piskorski, Michał, Krukowski, Paweł, Dąbrowski, Paweł, Dunal, Rafał, Nadolska, Aleksandra, Przybysz, Przemysław, Toczek, Klaudia, Kozłowski, Witold, Kowalczyk, Paweł J.   +13 more
openaire   +3 more sources

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source